Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase) (KMO) ELISA Kits

KMO encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Additionally we are shipping KMO Antibodies (74) and KMO Proteins (14) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
KMO 98256 Q91WN4
KMO 59113 O88867
KMO 8564 O15229
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Top KMO ELISA Kits at antibodies-online.com

Showing 4 out of 21 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Rat 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Human 0.3 ng/mL 0.78 ng/mL - 50 ng/mL 96 Tests 13 to 16 Days
$736.84
Details
Mouse
  96 Tests 11 to 18 Days
$682.25
Details
Pig
  96 Tests 15 to 18 Days
$1,029.60
Details

More ELISA Kits for KMO Interaction Partners

Mouse (Murine) Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase) (KMO) interaction partners

  1. Study shows that the development of depression-like behavior in the spared nerve injury model requires brain interleukin-1 signaling and activation of neuronal kynurenine 3-monoxygenase, while pain is independent of this pathway.

  2. results demonstrate that the elimination of Kmo in mice is associated with multiple gene and functional alterations that appear to duplicate aspects of the psychopathology of several neuropsychiatric disorders.

  3. These results suggest that increased KP metabolites reduced chemokine production, resulting in suppressed mortality upon KMO knockdown in EMCV infection. KP metabolites may thus provide an effective strategy for treating acute viral myocarditis.

  4. The findings of this study suggested that KMO KO mice show antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions via abnormality of kynurenine metabolism with good validities as Major depressive disorder model.

  5. Our data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes

  6. Mice lacking the enzyme kynurenine-3-monoxygenase (KMO) also showed no changes in hippocampal expression of several of these proteins or the 70-kDa and 100-kDa variants of Disrupted in Schizophrenia-1 (DISC1).

  7. KMO KO mice have a robust biochemical phenotype that protects against extrapancreatic tissue injury to the lung, kidney and liver in experimental acute pancreatitis-multiple organ dysfunction syndrome.

  8. KMO knockout mice have alterations in the levels of several tryptophan metabolites.

  9. expression of KMO by Th17 cells serves to limit their continuous exposure to physiological levels of endogenous aryl hydrocarbon receptor ligands in vivo.

  10. partial protection against cerebral malaria was observed in C57BL/6 mice treated with Ro 61-8048, an inhibitor of kynurenine-3-hydroxylase. Protection was associated with suppressed levels of picolinic acid within the brain.

Human Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase) (KMO) interaction partners

  1. There is the association between the rs1053230 polymorphism and depression.

  2. results show the incidence of Postpartum Depression in the Chinese population to be 7.3%, with PDS characterized by increased serum 3-HydroxyKinurenine concentration and 3-HK/Kynurenine ratio, versus matched postpartum women without PDS. Furthermore, polymorphisms of Kynurenine Monooxygenase rs1053230 are significantly associated with the incidence of PDS.

  3. Our data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes

  4. A comprehensive review of the molecular properties of KMO, including its kinetics, reaction mechanism, and inhibitor structure-activity relationship (SAR), is not currently available and, thus, is our focus here

  5. SiRNA knockdown of the pathway components Kynurenine 3-monooxygenase and quinolinate phosphoribosyl transferase caused cells to revert to a state of susceptibility to 3HK-mediated apoptosis.

  6. These results suggest that KMO exhibits tumor-promoting effects towards hepatocellular carcinoma (HCC) and it may serve as a novel prognostic marker in HCC.

  7. Results suggest that KMO variation influences a range of cognitive domains known to predict functional outcome in schizophrenia

  8. Two KMO SNPs were observed more often in schizophrenia patient group compared with healthy controls.

  9. findings from five independent cohorts suggest that genetic variation in KMO influences the risk for psychotic features in mania of bipolar disorder patients.

  10. Study reporting on the first successful bacterial (Escherichia coli) expression of active FLAGtrade mark-tagged human KMO enzyme expressed in the soluble fraction and progress towards its purification.

  11. analyzed association between KMO gene polymorphisms and CSF concentrations of kynurenic acid in patients with schizophrenia and controls. results suggest that the nonsynonymous KMO SNP rs1053230 influences CSF concentrations of KYNA.

  12. significant and correlated reduction in gene expression and enzyme activity in the frontal eye field in schizophrenia patients; rs2275163 has modest effects on predictive pursuit and visuospatial working memory endophenotypes

  13. The present analysis of the combined Scandinavian sample did not reveal any allele frequency difference between patients and healthy controls

  14. the function KMO AND indoleamine 2,3-dioxygenase may change from a role in immunosuppression at the maternal-fetal interface in early pregnancy, to one associated with regulation of fetoplacental blood flow or placental metabolism in late gestation

  15. Results suggest that kynurenine 3-monooxygenase is unlikely to be related to the development of schizophrenia in Japanese.

Pig (Porcine) Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase) (KMO) interaction partners

  1. The carboxyl-terminal region of pig liver L-kynurenine 3-monooxygenase plays a dual role as a mitochondrial-targeting signal and an enzyme.

KMO Antigen Profile

Antigen Summary

This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease.

Gene names and symbols associated with KMO

  • kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo) antibody
  • kynurenine 3-monooxygenase (Kmo) antibody
  • kynurenine 3-monooxygenase (KMO) antibody
  • AI046660 antibody
  • dJ317G22.1 antibody

Protein level used designations for KMO

kynurenine 3-hydroxylase , kynurenine 3-monooxygenase , L-kynurenine 3-monooxygenase Fpk , fpk

GENE ID SPECIES
98256 Mus musculus
59113 Rattus norvegicus
8564 Homo sapiens
397148 Sus scrofa
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