Keratin 8 Proteins (KRT8)

KRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Additionally we are shipping Keratin 8 Antibodies (793) and Keratin 8 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KRT8 3856 P05787
KRT8 16691 P11679
KRT8 25626 Q10758
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Top Keratin 8 Proteins at

Showing 10 out of 39 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Yeast Golden Syrian Hamster His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human GST tag Keratin 8 (KRT8) (AA 2-483), (full length) protein (GST tag) 50 μg Log in to see 13 to 16 Days
Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 11 Days
Cow Cow Un-conjugated   100 μg Log in to see 6 to 8 Days
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 6 to 8 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human Un-conjugated   5 μg Log in to see 2 to 3 Days

KRT8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Keratin 8 (KRT8) Interaction Partners

Human Keratin 8 (KRT8) interaction partners

  1. regulated enhancement of autophagy with concurrent increased expression of KRT8 and the inhibition of KRT8 phosphorylation serve to inhibit oxidative stress-induced (show SQSTM1 Proteins) epithelial-mesenchymal transitionof retinal pigment epithelium cells.

  2. Histopathological differences between Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU)-ablated tissue and radiofrequency (RF)-ablated tissue were demonstrated. CK-8 was more reliable for cell viability assessment than H&E when used directly after ablation

  3. Loss of activating transcription factor 3 (ATF3 (show ATF3 Proteins)) in knockout mice promotes the emergence of keratins CK5 (show KRT5 Proteins)+CK8+ epithelial cells.

  4. Data show that the filament elongation of both desmin (show DES Proteins) and keratin K8/K18 (show KRT18 Proteins) proceeds very similar to that of vimentin (show VIM Proteins).

  5. New insights into interactions between the nucleotide-binding domain of CFTR (show CFTR Proteins) and keratin 8.

  6. We present results of a multicentre study measuring UBC (show RPS27A Proteins)((R)) Rapid Test(test that detects fragments of cytokeratins 8 and 18 in urine) in bladder cancer patients and healthy controls with focus on carcinoma in situ (CIS (show CISH Proteins)) and high-grade bladder cancer.

  7. Data show that after siRNA transfection, TGF-beta1 (show TGFB1 Proteins) protein level was decreased, and CK18 (show KRT18 Proteins) proteins was decreased, while CK8 proteins was increased, and TERT (show TERT Proteins) protein expression was slightly increased at 96 h.

  8. The interplay between Solo protein and keratin 8/keratin 18 filaments plays a crucial role in tensile force-induced RhoA activation and consequent actin cytoskeletal reinforcement in endothelial cells.

  9. K8/18 filaments provide resistance to apoptosis in granulosa cell tumor cells by impairing FAS (show FAS Proteins) expression.

  10. These metastatic tumors revealed no detectable expression of CK8/18, E-cadherin (show CDH1 Proteins), VCAM-1 (show VCAM1 Proteins), and ICAM-1 (show ICAM1 Proteins)

Pig (Porcine) Keratin 8 (KRT8) interaction partners

  1. This study reveals clear genetic-statistical evidence for a link of KRT8, FAF1 (show FAF1 Proteins) and PTH1R (show PTH1R Proteins) with some of leg weakness related traits in pigs.

  2. Mechanical injury of vascular smooth muscle up-regulated keratin 8.

Cow (Bovine) Keratin 8 (KRT8) interaction partners

  1. Results did not support that K8/K18 (show KRT18 Proteins) filaments influence the expression of Fas (show FAS Proteins) on the surface of luteal cells.

Mouse (Murine) Keratin 8 (KRT8) interaction partners

  1. Mitochondria in K8 wild-type beta cells and MIN6 insulinoma cells overexpressing K8 and 18 are more stationary compared with mitochondria in keratin-deficient cells

  2. K8/K18 (show KRT18 Proteins)-dependent PKCdelta (show PKCd Proteins)- and ASMase (show SMPD1 Proteins)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Proteins) loss.

  3. DRA mRNA levels were decreased by three- to fourfold and DRA protein was almost entirely lost in K8-/- cecum and proximal and distal colon compared with K8+/+.

  4. Upregulation of IL-22 (show IL22 Proteins) in combination with a complete loss of its negative regulator IL-22BP (show IL22RA2 Proteins), and increased downstream STAT3 (show STAT3 Proteins)-signaling in K8(-/-) and K8(-/-)Apc (show APC Proteins)(Min/+) colonic epithelia confirmed that the IL-22 (show IL22 Proteins) pathway, important in inflammation, proliferation and tissue regeneration

  5. Krt8 deletion (Krt8(-/-)) in a mouse model of cystic fibrosis (show S100A8 Proteins) (F508del-Cftr (show CFTR Proteins) mice) increased the levels of circulating markers of bone formation, corrected the expression of osteoblast phenotypic genes, promoted trabecular bone formation and improved bone mass and microarchitecture. Krt8 deletion corrected overactive NF-kappaB (show NFKB1 Proteins) signaling & decreased Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling induced by F508del-Cftr (show CFTR Proteins) mutation in osteoblasts.

  6. Autoantibodies to several antigens were identified in 81% of K8-null male mice 8 mo or older. Similar autoantibodies were detected in aging K18 (show KRT18 Proteins)-null male mice that had a related liver phenotype but normal colon compared with K8-null mice

  7. The regulation of the SCFA-MCT1 (show MCTS1 Proteins)-HMGCS2 (show HMGCS2 Proteins) axis is disrupted in K8(-/-) colonocytes, suggesting a role for keratins in colonocyte energy metabolism and homeostasis.

  8. In several liver stress models epiplakin and K8 genes displayed identical expression patterns and transgenic K8 overexpression resulted in elevated hepatic epiplakin levels.

  9. In human failing myocardium, where TNF-alpha (show TNF Proteins) expression is upregulated, K8/K18 (show KRT18 Proteins) were also ectopically expressed

  10. The findings demonstrate the near complete loss of K8/K18 (show KRT18 Proteins) with concomitant high levels of vimentin (show VIM Proteins) in CT26 (show DDX53 Proteins) cells, a chemically-induced mouse colonic tumor.

Zebrafish Keratin 8 (KRT8) interaction partners

  1. Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18.

Keratin 8 (KRT8) Protein Profile

Protein Summary

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with Keratin 8 Proteins (KRT8)

  • keratin 8 (krt8)
  • keratin, type II cytoskeletal 8 pseudogene (LOC693415)
  • keratin, type II cytoskeletal 8 (LOC697116)
  • keratin 8 (KRT8)
  • keratin 8 pseudogene (LOC743020)
  • keratin 8 pseudogene (LOC100345306)
  • keratin 8 (Krt8)
  • keratin 8 S homeolog (krt8.S)
  • AA960620 protein
  • AL022697 protein
  • AU019895 protein
  • Card2 protein
  • cb186 protein
  • CK-8 protein
  • CK8 protein
  • CYK8 protein
  • CYKER protein
  • DKFZp468F2127 protein
  • DreK8 protein
  • EndoA protein
  • K2C8 protein
  • K8 protein
  • KERATIN8 protein
  • KO protein
  • Krt-2.8 protein
  • krt2-5 protein
  • krt2-8 protein
  • KRT8 protein
  • MGC69490 protein
  • sb:cb186 protein
  • wu:fa20h05 protein
  • wu:fa95h10 protein
  • wu:fb96c06 protein
  • zf-K8 protein
  • zfk8 protein

Protein level used designations for Keratin 8 Proteins (KRT8)

keratin 8 , keratin complex 2, basic, gene 5 , cytokeratin 8 , cytokeratin-8 , keratin, type II cytoskeletal 8 , type-II keratin Kb8 , CK-8 , K8 , KERA , cytokeratin-A , keratin-8 , cytokeratin endo A , keratin complex 2, basic, gene 8 , etID33550.23 , etID43142.23 , etID43142.8 , keratin, type 2, gene 8

431676 Xenopus (Silurana) tropicalis
693415 Macaca mulatta
697116 Macaca mulatta
700449 Macaca mulatta
737628 Pan troglodytes
743020 Pan troglodytes
100174430 Pongo abelii
100345306 Oryctolagus cuniculus
3856 Homo sapiens
100152077 Sus scrofa
281269 Bos taurus
101110495 Ovis aries
100348891 Oryctolagus cuniculus
16691 Mus musculus
25626 Rattus norvegicus
797433 Danio rerio
380217 Xenopus laevis
426896 Gallus gallus
486513 Canis lupus familiaris
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