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KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). Additionally we are shipping KLF13 Kits (6) and KLF13 Proteins (2) and many more products for this protein.
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KLF13 functions as a tumor suppressor protein (show TP53 Antibodies) in PCa (show FLVCR1 Antibodies), and the pharmacological activation of KLF13 might represent a potential approach for the treatment of prostate cancer.
Our results suggest the cg07814318 site could be involved in orexigenic (show GHRL Antibodies)processes, and also implicate KLF13 in obesity. Our findings are the first to associate methylation levels in blood with brain activity in obesity-related regions, and further support previous findings between ghrelin, brain activity and genetic differences.
SLC44A1 (show SLC44A1 Antibodies) and KLF13 may be involved in tumorigenesis and the metastasis of colon cancer by miRNA regulation
KLF13 is critical for the activation of the HPV productive life cycle and is likely involved in initiation and progression of cervical cancer.
Knoc (show FBXW7 Antibodies)kdown of either FBW7gamma or GSK3beta by small interferin (show CCL5 Antibodies)g RNA increases KLF13 expression in resting human T lymphocytes.
No associations were found between maternal genetic polymorphisms in RANTES (show CCL5 Antibodies) (-403G/A) and mother-to-child HIV-1 transmission; plasma, cervical and breastmilk viral loads; or breastmilk chemokine (show CCL1 Antibodies) concentrations.
KLF13 contributes to malignancy in oral cancer cells and may be a useful biomarker fo early detection and da possible target for therapy.
Data support cross-regulation among BMP2 (show BMP2 Antibodies), KLF9 (show KLF9 Antibodies), and KLF13 to maintain progesterone sensitivity in stromal cells undergoing differentiation and suggest that loss of this network compromises establishment of uterine receptivity and implantation success.
protein analysis of BTEB3 and BTEB4 (show KLF16 Antibodies) and their binding to CYP1A1 (show CYP1A1 Antibodies)
A translational rheostat for RFLAT-1 regulates RANTES (show CCL5 Antibodies) expression in T lymphocytes.
Methylation levels at cg07814318 also positively correlated with ghrelin (show GHRL Antibodies) levels. Moreover, expression of KLF13 was augmented in the brains of obese and starved mice
These results established a novel role for GR and KLF13 signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.
The data also suggest that, in human, KLF13 may be a genetic modifier of the Holt-Oram Syndrome gene TBX5 (show TBX5 Antibodies).
Results demonstrate lack of a causative relationship between endometrial KLF13 deficiency and lesion establishment in mice, and they support the broader participation of multiple signaling pathways in the pathology of endometriosis.
KLF13 directly binds to IL-4 (show IL4 Antibodies) promoter regions and synergizes with c-Maf (show MAF Antibodies) to positively regulate IL-4 (show IL4 Antibodies) expression.
Fbw7 (show FBXW7 Antibodies) gamma - mediated ubiquitination of KLF13 prevents RANTES (show CCL5 Antibodies) expression in resting human but not murine T lymphocytes.
KLF13 sustains thymic memory-like CD8 (show CD8A Antibodies)(+) T cells in BALB/c mice by regulating IL-4 (show IL4 Antibodies)-generating invariant natural killer T cells.
KLF13 binds to multiple sites within the Bcl-X(L (show BCL2L1 Antibodies)) promoter and results in decreased Bcl-X(L (show BCL2L1 Antibodies)) promoter activity, making KLF13 a negative regulator of BCL-X(L (show BCL2L1 Antibodies)).
KLF13 and SREBP-Sp1 (show SP1 Antibodies) activation interact to regulate low density lipoprotein receptor (show LDLR Antibodies) promoter function
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000
Kruppel-like factor 13
, Krueppel-like factor 13
, Kruppel-like factor 13 like
, BTE-binding protein 3
, RANTES factor of late activated T lymphocytes-1
, RANTES factor of late activated T-lymphocytes 1
, Sp1 like zinc finger transcription factor
, basic transcription element binding protein 3
, basic transcription element-binding protein 3
, novel Sp1-like zinc finger transcription factor 1
, transcription factor BTEB3
, transcription factor NSLP1
, C2-H2 zinc finger protein
, erythroid transcription factor FKLF-2