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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.
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Human Monoclonal KIR2DS4 Primary Antibody for FACS - ABIN4898690
Béziat, Dalgard, Asselah, Halfon, Bedossa, Boudifa, Hervier, Theodorou, Martinot, Debré, Björkström, Malmberg, Marcellin, Vieillard: CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients. in European journal of immunology 2012
Show all 3 Pubmed References
Human Polyclonal KIR2DS4 Primary Antibody for IF (p), IHC (p) - ABIN748478
Mozer-Lisewska, Mania, Kowala-Piaskowska, Kluk, Samara, Pauli, ?eromski: Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers. in Archivum immunologiae et therapiae experimentalis 2014
KIR2DS4 was associated with significant reduced incidence of relapse of hematological malignancies after hematopoietic stem cell transplantation from matched sibling
KIR (show GEM Antibodies) 2D (L1, L3, L4, S4) and KIR 3DL1 (show KIR3DL1 Antibodies) expression was correlated with poor prognosis in non-small cell lung carcinoma patients.
KIR2DS4, KIR2DS1, and some alleles of KIR2DS5 contribute to successful pregnancy suggests that activation of uNK cells by KIR binding to HLA-C is a generic mechanism promoting trophoblast invasion into the decidua.
Our findings suggest that KIR2DS4*00101 may offer a molecular biomarker to identify intrinsically milder forms of glioblastoma
Data indicate the allelic diversity of KIR2DS4 proteni among ethnic Hans from southern China, which may provide data for transplantation as well as studies on KIR (show GEM Antibodies)-associated disease and evolution.
this study shows that the expression of full-length KIR2DS4 allele variants may contribute to a worse clinical outcome after hematopoietic stem cell transplantation
Type 1 pediatric autoimmune hepatitis patients show increased frequency of KIR2DS4-Full Length, which in combination with HLA-DRB1 (show HLA-DRB1 Antibodies)*1301 revealed a strong synergistic effect. Adult autoimmune hepatitis cases have shown a weaker increased frequency of KIR2DS4-FL, a lack of synergistic effect with HLA class II antigens.
Collectively, our data suggest that the KIR 2DS4/1D allelic variance is associated with the outcome of sibling-related HLA-matched HSCT, and that donor subclassification of KIR 2DS4/1D alleles should be considered in this setting.
genetic association study in population in Eastern India: Data suggest that interactions between KIRs (KIR2DL2 (show KIR2DL2 Antibodies), KIR2DS4, KIR2DL3 (show KIR2DL3 Antibodies)) and HLA ligands (HLAC1, HLAC2) contribute significantly toward susceptibility and protection toward type 1 diabetes.
KIR2DS4 can induce the uptake of CCR7 (show CCR7 Antibodies) by KIR2DS4(+) NKG2A (show KLRC1 Antibodies)(+) natural killer cell clones after interacting with CCR7 (show CCR7 Antibodies)(+) target cells expressing HLA-Cw4 and HLA-Cw6 alleles.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\; thus, KIR proteins are thought to play an important role in regulation of the immune response.
CD158 antigen-like family member I
, KIR antigen 2DS4
, MHC class I NK cell receptor
, P58 natural killer cell receptor clones CL-39/CL-17
, killer cell immunoglobulin-like receptor 2DS4
, killer inhibitory receptor 4-1-2
, natural killer cell inhibitory receptor
, natural killer-associated transcript 8
, p58 NK receptor CL-39/CL-17