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Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.. Additionally we are shipping Laminin alpha 1 Kits (20) and Laminin alpha 1 Proteins (8) and many more products for this protein.
Showing 10 out of 60 products:
Laminin regulates PDGFRbeta cell differentiation, fate determination, cell stemness and muscle development via gpihbp1 (show GPIHBP1 Antibodies).
while MMP-9 (show MMP9 Antibodies) is not essential for hypoxic-induced cerebral angiogenesis, it plays an important role in post-hypoxic vascular pruning by degrading laminin and claudin-5 (show CLDN5 Antibodies)
interaction of alpha6beta1 in embryonic stem cells (ECCs) with laminin-1 activates alpha6beta1/CD151 (show CD151 Antibodies) signaling which programs ESCs (show NR2E3 Antibodies) toward the endothelial cells lineage fate
These findings suggest that LAMA1 plays a critical role in kidney function and kidney aging by regulating the mesangial cell population and mesangial matrix deposition through TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling.
Mutations in Lama1 allow developing retinal vessels to enter the vitreous where they anastomose with vessels of the hyaloid system which persist and expand
Our data show that the absence of Lama1 has an impact on the Bergmann glia scaffold that aberrantly develops.
Laminin alpha1 chain is not responsible for muscle disease in the mdx (show DMD Antibodies) mouse model for Duchenne muscular dystrophy (show DMD Antibodies)
This first report of viable Lama1 mouse mutants emphasizes the importance of this gene in retinal development, and data suggest that hypomorphic mutations in human LAMA1 could lead to retinal disease.
Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 (show MMP9 Antibodies) expression.
mouse laminin alpha 1 gene has an upstream enhancer that defines its expression in parietal endoderm cells
We report here a severe defect of neuromuscular transmission in a consanguineous patient with a homozygous variant in the laminin alpha-5 (show LAMA5 Antibodies) subunit gene (LAMA5 (show LAMA5 Antibodies)). The variant c.8046C>T (p.Arg2659Trp) is rare and has a predicted deleterious effect. The affected individual, who also carries a rare homozygous sequence variant in LAMA1, had muscle weakness, myopia, and facial tics
LAMA1 SNP rs2089760 plays an important role in the development of PM.
LAMA1 deficiency can lead to alteration in cytoskeletal dynamics, which may invariably lead to alteration in dendrite growth and axonal formation. Patient-derived fibroblasts have impaired adhesion, reduced migration, abnormal morphology and increased apoptosis due to impaired activation of Cdc42 (show CDC42 Antibodies), a member of the Rho family of GTPases that is involved in cytoskeletal dynamics.
Sixteen novel LAMA1 variants were identified in fourteen families with Poretti-Boltshauser syndrome. The frameshift variant c.[2935delA] recurred in six unrelated families on a shared haplotype, suggesting a founder effect.
Taken together, these findings suggest that miR (show MLXIP Antibodies)-202 may function as a novel tumor suppressor in ESCC by repressing cell proliferation and migration, and its biological effects may attribute the inhibition of LAMA1-mediated FAK (show PTK2 Antibodies)-PI3K (show PIK3CA Antibodies)-Akt (show AKT1 Antibodies) signaling.
Our results indicate that invasion of cervical cancer is accomplished by the remodeling of the interstitial stroma, which process includes decrease and partial replacement of fibronectin (show FN1 Antibodies) and collagens by a laminin-rich matrix
Novel PMCA3 missense mutation co-occurring with a heterozygous mutation in LAMA1 impaired cellular Ca2+ homeostasis in patients with Cerebellar Ataxia.
Identification of biallelic mutations in LAMA1 as the cause of cerebellar dysplasia with cysts in seven affected individuals.
Studies indicate that progenitor endothelial cells (ECs), endothelial colony-forming cells (ECFCs), deposit collagen IV (show COL4 Antibodies), fibronectin (show FN1 Antibodies), and laminin.
miR (show MLXIP Antibodies)-9 negatively controls lamin A (show LMNA Antibodies) and progerin expression in neural cells.
Loss of lama1 leads to divergent effects on focal adhesion assembly in a spatiotemporally-specific manner. Laminin is required for multiple steps of optic cup morphogenesis, including optic stalk constriction, invagination, and formation of a spherical lens. In lama1(UW1) mutants, loss of epithelial polarity and altered adhesion lead to defective tissue architecture and formation of a disorganized retina.
Analysis of zebrafish laminin-alpha 1 mutants reveals multiple functions for laminin-alpha 1 in the outgrowth and guidance of central nervous system axons
Laminin alpha 1 is needed for lens development in zebrafish embryos.
The phenotypic and genetic analyses of a recessive, larval lethal zebrafish mutant, bal(a69), characterized by severe eye defects and shortened body axis, is reported.
two guidance cues, TAG-1 (show CNTN2 Antibodies) and laminin-alpha1, influence the behavior of growth cones during axon pathfinding in vivo
tag1 (show CNTN2 Antibodies), lama1 and vangl2 (show VANGL2 Antibodies) participate in a common mechanism that integrates signaling between the FBMN and its environment to regulate migration.
The distribution of laminin and alphaSMA (show ACTA2 Antibodies) in the testis and epididymis might point out to their roles in the male reproduction.
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
, S-laminin subunit alpha
, laminin A chain
, laminin subunit alpha-1
, laminin-1 subunit alpha
, laminin-3 subunit alpha
, laminin, alpha 1
, laminin subunit alpha-1-like