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Location-regulated scaffolding protein connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 1 Antibodies (109) and Kinase Suppressor of Ras 1 Proteins (9) and many more products for this protein.
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the atypical C1 domain, the CC-SAM (show TTN ELISA Kits) domain is required to target KSR-1 to the plasma membrane.
KSR is a scaffold required for activation of the ERK/MAPK (show MAPK1 ELISA Kits) module.
Review discusses the possibility that KSR, a RAF (show ARAF ELISA Kits)-like protein, does not solely act as a scaffold, but directly induces RAF (show RAF1 ELISA Kits) catalytic function by a kinase-independent mechanism apparently shared by RAF (show RAF1 ELISA Kits)-like proteins.
DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF (show RAF1 ELISA Kits).
praja2 regulates KSR1 stability and mitogenic signaling.
These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding.
Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.
propose that phosphorylation of Tyr (show TYR ELISA Kits)(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses
Data indicate that phosphorylation of BRAF (show BRAF ELISA Kits) by AMPK (show PRKAA1 ELISA Kits) disrupts its association with KSR1.
Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR (show FRAP1 ELISA Kits)-dependent T cell differentiation.
Ksr1 plays a dispensable role in lipopolysaccharide (LPS)-induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model.
The loss of Ksr1 inhibits Ras/Mapk (show MAPK1 ELISA Kits) pathway signaling leading to increased Myc (show MYC ELISA Kits)-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.
findings demonstrate that KSR-MEK (show MAP2K1 ELISA Kits) complexes allosterically activate BRAF (show BRAF ELISA Kits) through the action of N-terminal regulatory region and kinase domain contacts and challenge the accepted role of KSR as a scaffold for MEK (show MAP2K1 ELISA Kits) recruitment to RAF (show RAF1 ELISA Kits)
Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer
Data show that neurofibromin 2 (Merlin (show NF2 ELISA Kits)) suppresses proliferation and adhesion, at least partly, through inhibiting kinase suppressor of Ras 1 (KSR1) and DCAF1 protein.
Upregulation of KSR1 is associated with Colorectal cancer.
the relative mRNA copy values of KSR1, ERK1 (show MAPK3 ELISA Kits) and ERK2 (show MAPK1 ELISA Kits) in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 (show MAPK1/3 ELISA Kits) pathway in gastric cancer
KSR1 rs2241906 variants may predict survival in patients with advanced ERalpha (show ESR1 ELISA Kits)+ BC treated with adjuvant TAM (show CCNA1 ELISA Kits).
KSR1 is coordinately regulated with Notch (show NOTCH1 ELISA Kits) signaling and oxidative phosphorylation in papillary thyroid cancer.
KSR1 stabilizes BRCA1 by reducing BRCA1 ubiquitination, inhibits tumor growth through BRCA1, and regulates BRCA1 stability via elevated BARD1 (show BARD1 ELISA Kits) abundance and increased BRCA1-BARD1 (show BARD1 ELISA Kits) interaction
Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
, kinase suppressor of Ras85D
, suppressor of Ras1 3-1
, kinase suppressor of Ras 1
, protein Hb