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LHX3 encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. Additionally we are shipping LHX3 Kits (10) and LHX3 Proteins (7) and many more products for this protein.
Showing 10 out of 26 products:
investigated the specific mutations in PROP1 (show PROP1 Antibodies), POU1F1 (show POU1F1 Antibodies), LHX3, and HESX1 (show HESX1 Antibodies) genes in patients with combined pituitary hormone (show CGA Antibodies) deficiency (CPHD) in Turkey
LHX3 is upregulated in high-grade oligodendroglioma.
The downstream enhancer region of LHX3 in regulating gene expression at the cellular level during development, is reported.
Data suggest that low serum FSH (show BRD2 Antibodies) (follicle stimulating hormone) levels in men with SNP in promoter region of FSHB (FSH beta (show FSHB Antibodies) subunit (show POLG Antibodies); -211G/T) result from reduced LHX3 binding to FSHB (show FSHB Antibodies) promoter and down-regulation of FSHB (show FSHB Antibodies) transcription in gonadotrophs.
The present study was unable to confirm a significant association of all of the three SNPs, rs12338076 in LHX3-QSOX2 (show QSOX2 Antibodies), and rs1457595 and rs17032362 in IGF1 (show IGF1 Antibodies), with adult height in our study population.
descriprion of pediatric patients with combined pituitary hormone (show CGA Antibodies) deficiency with a novel mutation in LHX3; the T194R mutation affects a critical residue in the LHX3 protein; study extends understanding of phenotypic features, molecular mechanism and developmental course associated with mutations in the LHX3 gene
This study of the first nonconsanguineous patient with LHX3 mutations demonstrates the pleiotropic roles of LHX3 during development and its full involvement in the complex disease phenotype of syndromic combined pituitary hormone (show CGA Antibodies) deficiency.
This study establishes ISL1 (show ISL1 Antibodies) as a novel transcriptional regulator of LHX3 and describes a potential mechanism for regulation by PITX1 (show PITX1 Antibodies).
LHX3 mutations are a rare cause of hypopituitarism. We report on a patient with a novel LHX3 mutation in exon 2 with the phenotype of combined pituitary hormone (show CGA Antibodies) deficiency with short neck and sensorineural hearing impairment. [review]
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 (show QSOX2 Antibodies) and IGF1 (show IGF1 Antibodies) as adult height loci.
Lhx3 and Lhx4 (show LHX4 Antibodies) have roles in suppressing Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons
LHX3 LIM homeodomain (show LHX2 Antibodies) transcription factor is involved in activation of the FSH beta (show FSHB Antibodies)-subunit (show POLG Antibodies) gene in the pituitary gonadotrope cell.
Association analysis indicated that the some SNPs studied are associated with the body weight at 6, 12 and 18months of age in Nanyang cattle (P<0.01 or P<0.05), providing evidence that some SNPs in LHX3 gene may be associated with body weight at certain ages.
The isolation and characterization of three polymorphisms of LHX3 are reported.
Results show that specific genomic loci associated with Islet-1 (Isl1 (show ISL1 Antibodies)) , LIM-homeobox 3 (Lhx3), and LMO4 (show LMO4 Antibodies) genes recruit the Isl1 (show ISL1 Antibodies)-Lhx3 complex to activate the transcription of Isl1 (show ISL1 Antibodies), Lhx3, and Lmo4 (show LMO4 Antibodies).
Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 (show PAX6 Antibodies) and the LIM protein (show PDLIM1 Antibodies) complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation.
conditional deletion of Shh (show SHH Antibodies) in the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest of (Rathke's pouch) RP development, with lack of Lhx3/Lhx4 (show LHX4 Antibodies) expression in RP epithelium.
Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1 (show ISL1 Antibodies)/Lhx3 in nascent motor neurons and Isl1 (show ISL1 Antibodies)/Onecut1 (show ONECUT1 Antibodies) in maturing hypaxial motor neurons.
All E1 sequences from lamprey to mouse responded equally well to Phox2a (show PHOX2A Antibodies) and the Isl1 (show ISL1 Antibodies)-Lhx3 complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals
We discovered that expression of Cdkn1a (show CDKN1A Antibodies) is expanded dorsally in the pituitary primordium of both Lhx3 and Lhx4 (show LHX4 Antibodies) mutants.
Lhx3-LIM (show PDLIM5 Antibodies) domains play critical roles in transactivation of the Isl1 (show ISL1 Antibodies)-Lhx3 complex by not only directing the assembly of the Isl1 (show ISL1 Antibodies)-Lhx3 complex but also recruiting coactivators to the complex.
This treatment leads to activation of Lhx3 gene expression.
LHX3 interacts with inhibitor of histone acetyltransferase (show HAT Antibodies) complex subunits LANP (show ANP32A Antibodies) and TAF (show TAF8 Antibodies)-1beta to modulate pituitary gene regulation.
The results of this study suggested that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.
This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants.
lim homeobox 3
, LIM homeobox 3
, LIM homeobox protein 3
, LIM/homeobox protein Lhx3
, LIM/homeodomain protein LHX3
, homeobox protein LIM-3
, LIM homeodomain protein 3
, LIM homeodomain 3 protein b isoform
, LIM homeo box protein 3
, homeobox protein P-LIM