LIM Homeobox 4 Proteins (LHX4)

LHX4 encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. Additionally we are shipping LHX4 Antibodies (67) and LHX4 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LHX4 89884 Q969G2
Rat LHX4 LHX4 360858  
LHX4 16872 P53776
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Top LHX4 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

LHX4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for LIM Homeobox 4 (LHX4) Interaction Partners

Zebrafish LIM Homeobox 4 (LHX4) interaction partners

  1. Lhx3 and Lhx4 have roles in suppressing Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons

Human LIM Homeobox 4 (LHX4) interaction partners

  1. LHX4 Mutation is associated with Pituitary Deficits.

  2. The study identified 4 new LHX4 heterozygous allelic variants in patients with congenital hypopituitarism: W204X, delK242, N271S and Q346R.

  3. A novel homozygous mutation in LHX4 associated with a lethal phenotype, implying that recessive mutations in LHX4 may be incompatible with life.

  4. we found that LHX4 upregulated beta-catenin levels in human colorectal cancer cell lines

  5. Data indicate that HESX1, LHX4 and SOX3 polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).

  6. This study is the first to describe, a gradual loss of ACTH in a patient carrying an LHX4 mutation.

  7. Variably penetrant pituitary insufficiency, including this severe and atypical presentation, can be correlated with LHX4 insufficiency and highlights the role of LHX4 for pituitary development.

  8. data indicate that LHX4 may act as a potential tumor suppressor in hepatocarcinogenesis, suggesting that targeting LHX4 to downregulate AFP might have therapeutic implications

  9. A novel HESX1 causative mutation was found in a consanguineous family, and two LHX4 mutations were present in familial Pituitary stalk interruption syndrome.

  10. "Heterozygous splice site mutations within LHX4 are associated with combined pituitary hormone deficiency and isolated growth hormone deficiency... small sella turcica...persistent craniopharyngeal canal...ectopic posterior pituitary... " P. 207

  11. LHX4 expression is transient, and, at 6 weeks of development, is stronger at the caudal than at the cervical level.

  12. Findings are consistent with the existence of LHX4-driven pathway leading to expression of GH through transcriptional activation of POU1F1. They argue against dominant-negative effect of mutant LHX4 proteins over normal LHX4.

  13. endogenous LHX4 binds to the CGA promoter and that LHX4-mediated CGA activation is enhanced by the SS18-SSX protein

  14. We conclude Sp1 directly regulates Lhx4 gene expression.

  15. LHX4 mutations are a relatively rare cause of combined pituitary hormone deficiency.

  16. three new exonic LHX4 allelic variants with at least one being responsible for congenital hypopituitarism.

  17. In mice, a similar protein plays a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.

  18. germline mutations; phenotype characterized by short stature and by pituitary, hindbrain, and skull abnormalities

Cow (Bovine) LIM Homeobox 4 (LHX4) interaction partners

  1. some polymorphisms in LHX4 are associated with growth traits at certain ages, and may be used as candidates for marker-assisted selection and management

  2. The animals with genotype GA had greater body weight than those with genotype GG (P < 0.05); the animals with GA genotype owned significantly longer body length than the ones with GG genotype (P < 0.05) at 18 and 24 months.

Mouse (Murine) LIM Homeobox 4 (LHX4) interaction partners

  1. conditional deletion of Shh in the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest of (Rathke's pouch) RP development, with lack of Lhx3/Lhx4 expression in RP epithelium.

  2. We discovered that expression of Cdkn1a is expanded dorsally in the pituitary primordium of both Lhx3 and Lhx4 mutants. Lhx4 mutants exhibit reduced cyclin D1 expression and have auxiliary pouch-like structures.

  3. X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4.Isl2 complex exhibit many similarities with that of Lhx3.Isl1; structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.

  4. Lhx4 and Prop1 have critical, but mechanistically different roles in specification and expansion of specialized anterior pituitary cells

  5. We conclude Sp1 directly regulates Lhx4 gene expression.

  6. Results show that Lhx3 exhibits specific spatial and temporal expression in the mouse placenta, but that absence of both LHX3 and 4 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr.

  7. Successful purification and crystallization of an engineered complex comprising the LIM domains of motor neuron protein Lhx4 and the Lim binding domain of Isl2 (islet 2 protein) are reported.

LHX4 Protein Profile

Protein Summary

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4.

Gene names and symbols associated with LIM Homeobox 4 Proteins (LHX4)

  • LIM homeobox 4 (LHX4)
  • LIM homeobox 4 (lhx4)
  • LIM homeobox 4 (Lhx4)
  • LIM homeobox protein 4 (Lhx4)
  • A330062J17Rik protein
  • CPHD4 protein
  • Gsh-4 protein
  • Gsh4 protein
  • LHX4 protein
  • si:dkeyp-35f11.3 protein

Protein level used designations for LIM Homeobox 4 Proteins (LHX4)

LIM homeobox 4 , LIM homeobox protein 4 , LIM/homeobox protein Lhx4 , LIM/homeobox protein Lhx4-like , LIM homeo box protein 4

469601 Pan troglodytes
571943 Danio rerio
100460807 Pongo abelii
89884 Homo sapiens
490300 Canis lupus familiaris
540797 Bos taurus
360858 Rattus norvegicus
776024 Gallus gallus
100727880 Cavia porcellus
101122876 Ovis aries
16872 Mus musculus
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