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Members of the LY6 protein family (see SLURP1\; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010].. Additionally we are shipping LYPD6 Antibodies (10) and LYPD6 Proteins (4) and many more products for this protein.
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Lypd6 appears to control Lrp6 activation specifically in membrane rafts, which is essential for downstream signaling.
the Lynx protein Lypd6 binds to nAChRs in human brain extracts, and that recombinant Lypd6 decreases nicotine-induced ERK phosphorylation
The cloning and characterization of a novel human LU domain containing gene, LYPD6, isolated from human testis cDNA library, is reported.
Study employ the marble burying (MB) and elevated zero maze (EZM) tests in Lypd6 knock-out (KO) and wild-type (WT) mice and find that loss of Lypd6 leads to decreased digging behaviour in the MB test and increased time spent in the open area in the EZM test; demonstrate that acute nicotine administration reduces digging in the MB test in both KO and WT mice and further accentuates the inherent genotype difference.
Lypd6 seems to constitute a novel modulator of nAChRs that affects receptor function by selectively increasing Ca2+-influx through ion channels
Members of the LY6 protein family (see SLURP1\; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010
ly6/PLAUR domain-containing protein 6
, LY6/PLAUR domain containing 6
, ly6/PLAUR domain-containing protein 6-like