Kruppel-Like Factor 1 (erythroid) (KLF1) ELISA Kits

KLF1 encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. Additionally we are shipping KLF1 Antibodies (87) and KLF1 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KLF1 KLF1 10661 Q13351
KLF1 16596  
Anti-Rat KLF1 KLF1 304666  
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Top KLF1 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 5.8 pg/mL 15.62 pg/mL - 1000 pg/mL 96 Tests Log in to see 13 to 16 Days
$757.89
Details

More ELISA Kits for KLF1 Interaction Partners

Human Kruppel-Like Factor 1 (erythroid) (KLF1) interaction partners

  1. KLF1 gene variants are common in Chinese subjects with alpha-thal and increased Hb F levels, and KLF1 gene mutations decreased the red blood cell (RBC) indices in alpha-thal carriers as that in normal adults.

  2. miR-326 suppresses EKLF expression directly by targeting its 3' UTR. In K562 cells, mir-326 overexpression reduced EKLF and increased gamma-globin production, while EKLF inhibition did the opposite.

  3. KLF1 promoted metastasis and invasion via the PI3K/Akt signaling pathway in cervical cancer cells.

  4. 3 new mutations were found KLF1*90A (p.Trp30Ter), KLF*911A (p.Thr304Lys), and KLF1*304C,318G (p. Ser102Pro, Tyr106Ter) in 2 unrelated individuals. 2 others had c.954dupG (p.Arg319Glufs*34), that is, KLF1*BGM06. A child with unexplained anemia had c.973G>A (p.Glu325Lys), associated with congenital dyserythropoietic anemia. The common c.304T>C was found in 2 of 7 samples and 60 of 100 blood donors.

  5. 4 individuals who were Lua and Lub negative were identified from 5420 unrelated blood donors. KLF1 allele with c.199delA and c.304T>C in Exon 2 was identified in one individual, which caused a frameshift at AA67 and formed a new premature stop codon at nucleotide position 708 p.(Gly68AlafsTer236). One KLF1 allele with c.304T>C and c.604G>A was found in another, which resulted which resulted in p.Ser102Pro and p.Gly202A.

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  7. Changes in HbA2 and HbF in alpha thalassemia carriers with KLF1 mutation.

  8. Reduction of KLF1 expression in beta(0)-thalassemia/HbE erythroblasts can increase HbF levels.

  9. Alterations in high HbF levels may be associated with KLF1 gene mutations.

  10. KLF1 enhancer sequence is frequently hypermethylated in juvenile myelomonocytic leukemia.

  11. Findings suggest that the induction of an indel mutation in the Kruppel like factor 1 (KLF1) gene leading to a null allele.

  12. KLF1 is an important genetic factor associated with increased Hb F and in combination with other modifying factors could explain the phenotypic variation of Hb F expression in this common hemoglobinopathy.

  13. Activation of KLF1 at day 10 of the differentiation process when hematopoietic progenitor cells were present, enhanced erythroid commitment and differentiation.

  14. Hereditary persistence of fetal hemoglobin in two patients with KLF1 haploinsufficiency due to 19p13.2-p13.12/13 deletion

  15. NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR

  16. Introduction of the British HPFH mutation into the fetal globin promoter in a human cell model causes elevated fetal globin expression. The British HPFH mutation creates a de novo binding site both in vitro and in vivo for the potent erythroid activator KLF1.

  17. A hypothesis on possible liaisons between mutations in the gene encoding EKLF and resistance to pathogens is presented.

  18. study reports a novel KLF1 mutation codon 211 A-->G (c.632 A>G) in a family with beta-hemoglobinopathy showing a considerable increase in the HbF level, thus supporting the role of KLF1 in hemoglobin switching

  19. seven new alleles in the KLF1 gene, which are presumed to act dominantly to silence LU expression, were identified

  20. The prevalence of the In(Lu) phenotype in the Japanese population was 0.02%, and we identified 13 known and 21 novel KLF1 alleles. The KLF1 mutations cause the reduced expression of the P1 antigen.

Mouse (Murine) Kruppel-Like Factor 1 (erythroid) (KLF1) interaction partners

  1. Results provide new evidence to support a role for KLF1 in the erythroid/megakaryocyte switch, as well as indicating that transcription factor competition is an important regulation mechanism in eukaryotes in vivo.

  2. KLF1 and KLF3 bind common as well as unique sites within the erythroid cell genome.

  3. The semi-dominant neonatal anemia (Nan) mutation in the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in the adult and alter correct development in the early embryo.

  4. Point mutations in the erythroid transcription factor, Klf1: one mutation, D11 generates a stop codon in the zinc finger domain and a homozygous null phenotype; another mutation, D45, generates an amino acid transversion (H350R) within a linker between zinc fingers two and three.

  5. Data indicate that PIAS3 (protein inhibitor of activated STAT3) interaction modulates EKLF (erythroid Kruppel-like factor) activity in a promoter-dependent and SUMO-independent manner.

  6. Hemin-induced expression of PlGF is abolished in EKLF-deficient erythroid cells but rescued by conditional expression of EKLF.

  7. HIRA is not only critical for beta-globin expression but is also required for activation of the erythropoietic regulators EKLF and GATA binding protein 1 (GATA1).

  8. KLF1 and KLF2 coordinately regulate embryonic erythroid precursor maturation through the regulation of multiple homeostasis-associated genes.

  9. EKLF mRNA has exon skipping only in primary tissues. The splice variant is at a low level in embryonic and adult erythroid cells, and in terminal differentiation. The truncated protein partially encodes a non-erythroid Kruppel-like factor AA sequence.

  10. Dok2 is able to control Klf1 expression by transcriptional regulation through directly binding to its promoter region.

  11. EKLF plays a coordinating role between two different cell types whose interaction provides the optimal environment to generate a mature red blood cell

  12. the regulatory mechanisms of the nuclear import of EKLF, which may also be utilized in the nuclear import of other factors

  13. Similar to its role at the beta-globin promoter, KLF1 induces factor recruitment and chromatin changes at the Alad1b promoter in a temporally-specific manner

  14. data support an important role for the KLF1-BCL11A axis in erythroid maturation and developmental regulation of globin expression

  15. KLF1 activates an extensive erythroid gene expression program.

  16. EKLF increases PIT1 expression during RBC maturation by binding to its promoter in vivo.

  17. KLF3 is a feedback repressor that counters the activity of EKLF at selected target genes to achieve normal erythropoiesis

  18. The expression of the Myc gene is synergistically regulated by KLF1 and KLF2, and both factors bind the Myc promoters.

  19. GATA-1, SCL, and Klf1 form an erythroid core transcriptional network by co-occupying >300 genes

  20. KLF1 and KLF2 positively regulate the embryonic and fetal beta-globin genes through direct promoter binding.

KLF1 Antigen Profile

Antigen Summary

This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.

Gene names and symbols associated with KLF1

  • Kruppel-like factor 1 (erythroid) (KLF-4) antibody
  • Kruppel like factor 1 (KLF1) antibody
  • Kruppel-like factor 1 (erythroid) (Klf1) antibody
  • Kruppel like factor 1 (Klf1) antibody
  • Eklf antibody
  • HBFQTL6 antibody
  • INLU antibody
  • KLF1 antibody
  • Nan antibody

Protein level used designations for KLF1

Kruppel-like factor 1 (erythroid) , Krueppel-like factor 1 , erythroid Kruppel-like factor , erythroid krueppel-like transcription factor , erythroid-specific transcription factor EKLF , monoclonal antibody A3D8 , erythroid transcription factor , neonatal anemia

GENE ID SPECIES
424577 Gallus gallus
468741 Pan troglodytes
100599870 Nomascus leucogenys
10661 Homo sapiens
100174958 Sus scrofa
784295 Bos taurus
16596 Mus musculus
304666 Rattus norvegicus
484924 Canis lupus familiaris
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