anti-Lectin, Galactoside-Binding, Soluble, 8 (LGALS8) Antibodies

LGALS8 encodes a member of the galectin family. Additionally we are shipping Lectin, Galactoside-Binding, Soluble, 8 Kits (58) and Lectin, Galactoside-Binding, Soluble, 8 Proteins (29) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LGALS8 56048 Q9JL15
LGALS8 3964 O00214
LGALS8 116641  
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Top anti-Lectin, Galactoside-Binding, Soluble, 8 Antibodies at antibodies-online.com

Showing 10 out of 141 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LGALS8 Antibody Titration: 0.2-1 ug/mlPositive Control: Hela cell lysate 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated WB 100 μg 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Galectin 8 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Galectin 8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using LEG8 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using LEG8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB LGALS8 Antibody (C-term)  western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the LGALS8 antibody detected the LGALS8 protein (arrow). Anti-LGALS8 Antibody (C-term)at 1:2000 dilution + LNCaP whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 36 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: Non-transfected 293T lysates B: LGALS8 transfected 293T lysates 10% SDS PAGE antibody diluted at 1:5000 100 μL 3 to 4 Days
$380.38
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-LGALS8 / Galectin-8 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959345 concentration 5 ug/ml. Anti-LGALS8 / Galectin-8 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959345 concentration 5 ug/ml. 50 μL 11 to 14 Days
$484.00
Details
Chicken Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using LGALS8 antibody (ABIN5973999) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human colon carcinoma using LGALS8 antibody (ABIN5973999) at dilution of 1/100 (40x lens). 100 μL 11 to 16 Days
$426.40
Details

Top referenced anti-Lectin, Galactoside-Binding, Soluble, 8 Antibodies

  1. Human Monoclonal LGALS8 Primary Antibody for Func, IA - ABIN2192096 : Levy, Arbel-Goren, Hadari, Eshhar, Ronen, Elhanany, Geiger, Zick: Galectin-8 functions as a matricellular modulator of cell adhesion. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Lectin, Galactoside-Binding, Soluble, 8 Interaction Partners

Mouse (Murine) Lectin, Galactoside-Binding, Soluble, 8 (LGALS8) interaction partners

  1. these findings identify gal-8 as a new physiologic player in the regulation of bone mass.

  2. Galectin-8 regulates antibacterial autophagy through differential recognition of host glycans on damaged phagosomes.

  3. Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation.

  4. these data suggest that Gal-8 promotes the differentiation of highly suppressive Treg cells, which has implications for the treatment of inflammatory and autoimmune diseases.

  5. this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C, podoplanin and integrin pathways plays a key role.

  6. Gal-8mut was unable to induce T-cell proliferation, but efficiently co-stimulated antigen-specific responses, bothin vitroandin vivo.

  7. Gal-8 emerges as an attractive therapeutic candidate.

  8. Galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice.

  9. Gal-8 stimulated naive T cells, but had an antiproliferative effect when these cells were activated.A dose of recombinant Gal-8 administered with a suboptimal Ag dose to DO11.10 mice strengthened weak responses in vivo.

  10. a novel role for Gal-8 in collaboration with Gal-1 in plasma cell formation, and suggest the possibility of using distinct LacNAc ligands to modulate the function of Gals.

  11. The findings of the present study delineate the differential molecular requirements for Gal-8 activities on T-cells, and suggest a dual activity relying on activation state.

  12. galectin-8 is expressed in the thymus in mouse, which suggests an active role for this lectin in shaping the mature T cell repertoire

  13. Taken together, our findings support a distinctive role for locally produced Gal-8 as an enhancer of otherwise borderline immune responses and also suggest that Gal-8 might fuel the reactivity at inflammatory foci.

Human Lectin, Galactoside-Binding, Soluble, 8 (LGALS8) interaction partners

  1. The study identified Gal-8 as a potent factor in osteoarthritis pathogenesis, acting in concert with Gal-1 and -3.

  2. Inhibition of galectin-8- and NDP52-dependent autophagy increased seeded tau aggregation.

  3. analysis of crystallographic structures of the galectin-8 N-terminal domain (galectin-8N) in complex with LNT and LNnT

  4. Gal-8 served as a new positive prognostic factor for the OS and DFS of ovarian cancer patients.

  5. We further demonstrated using the NMR-based hydrogen-deuterium exchange (HDX) that lactose binding increases the exchange rates of residues located on the opposite side of the ligand-binding pocket for hGal1 and hGal8(NTD), indicative of allostery. Additionally, lactose binding induces significant stabilisation of hGal8(CTD) across the entire domain

  6. findings reveal that differential levels of Gal-3 and Gal-8 expression and recruitment to Group A streptococcus (GAS) between epithelial cells and endothelial cells may contribute to the different outcomes of GAS elimination or survival and growth of GAS in these two types of cells.

  7. the natural and conserved expression of Gal-8 in tumour cells is responsible for the metastatic evolution of prostate cancer.

  8. Both Gal-8 isoforms led to enhanced adhesion of myeloma cells to vascular endothelium under dynamic shear stress conditions, Gal-8L (by more than 40-fold) even stronger than Gal-8S.

  9. Our data indicate that Gal-8 interacts with ALCAM at the surface of breast cancer cells through glycosylation-dependent mechanisms. A novel heterophilic interaction between ALCAM and Gal-8 is demonstrated here, suggesting its physiologic relevance in the biology of breast cancer cells

  10. we detected Gal-8 in human cerebrospinal fluid, suggesting a role in the CNS immune-surveillance circuit. In addition, we show that MS patients generate function-blocking anti-Gal-8 antibodies with pathogenic potential. Furthermore, circulating anti-Gal-8 antibodies associate with relapsing-remitting MS, and not with progressive MS phenotypes, predicting clinical disability at diagnosis within the first year of follow-up

  11. Data suggest that galectin-8 is a potential independent favorable prognostic biomarker for survival and recurrence of patients with gastric cancer after surgery.

  12. this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C, podoplanin and integrin pathways plays a key role.

  13. Platelet-derived factor V/Va is generated following endocytosis of the plasma-derived molecule by the platelet precursor cells, megakaryocytes, via a two receptor system consisting of LRP-1 and an unidentified specific "binding site".

  14. Gal-8 expression is a potential independent unfavorable prognostic indicator for postoperative recurrence of patients with localized pT1 clear cell renal cell carcinoma

  15. The fundamental roles of galectin-8 in human anaplastic large cell lymphoma

  16. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis

  17. We integrate here the available information on Gal-8 expression in different tumor types and attempt to elucidate associations of its expression and localization with tumor progression[review]

  18. these results not only confirm the pro-inflammatory role we have already proposed for Gal-8 in other cellular systems but also suggest that this lectin is orchestrating the interaction between leukocytes, platelets and endothelial cells

  19. Whereas Galectin (Gal)-1, -3, and -8 triggered vascular endothelial growth factor (VEGF) release, only Gal-8 induced endostatin secretion.

  20. Focusing on the F19Y change in galectin-8, we study of consequences of a single-site substitution in the carbohydrate recognition domain of this family of cellular effectors.

Lectin, Galactoside-Binding, Soluble, 8 (LGALS8) Antigen Profile

Protein Summary

This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with LGALS8

  • galectin 8 (LGALS8) antibody
  • lectin, galactose binding, soluble 8 (Lgals8) antibody
  • galectin 8 (Lgals8) antibody
  • lectin, galactoside binding soluble 8 S homeolog (lgals8.S) antibody
  • 1200015E08Rik antibody
  • AI326142 antibody
  • D13Ertd524e antibody
  • Gal-8 antibody
  • galectin-8 antibody
  • Lgals-8 antibody
  • LGALS8 antibody
  • PCTA-1 antibody
  • PCTA1 antibody
  • Po66-CBP antibody
  • xgalectin-VIIIa antibody

Protein level used designations for LGALS8

lectin, galactoside-binding, soluble, 8 , lectin, galactoside-binding, soluble, 8 (galectin 8) , galectin-8-like , gal-8 , galectin 8 , galectin-8 , galectin-8L , lectin, galactose binding, soluble 5 , galectin-8 variant II , Po66 carbohydrate binding protein , galectin-8g , po66 carbohydrate-binding protein , prostate carcinoma tumor antigen 1 , 30 kDa S-type lectin , RL-30 , lectin, galactose binding, soluble 8 , galectin family xgalectin-VIIIa , xgalectin-VIII

GENE ID SPECIES
710375 Macaca mulatta
743841 Pan troglodytes
100436942 Pongo abelii
100595058 Nomascus leucogenys
56048 Mus musculus
430948 Gallus gallus
3964 Homo sapiens
479193 Canis lupus familiaris
100156193 Sus scrofa
506977 Bos taurus
116641 Rattus norvegicus
100343919 Oryctolagus cuniculus
100733991 Cavia porcellus
101115850 Ovis aries
398442 Xenopus laevis
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