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KLF6 encodes a member of the Kruppel-like family of transcription factors. Additionally we are shipping KLF6 Proteins (12) and many more products for this protein.
Showing 10 out of 47 products:
Human Monoclonal KLF6 Primary Antibody for IHC, WB - ABIN2668584
Narla, DiFeo, Yao, Banno, Hod, Reeves, Qiao, Camacho-Vanegas, Levine, Kirschenbaum, Chan, Friedman, Martignetti: Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread. in Cancer research 2005
Show all 2 Pubmed References
Human Monoclonal KLF6 Primary Antibody for ELISA, WB - ABIN560438
Lin, Jiang, Chuu: Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells. in PLoS ONE 2012
Human Polyclonal KLF6 Primary Antibody for FACS, IF - ABIN390515
Sangodkar, Shi, DiFeo, Schwartz, Bromberg, Choudhri, McClinch, Hatami, Scheer, Kremer-Tal, Martignetti, Hui, Leung, Friedman, Narla: Functional role of the KLF6 tumour suppressor gene in gastric cancer. in European journal of cancer (Oxford, England : 1990) 2009
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DJ-1 (show PARK7 Antibodies) knockdown increased KLF6 expression in bortezomib-resistant myeloma cells, and subsequent siRNA-mediated KLF6 knockdown rescued bortezomib-resistant myeloma cells from undergoing cell death.
Our study provides new evidence that interaction of KLF6 and Sp1 regulates basigin-2 expression in hepatocellular carcinoma
MIIP (show MIIP Antibodies) and PAK1 (show PAK1 Antibodies) bind each other and a C-terminal polyproline domain of MIIP (show MIIP Antibodies) is required for PAK1 (show PAK1 Antibodies) binding. Ectopically expressed MIIP (show MIIP Antibodies) consistently competed with Rac1-GTP (show AK3 Antibodies) for binding with the PAK1 (show PAK1 Antibodies) p21 (show CDKN1A Antibodies)-binding domain in endometrial cancer cells.
hypoxia induced an early and transient increase in KLF6 protein levels in HTR8/SVneo extravillous cytotrophoblast cells and in placental explants. Reoxygenation returned KLF6 protein to basal levels. Moreover, hypoxia-induced up-regulation of KLF6 expression was dependent on HIF-1alpha (show HIF1A Antibodies). These results indicate that KLF6 may mediate some of the effects of hypoxia in placental development.
The study highlights the central role of myeloid KLF6 in promoting intestinal inflammation.
study identifies a new mechanism by which KLF6 regulates NF-kappaB (show NFKB1 Antibodies) signaling, and how this mechanism is circumvented in glioblastoma through KLF6 loss.
our results established the significance of activating the KLF6-E2F1 (show E2F1 Antibodies) axis in aggressive primary metastatic clear cell renal cell carcinoma (show MOK Antibodies)
KLF6 overexpression suppressed the xenograft tumor growth.
KLF6 and KLF15 (show KLF15 Antibodies) are targeted and suppressed in breast cancer cells by miR (show MLXIP Antibodies)-4262.
KLF6 acts as a tumor suppressor in CMM cells and miR (show MLXIP Antibodies)-4262 promotes the proliferation of CMM cells through KLF6-mediated EGFR (show EGFR Antibodies) inactivation and p21 (show CDKN1A Antibodies) upregulation.
KLF6-mediated activation of the human INSL3 (show INSL3 Antibodies) promoter required an intact KLF element as well as Leydig/Sertoli-enriched factors. KLF6 transcriptionally cooperates with NUR77 (show NR4A1 Antibodies) and SF1 (show SF1 Antibodies). our results identify KLF6 as a regulator of human INSL3 (show INSL3 Antibodies) transcription.
we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.
Klf6 as required for developmental central nervous system myelination.Klf6 promotes oligodendrocyte differentiation and viability.
observations reveal that KLF6 repress BCL6 (show BCL6 Antibodies) to enhance macrophage inflammatory gene expression and function.
present studies on the cardiac function of KLF6 show a new mechanism whereby cardiomyocytes regulate cardiac fibrosis through transcriptional control of the extracellular matrix factor thrombospondin 4 (show THBS4 Antibodies)
downregulates expression and secretion of granulocyte macrophage colony-stimulating factor (show CSF2 Antibodies)
KLF6-dependent regulation of the cytochrome c (show CYCS Antibodies) oxidase assembly gene is critical for maintaining mitochondrial function and preventing podocyte apoptosis.
findings provide novel evidence highlighting KLF6 function in response to malignant transformation, suggesting the relevance of KLF6 in controlling cell proliferation and hindering tumorigenesis
KLF6 is required for optimal LPS (show TLR4 Antibodies)-induced pro-inflammatory gene expression, acting cooperatively with NF-kappaB (show NFKB1 Antibodies)
Klf6a promotes hematopoietic stem and progenitor cell maintenance through Ccl25b-Ccr7 (show CCR7 Antibodies) chemokine (show CCL1 Antibodies) signaling.
In the spinal cord, klf7 (show KLF7 Antibodies)- and klf6a-expressing cells are found in both the dorsal and ventral horns. Numerous sensory structures (e.g. auditory, lateral line, olfactory and visual) and several motor nuclei (e.g. oculomotor, trigeminal, and vagal motor nuclei) contain klf7 (show KLF7 Antibodies)- and/or klf6a-expressing cells
copeb/Klf6 is essential for the development of endoderm-derived organs
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis.
Kruppel-like factor 6
, core promoter element binding protein
, Krueppel-like factor 6
, krueppel-like factor 6
, B-cell-derived protein 1
, GC-rich binding factor
, GC-rich sites-binding factor GBF
, Kruppel-like zinc finger protein Zf9
, core promoter element-binding protein
, proto-oncogene BCD1
, protooncogene B-cell derived 1
, suppression of tumorigenicity 12 (prostate)
, suppressor of tumorigenicity 12 protein
, transcription factor Zf9
, immediate early response, erythropoietin 1