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KIF4A encodes a member of the kinesin 4 subfamily of kinesin related proteins.
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Human Polyclonal KIF4A Primary Antibody for ICC, IF - ABIN249557
Sekine, Okada, Noda, Kondo, Aizawa, Takemura, Hirokawa: A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally. in The Journal of cell biology 1994
Human Polyclonal KIF4A Primary Antibody for IP, WB - ABIN5665648
Shrestha, Wilmeth, Eyer, Shuster: PRC1 controls spindle polarization and recruitment of cytokinetic factors during monopolar cytokinesis. in Molecular biology of the cell 2012
High KIF4A expression is associated with lung cancer.
decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms.
Neither KIF4A nor condensin I alone can sufficiently accumulate on the chromosomal axis and confer physiological properties to chromosomes, thus establishing that the functions of KIF4A and condensin I are inseparable
Chromokinesin represents a kinesin superfamily regulating cell division through chromosome and spindle. (Review)
Hepatitis B virus activates the KIF4A gene promoter and upregulates the mRNA and protein expression of KIF4A.
KIF4A and PP2A (show PPP2R4 Antibodies)-B56G (show PPP2CA Antibodies) and -B56E create a spatially restricted negative feedback loop counteracting Aurora B (show AURKB Antibodies) in anaphase.
KIF4A might be a key regulator for tumoral progression in OSCCs.
Genetic association of KIF4A and KIF5C (show KIF5C Antibodies) mutations in intellectual disability and synaptic function.
The KIF4A phosphorylation by Aurora B (show AURKB Antibodies) stimulates the maximal microtubule-dependent ATPase (show DNAH8 Antibodies) activity of KIF4A and promotes its interaction with PRC1 (show PRC1 Antibodies).
Studies reveal how interactions between the conserved nonmotor MAP, PRC1 (show PRC1 Antibodies), and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 (show PRC1 Antibodies) tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length.
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.
kinesin family member 4A
, chromosome-associated kinesin KIF4A-like
, chromosome-associated kinesin KIF4A
, kinesin family member 4
, kinesin heavy chain member 4
, chromosome-associated kinesin KIF4