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LGALS12 encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. Additionally we are shipping LGALS12 Kits (36) and LGALS12 Proteins (9) and many more products for this protein.
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The activation of STAT3 was much higher in Gal12(-/-) macrophages activated by lipopolysaccharide, which was correlated with higher levels of IL-10. Adipocytes showed higher insulin sensitivity when treated with Gal12(-/-) macrophage-conditioned media than those treated with Gal12(+/+) macrophages.
galectin 12 has a role in mitochondrial respiration, adiposity, and insulin resistance/glucose intolerance
Results suggest that galectin-12 is required for signal transduction that conveys hormone stimulation to the induction of adipogenic factors essential for adipocyte differentiation.
Galectin-12 is silenced in colorectal cancer via hypermethylation of its promoter.
Overexpression of galectin-12 contributes to a differentiation block in acute promyelocytic leukemia cells, and suppression of galectin-12 facilitates granulocytic differentiation.
Lower LGALS12 gene expression is associated with acute myeloid leukemia.
results suggest that mouse galectin-12 is a major regulator of adipose tissue development
This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described.
lectin, galactoside-binding, soluble, 12
, lectin, galactoside-binding, soluble, 12 (galectin 12)
, galectin-related inhibitor of proliferation 1
, lectin, galactose binding, soluble 12
, galectin 12
, galectin-related inhibitor of proliferation