anti-Kinesin Family Member 4A (KIF4A) Antibodies

Human Kinesin Family Member 4A (KIF4A) interaction partners

1. these findings not only demonstrate that KIF4A contributes to colorectal carcinoma proliferation via modulation of p21-mediated cell cycle progression but also suggest the potential value of KIF4A as a clinical prognostic marker and target for molecular treatments.

2. Phosphorylated Kif4A (Kif4AWT) or Cdk phospho-mimetic Kif4A mutant (Kif4ATE) associated with chromosomes and condensin I (non-SMC subunit CAP-G and core subunit SMC2) to regulate chromosome condensation, spindle morphology, and chromosome congression/alignment in early mitosis.

3. AMPK and Aurora B competitively phosphoregulate KIF4A during mitotic phase due to overlapping recognition motifs, resulting in the elaborate phosphoregulation for KIF4A-dependent central spindle length control.

4. We found that KIF4A was dominantly regulated by FOXM1c among the four isoforms, and further identified KIF4A as a direct downstream target of FOXM1c. Inhibiting FOXM1 decreased KIF4A expression in hepatocellular carcinoma (HCC) cells, whereas its overexpression had the opposite effect.

5. KIF4A may act as a prognostic biomarker and potential therapeutic target in human Hepatocellular carcinoma.

6. The results revealed that circKIF4A and KIF4A could bind to miR-375 and that circKIF4A regulated the expression of KIF4A via sponging miR-375.

7. our novel results revealed that Cdk1-dependent KIF4A phosphorylation at S1186 is a trigger for chromosomal organization during early mitosis.

8. Here, the authors show that the collective activity of PRC1 and Kif4A results in relative microtubule sliding and concurrent end-tag formation on antiparallel microtubules.

9. This work identified KIF4A as a potential predictive and prognostic marker for hepatocellular carcinoma.

10. KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane

11. High KIF4A expression is associated with lung cancer.

12. decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms.

13. Neither KIF4A nor condensin I alone can sufficiently accumulate on the chromosomal axis and confer physiological properties to chromosomes, thus establishing that the functions of KIF4A and condensin I are inseparable

14. Chromokinesin represents a kinesin superfamily regulating cell division through chromosome and spindle. (Review)

15. Hepatitis B virus activates the KIF4A gene promoter and upregulates the mRNA and protein expression of KIF4A.

16. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase.

17. KIF4A might be a key regulator for tumoral progression in OSCCs.

18. Genetic association of KIF4A and KIF5C mutations in intellectual disability and synaptic function.

19. The KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1.

20. Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length.