Kinase Suppressor of Ras 1 (KSR1) ELISA Kits

Location-regulated scaffolding protein connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 1 Antibodies (120) and Kinase Suppressor of Ras 1 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
KSR1 16706 Q61097
Anti-Rat KSR1 KSR1 360573  
KSR1 8844 Q8IVT5
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Kinase Suppressor of Ras 1 ELISA Kits at antibodies-online.com

Showing 3 out of 10 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse
  96 Tests Log in to see 2 to 3 Days
$867.90
Details
Human
  96 Tests Log in to see 2 to 3 Days
$480.00
Details
Human
  96 Tests Log in to see 11 to 18 Days
$653.82
Details

More ELISA Kits for Kinase Suppressor of Ras 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Kinase Suppressor of Ras 1 (KSR1) interaction partners

  1. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane.

  2. KSR is a scaffold required for activation of the ERK/MAPK module.

  3. Review discusses the possibility that KSR, a RAF-like protein, does not solely act as a scaffold, but directly induces RAF catalytic function by a kinase-independent mechanism apparently shared by RAF-like proteins.

Mouse (Murine) Kinase Suppressor of Ras 1 (KSR1) interaction partners

  1. DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF.

  2. praja2 regulates KSR1 stability and mitogenic signaling.

  3. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding.

  4. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.

  5. propose that phosphorylation of Tyr(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses

  6. Data indicate that phosphorylation of BRAF by AMPK disrupts its association with KSR1.

  7. Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation.

  8. Ksr1 plays a dispensable role in lipopolysaccharide (LPS)-induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model.

  9. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane.

  10. The loss of Ksr1 inhibits Ras/Mapk pathway signaling leading to increased Myc-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.

  11. a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1

  12. Genetic disruption of KSR1 results in striking reductions in kit-ligand-mediated proliferation & degranulation and impacts the biochemical activation of p21-activated kinase.

  13. Data suggest that feedback phosphorylation of KSR1 prevents excessive ERK1/2 signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability.

  14. findings suggest that Ksr1 functions as a previously unknown scaffold that enhances iNOS activity and is therefore crucial for the pulmonary response to P. aeruginosa infections

  15. KSR1 is a functional protein kinase, MEK1 is an in vitro substrate of KSR1, and the catalytic activities of both proteins are required for eliciting cell survival responses downstream of TNF.

  16. Mice lacking both KSR1 and IL-10 develop exacerbated colitis due to dysregulated IFN-gamma production in T lymphocytes.

  17. despite a requirement for KSR1 for full ERK activation in thymocytes, full and efficient ERK activation is not essential for the majority of thymocyte selection events.

  18. Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor.

  19. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

  20. evidence for interaction of Nm23-H1 and the suppressor of kinase Ras(KSR)in mammalian cells; can phosphorylate KSR via a histidine-dependent pathway

Human Kinase Suppressor of Ras 1 (KSR1) interaction partners

  1. findings demonstrate that KSR-MEK complexes allosterically activate BRAF through the action of N-terminal regulatory region and kinase domain contacts and challenge the accepted role of KSR as a scaffold for MEK recruitment to RAF

  2. Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer

  3. praja2 regulates KSR1 stability and mitogenic signaling.

  4. Data show that neurofibromin 2 (Merlin) suppresses proliferation and adhesion, at least partly, through inhibiting kinase suppressor of Ras 1 (KSR1) and DCAF1 protein.

  5. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding.

  6. Upregulation of KSR1 is associated with Colorectal cancer.

  7. the relative mRNA copy values of KSR1, ERK1 and ERK2 in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer

  8. KSR1 rs2241906 variants may predict survival in patients with advanced ERalpha+ BC treated with adjuvant TAM.

  9. KSR1 is coordinately regulated with Notch signaling and oxidative phosphorylation in papillary thyroid cancer.

  10. KSR1 stabilizes BRCA1 by reducing BRCA1 ubiquitination, inhibits tumor growth through BRCA1, and regulates BRCA1 stability via elevated BARD1 abundance and increased BRCA1-BARD1 interaction

  11. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.

  12. Data indicate that phosphorylation of BRAF by AMPK disrupts its association with KSR1.

  13. Our findings integrate KSR1 into a network involving DBC1 and SIRT1, which results in the regulation of p53 acetylation and its transcriptional activity.

  14. Elevated levels of phosphorylated KSR were detected in the nuclear fractions.

  15. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane.

  16. VRK2A can form a high molecular size complex with both MEK1 and KSR1; the KSR1 complex assembled and retained by VRK2A in the endoplasmic reticulum can have a modulatory effect on the signal mediated by MAPK,locally affecting the magnitude of its responses

  17. simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1

  18. Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.

  19. KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels

  20. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells.

Kinase Suppressor of Ras 1 (KSR1) Antigen Profile

Antigen Summary

Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

Gene names and symbols associated with KSR1

  • kinase suppressor of ras 1 (KSR1) antibody
  • kinase suppressor of ras (ksr) antibody
  • kinase suppressor of ras 1 (Ksr1) antibody
  • AW492498 antibody
  • B-KSR1 antibody
  • CG2899 antibody
  • D11Bhm183e antibody
  • D11Bhm184e antibody
  • dKsr antibody
  • Dmel\\CG2899 antibody
  • EK3-1 antibody
  • hb antibody
  • Ksr antibody
  • Ksr-1 antibody
  • l(3)j5E2 antibody
  • RSU2 antibody
  • SR3-1 antibody

Protein level used designations for KSR1

CG2899-PA , kinase suppressor of Ras85D , ksr-PA , suppressor of Ras1 3-1 , kinase suppressor of Ras 1 , mKSR1 , protein Hb

GENE ID SPECIES
100071912 Equus caballus
40660 Drosophila melanogaster
16706 Mus musculus
360573 Rattus norvegicus
8844 Homo sapiens
427839 Gallus gallus
610451 Canis lupus familiaris
100511282 Sus scrofa
100138565 Bos taurus
Selected quality suppliers for Kinase Suppressor of Ras 1 (KSR1) ELISA Kits
Did you look for something else?