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Lbx1 and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes.
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Two single nucleotide polymorphisms around LBX1 are associated with adolescent idiopathic scoliosis in a Northern Chinese Han population.
Meta-analysis provides evidence that rs111090870, rs678741 and rs625039 polymorphisms near LBX1 gene are associated with adolescent idiopathic scoliosis susceptibility in some populations.[meta-analysis]
LBX1 is a susceptibility gene for idiopathic scoliosis in a Scandinavian population.
In embryos overexpressing lbx1b, wnt5b (show WNT5B Proteins), a ligand of the non-canonical Wnt (show WNT2 Proteins)/planar cell polarity (PCP (show PRCP Proteins)) pathway, was significantly downregulated.
Our results identify two clinically relevant haplotypes in the LBX1-region with opposite effects on AIS (show AR Proteins) risk.
Based on meta-analysis rs11190870 near LBX1 is likely a susceptibility variant for adolescent idiopathic scoliosis in East Asians.
Performed a meta-analysis of the LBX1 locus in six Asian and three non-Asian cohorts of adolescent idiopathic scoliosis (AIS (show AR Proteins)) and found significant evidence for association of this locus with AIS (show AR Proteins) susceptibility in all nine cohorts.
The SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of adolescent idiopathic scoliosis in Han Chinese adolescents.
This study shows that the genetic variants near the LBX1 gene are associated with adolescent idiopathic scoliosis susceptibility in Chinese Han population.
Single nucleotide polymorphism near LBX1 is significantly associated with adolescent idiopathic scoliosis in southern Chinese.
Lbx1 gene might be a candidate gene of carcass traits and provide useful information for further studies on its roles in porcine skeletal muscle.
Chmp2b (show CHMP2B Proteins) is one of the most highly regulated cell-autonomous targets of Lbx1 in the embryonic mouse neural tube
Lbx1 is expressed in and required for the correct specification of three early dorsal interneuron populations and late-born neurons that form the substantia gelatinosa. Lbx1 plays a critical role in the development of sensory pathways in the spinal cord.
Lbx1 is required for correct dorsal-ventral patterning of the neural tube. Lbx1/Pax3 (show PAX3 Proteins) double-mutant mice showed a completely open neural tube.
Inactivation of the Lbx1 gene in mice resulted in defects in heart looping, changes in gene expression pattern, and increased cell division; Pax3 (show PAX3 Proteins) and Lbx1 participate in negative regulatory feedback
Corl1 interacted with Lbx1 and cooperatively repressed transcription, suggesting that it acts as a transcriptional corepressor for Lbx1 in regulating cell fate determination in the dorsal spinal cord.
Lbx1 and Tlx3 (show TLX3 Proteins) are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes.
Homeobox (show PRRX1 Proteins) gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain.
Functional analysis of homeodomain-containing transcription factor Lbx1 in satellite cells of mouse skeletal muscle is reported.
The respiratory rhythm generation within the pre-Botzinger complex (preBotC) is presumably functional in Lbx1 mutant mice with additional neurochemical drive.
This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.
lady bird-like homeobox
, ladybird homeobox homolog 1
, ladybird homeobox protein homolog 1
, transcription factor LBX1
, transcription factor similar to D. melanogaster homeodomain protein lady bird late
, lady bird-like homeobox 1 homolog
, ladybird homeobox 1a