anti-Kruppel-Like Factor 1 (erythroid) (KLF1) Antibodies

KLF1 encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. Additionally we are shipping KLF1 Proteins (6) and KLF1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KLF1 10661 Q13351
KLF1 16596  
KLF1 304666  
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Top anti-KLF1 Antibodies at antibodies-online.com

Showing 10 out of 82 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KLF1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KLF1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ChIP, ELISA, IHC   100 μg Log in to see 6 to 7 Days
$429.62
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KLF1 Antibody Titration:  2.5ug/ml  Positive Control:  K562 cell lysate KLF1 is supported by BioGPS gene expression data to be expressed in K562 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Mouse Un-conjugated ELISA, FACS, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using KLF1 mAb against human KLF1 recombinant protein. (Expected MW is 42.6 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$561.00
Details
Human Rabbit Un-conjugated WB KLF1 Antibody (C-term) (ABIN658420) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the KLF1 antibody detected the KLF1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB WB Image Sample (100ug of whole cell lysate) A: 293T (mock) B: 293T transfected KLF1 antibody diluted at 1:2000 100 μL Log in to see 3 to 4 Days
$380.38
Details
Human Mouse Un-conjugated CyTOF, ELISA, FACS, IHC, WB Immunohistochemistry: KLF1 Antibody (1B6A3) [NBP2-37380] - Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using KLF1 mouse mAb with DAB staining. ELISA: KLF1 Antibody (1B6A3) [NBP2-37380] - Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng); 0.1 mL Log in to see 7 to 9 Days
$514.63
Details

Top referenced anti-KLF1 Antibodies

  1. Mouse (Murine) Monoclonal KLF1 Primary Antibody for ChIP, IP - ABIN2668639 : Sengupta, Cohet, Morlé, Bieker: Distinct modes of gene regulation by a cell-specific transcriptional activator. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal KLF1 Primary Antibody for FACS, IHC - ABIN1724828 : Zhou, Liu, Sun, Pawlik, Townes: KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. in Nature genetics 2010 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal KLF1 Primary Antibody for ELISA, WB - ABIN524111 : Akgül, Lin, Ou Yang, Chen, Lu, Chen, Kikuchi, Chen, Tu: Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. in PLoS ONE 2011 (PubMed)

  4. Human Polyclonal KLF1 Primary Antibody for ChIP, ELISA - ABIN249501 : Pandya, Townes: Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1. in The Journal of biological chemistry 2002 (PubMed)

  5. Human Polyclonal KLF1 Primary Antibody for WB - ABIN4228488 : Wong, Hou, Tseng, Chien, Wu, Chen, Ho, Kyo, Teng: Krüppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells. in Stem cells (Dayton, Ohio) 2010 (PubMed)

More Antibodies against KLF1 Interaction Partners

Human Kruppel-Like Factor 1 (erythroid) (KLF1) interaction partners

  1. 3 new mutations were found KLF1*90A (p.Trp30Ter), KLF*911A (p.Thr304Lys), and KLF1*304C,318G (p. Ser102Pro, Tyr106Ter) in 2 unrelated individuals. 2 others had c.954dupG (p.Arg319Glufs*34), that is, KLF1*BGM06. A child with unexplained anemia had c.973G>A (p.Glu325Lys), associated with congenital dyserythropoietic anemia. The common c.304T>C was found in 2 of 7 samples and 60 of 100 blood donors.

  2. 4 individuals who were Lua and Lub negative were identified from 5420 unrelated blood donors. KLF1 allele with c.199delA and c.304T>C in Exon 2 was identified in one individual, which caused a frameshift at AA67 and formed a new premature stop codon at nucleotide position 708 p.(Gly68AlafsTer236). One KLF1 allele with c.304T>C and c.604G>A was found in another, which resulted which resulted in p.Ser102Pro and p.Gly202A.

  3. Changes in HbA2 (show HBa2 Antibodies) and HbF in alpha thalassemia carriers with KLF1 mutation.

  4. Reduction of KLF1 expression in beta(0)-thalassemia/HbE (show HBe1 Antibodies) erythroblasts can increase HbF levels.

  5. Alterations in high HbF levels may be associated with KLF1 gene mutations.

  6. KLF1 enhancer sequence is frequently hypermethylated in juvenile myelomonocytic leukemia.

  7. Findings suggest that the induction of an indel mutation in the Kruppel like factor 1 (KLF1) gene leading to a null allele.

  8. KLF1 is an important genetic factor associated with increased Hb F and in combination with other modifying factors could explain the phenotypic variation of Hb F expression in this common hemoglobinopathy.

  9. Activation of KLF1 at day 10 of the differentiation process when hematopoietic progenitor cells were present, enhanced erythroid commitment and differentiation.

  10. Hereditary persistence of fetal hemoglobin (show HBB Antibodies) in two patients with KLF1 haploinsufficiency due to 19p13.2-p13.12/13 deletion

Mouse (Murine) Kruppel-Like Factor 1 (erythroid) (KLF1) interaction partners

  1. KLF1 and KLF3 (show KLF3 Antibodies) bind common as well as unique sites within the erythroid cell genome.

  2. The semi-dominant neonatal anemia (Nan) mutation in the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in the adult and alter correct development in the early embryo.

  3. Point mutations in the erythroid transcription factor, Klf1: one mutation, D11 generates a stop codon in the zinc finger domain and a homozygous null phenotype; another mutation, D45, generates an amino acid transversion (H350R) within a linker between zinc fingers two and three.

  4. Data indicate that PIAS3 (protein inhibitor of activated STAT3 (show PIAS3 Antibodies)) interaction modulates EKLF (erythroid Kruppel-like factor) activity in a promoter-dependent and SUMO-independent manner.

  5. Hemin-induced expression of PlGF (show PGF Antibodies) is abolished in EKLF-deficient erythroid cells but rescued by conditional expression of EKLF.

  6. HIRA (show HIRA Antibodies) is not only critical for beta-globin (show HBB Antibodies) expression but is also required for activation of the erythropoietic regulators EKLF and GATA binding protein 1 (GATA1).

  7. KLF1 and KLF2 (show KLF2 Antibodies) coordinately regulate embryonic erythroid precursor maturation through the regulation of multiple homeostasis-associated genes.

  8. EKLF mRNA has exon skipping only in primary tissues. The splice variant is at a low level in embryonic and adult erythroid cells, and in terminal differentiation. The truncated protein partially encodes a non-erythroid Kruppel-like factor AA sequence.

  9. Dok2 is able to control Klf1 expression by transcriptional regulation through directly binding to its promoter region.

  10. EKLF plays a coordinating role between two different cell types whose interaction provides the optimal environment to generate a mature red blood cell

KLF1 Antigen Profile

Protein Summary

This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.

Gene names and symbols associated with KLF1

  • Kruppel-like factor 1 (erythroid) (KLF-4) antibody
  • Kruppel like factor 1 (KLF1) antibody
  • Kruppel-like factor 1 (erythroid) (Klf1) antibody
  • Kruppel like factor 1 (Klf1) antibody
  • Eklf antibody
  • HBFQTL6 antibody
  • INLU antibody
  • KLF1 antibody
  • Nan antibody

Protein level used designations for KLF1

Kruppel-like factor 1 (erythroid) , Krueppel-like factor 1 , erythroid Kruppel-like factor , erythroid krueppel-like transcription factor , erythroid-specific transcription factor EKLF , monoclonal antibody A3D8 , erythroid transcription factor , neonatal anemia

GENE ID SPECIES
424577 Gallus gallus
468741 Pan troglodytes
100599870 Nomascus leucogenys
10661 Homo sapiens
100174958 Sus scrofa
784295 Bos taurus
16596 Mus musculus
304666 Rattus norvegicus
484924 Canis lupus familiaris
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