Latrophilin 3 (LPHN3) ELISA Kits

Human Latrophilin 3 (LPHN3) interaction partners

1. Study identified ADGRL3 as a risk gene for substance use disorder.

2. An ultraconserved brain-specific enhancer within LPHN3 is associated with ADHD susceptibility.

3. Associations between LPHN1 and LPHN3 polymorphisms and severity of bronchial hyper-responsiveness in asthmatics were conducted; however, no associations were found.

4. Results suggest that UNC5 and LPHN3 can simultaneously bind to FLRT3, forming a trimeric complex, and that FLRT3 may form transsynaptic complexes with both LPHN3 and UNC5.

5. LPHN3 confers ADHD susceptibility, and moderates methylphenidate treatment response in children and adolescents with ADHD.

6. Study examined the association between the LPHN3 rs6551665 A/G polymorphism and Attention deficit hyperactivity disorder (ADHD) in Korea; samples used in the study consisted of 150 ADHD children and 322 controls; ADHD children appeared to have a surplus of GG genotype, studies with larger sample sizes needed.

7. genetic association studies in Germany: Data suggest that, within a sample of patients with attention deficit disorder hyperactivity, SNPs in LPHN3 gene impacts behavioral and neurophysiological measures of cognitive response control.

8. Increased LPHN3 mRNA expression levels correlated with axillary-node metastasis in breast cancer.

9. The influence of LPHN3 genotype on attention deficit-hyperactivity disorder (ADHD) and addiction is mediated through alterations in transgenic monoamine signaling.

10. A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome.

11. This study identifying loci for aADHD and led to the identification of LPHN3 as novel genes associated with ADHD across the lifespan.

12. highly significant interaction between four SNPs and maternal stress during pregnancy and development of attention-deficit/hyperactivity disorder

13. single-nucleotide polymorphisms harbored in the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 and NCAM1 genes, to double the risk of developing ADHD.

14. This study demonistrated that LPHN3 and its ligand FLRT3 play an important role in glutamatergic synapse development.

15. LPHN3, a new gene in which variants have recently been shown to be associated with adhd.

16. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder

17. The mutational analysis of the entire coding region of LPHN3 in a cohort of 139 attention deficit hyperactivity disorder subjects and 52 controls, is reported.

Mouse (Murine) Latrophilin 3 (LPHN3) interaction partners

1. Data show that Unc5 cell guidance receptor Unc5D controls Latrophilin3 (LPHN3)-FLRT protein FLRT2-mediated cell adhesion.

2. The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues.

3. Null mutant Lphn3 mice had a hyperactive phenotype in the open field test, independent of sex, and were more sensitive to locomotor stimulation.