Kruppel-Like Factor 13 (KLF13) ELISA Kits

Human Kruppel-Like Factor 13 (KLF13) interaction partners

1. Results show that cg07814318 methylation in blood was significantly associated with obesity and correlated with several obesity-related physical and biochemical traits. The exome sequencing of KLF13 gene in blood identified nine SNPs within its gene body, and two SNPs as cis-meQTL of cg07814318. The sequencing variations within KLF13 genes could drive dynamic modifications of obesity-related CpG methylation.

2. KLF13 functions as a tumor suppressor protein in PCa, and the pharmacological activation of KLF13 might represent a potential approach for the treatment of prostate cancer.

3. Our results suggest the cg07814318 site could be involved in orexigenic processes, and also implicate KLF13 in obesity. Our findings are the first to associate methylation levels in blood with brain activity in obesity-related regions, and further support previous findings between ghrelin, brain activity and genetic differences.

4. SLC44A1 and KLF13 may be involved in tumorigenesis and the metastasis of colon cancer by miRNA regulation

5. KLF13 is critical for the activation of the HPV productive life cycle and is likely involved in initiation and progression of cervical cancer.

6. Knockdown of either FBW7gamma or GSK3beta by small interfering RNA increases KLF13 expression in resting human T lymphocytes.

7. No associations were found between maternal genetic polymorphisms in RANTES (-403G/A) and mother-to-child HIV-1 transmission; plasma, cervical and breastmilk viral loads; or breastmilk chemokine concentrations.

8. KLF13 contributes to malignancy in oral cancer cells and may be a useful biomarker fo early detection and da possible target for therapy.

9. Data support cross-regulation among BMP2, KLF9, and KLF13 to maintain progesterone sensitivity in stromal cells undergoing differentiation and suggest that loss of this network compromises establishment of uterine receptivity and implantation success.

10. protein analysis of BTEB3 and BTEB4 and their binding to CYP1A1

11. functional domains and DNA-binding sequences

12. A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.

13. Feedback mechanism for the transcriptional control of the KLF13 gene in the erythroid environment.

14. In co-transfection assays in K562 cells, it was demonstrated that KLF2, 5 and 13 positively regulate, and KLF8 negatively regulates, the gamma-globin gene through the CACCC promoter element.

15. KLF13 is a key regulator of late RANTES expression in T lymphocytes

16. Coexpression of PRP4 and KLF13 increases nuclear localization of KLF13 and CCL5 transcription.

17. Transient transfection of Kruppel-like factor 4 suppressed LDLR, steroidogenic acute regulatory protein, and CYP11A

Mouse (Murine) Kruppel-Like Factor 13 (KLF13) interaction partners

1. the improvement of cardiac function and structure elicited by miR-125b-5p is in part attributed to repression of the pro-apoptotic genes Bak1 and Klf13 in cardiomyocytes.

2. Methylation levels at cg07814318 also positively correlated with ghrelin levels. Moreover, expression of KLF13 was augmented in the brains of obese and starved mice

3. These results established a novel role for GR and KLF13 signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.

4. The data also suggest that, in human, KLF13 may be a genetic modifier of the Holt-Oram Syndrome gene TBX5.

5. Results demonstrate lack of a causative relationship between endometrial KLF13 deficiency and lesion establishment in mice, and they support the broader participation of multiple signaling pathways in the pathology of endometriosis.

6. KLF13 directly binds to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression.

7. Fbw7 gamma - mediated ubiquitination of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.

8. KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.

9. Data support cross-regulation among BMP2, KLF9, and KLF13 to maintain progesterone sensitivity in stromal cells undergoing differentiation and suggest that loss of this network compromises establishment of uterine receptivity and implantation success.

10. A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.

11. KLF13 binds to multiple sites within the Bcl-X(L) promoter and results in decreased Bcl-X(L) promoter activity, making KLF13 a negative regulator of BCL-X(L).

12. These data indicate that KLF13 is involved in the normal control of erythropoiesis.

13. findings show KLF13 is involved at multiple different checkpoints in B and T cell development that require signalling through the TCR, pre-BCR or mature BCR

Pig (Porcine) Kruppel-Like Factor 13 (KLF13) interaction partners

1. KLF13 and SREBP-Sp1 activation interact to regulate low density lipoprotein receptor promoter function