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Involved in nuclear structure organization.. Additionally we are shipping LEMD2 Proteins (3) and many more products for this protein.
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We conclude that Lem2p/LEM2 is a conserved nuclear site-specific adaptor that recruits Cmp7p/CHMP7 (show CHMP7 Antibodies) and downstream ESCRT factors to the nuclear envelope.
we expressed a LEMD2 transgene alone or in combination with lamin C in these cells and observed no restoration of peripheral heterochromatin in either case. We conclude that in contrary to the B-tether, the A-tether has a more intricate composition and consists of multiple components that presumably vary, at differing degrees of redundancy, between cell types and differentiation stages
Lemd2 is required for embryonic development in mouse and its loss is associated with highly elevated activity of AKT (show AKT1 Antibodies) and MAP kinases.
Deregulation of cell signaling contributes to nuclear envelope-linked disorders and suggests that mutations in NET25 and MAN1 (show LEMD3 Antibodies) may cause muscle diseases.
Involved in nuclear structure organization.
LEM domain containing 2
, LEM domain-containing protein 2
, nuclear envelope constituent