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anti-Lectin, Galactoside-Binding, Soluble, 8 (LGALS8) Antibodies

LGALS8 encodes a member of the galectin family.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse LGALS8 LGALS8 56048 Q9JL15
Anti-Human LGALS8 LGALS8 3964 O00214
Anti-Rat LGALS8 LGALS8 116641  
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Top anti-Lectin, Galactoside-Binding, Soluble, 8 Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-LGALS8 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Galectin 8 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Galectin 8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using LEG8 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using LEG8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged LGALS8 is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: Non-transfected 293T lysates B: LGALS8 transfected 293T lysates 10% SDS PAGE antibody diluted at 1:5000 100 μL Log in to see 1 to 2 Days
$292.60
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-LGALS8 / Galectin-8 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ABIN959345 concentration 5 ug/ml. Anti-LGALS8 / Galectin-8 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ABIN959345 concentration 5 ug/ml. 50 μL Log in to see 7 to 9 Days
$484.00
Details
Chicken Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB LGALS8 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the LGALS8 antibody detected the LGALS8 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 11 to 13 Days
$582.67
Details

Top referenced anti-Lectin, Galactoside-Binding, Soluble, 8 Antibodies

  1. Human Monoclonal LGALS8 Primary Antibody for Func, IA - ABIN2192096 : Levy, Arbel-Goren, Hadari, Eshhar, Ronen, Elhanany, Geiger, Zick: Galectin-8 functions as a matricellular modulator of cell adhesion. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Lectin, Galactoside-Binding, Soluble, 8 Interaction Partners

Mouse (Murine) Lectin, Galactoside-Binding, Soluble, 8 (LGALS8) interaction partners

  1. Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation.

  2. these data suggest that Gal-8 promotes the differentiation of highly suppressive Treg cells, which has implications for the treatment of inflammatory and autoimmune diseases.

  3. this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C (show VEGFC Antibodies), podoplanin (show PDPN Antibodies) and integrin pathways plays a key role.

  4. Gal (show GAL Antibodies)-8mut was unable to induce T-cell proliferation, but efficiently co-stimulated antigen-specific responses, bothin vitroandin vivo.

  5. Gal-8 emerges as an attractive therapeutic candidate.

  6. Galectin-8 induces RANKL (show TNFSF11 Antibodies) expression, osteoclastogenesis, and bone mass reduction in mice.

  7. Gal-8 stimulated naive T cells, but had an antiproliferative effect when these cells were activated.A dose of recombinant Gal-8 administered with a suboptimal Ag dose to DO11.10 mice strengthened weak responses in vivo.

  8. a novel role for Gal-8 in collaboration with Gal-1 (show LGALS1 Antibodies) in plasma cell formation, and suggest the possibility of using distinct LacNAc ligands to modulate the function of Gals.

  9. The findings of the present study delineate the differential molecular requirements for Gal-8 activities on T-cells, and suggest a dual activity relying on activation state.

  10. galectin-8 is expressed in the thymus in mouse, which suggests an active role for this lectin in shaping the mature T cell repertoire

Human Lectin, Galactoside-Binding, Soluble, 8 (LGALS8) interaction partners

  1. We further demonstrated using the NMR-based hydrogen-deuterium exchange (HDX) that lactose binding increases the exchange rates of residues located on the opposite side of the ligand-binding pocket for hGal1 and hGal8(NTD), indicative of allostery. Additionally, lactose binding induces significant stabilisation of hGal8(CTD) across the entire domain

  2. findings reveal that differential levels of Gal-3 and Gal-8 expression and recruitment to Group A streptococcus (GAS) between epithelial cells and endothelial cells may contribute to the different outcomes of GAS elimination or survival and growth of GAS in these two types of cells.

  3. the natural and conserved expression of Gal-8 in tumour cells is responsible for the metastatic evolution of prostate cancer.

  4. Both Gal-8 isoforms led to enhanced adhesion of myeloma cells to vascular endothelium under dynamic shear stress conditions, Gal (show GAL Antibodies)-8L (by more than 40-fold) even stronger than Gal (show GAL Antibodies)-8S.

  5. Our data indicate that Gal-8 interacts with ALCAM at the surface of breast cancer cells through glycosylation-dependent mechanisms. A novel heterophilic interaction between ALCAM and Gal-8 is demonstrated here, suggesting its physiologic relevance in the biology of breast cancer cells

  6. we detected Gal-8 in human cerebrospinal fluid, suggesting a role in the CNS immune-surveillance circuit. In addition, we show that MS patients generate function-blocking anti-Gal-8 antibodies with pathogenic potential. Furthermore, circulating anti-Gal-8 antibodies associate with relapsing-remitting MS, and not with progressive MS phenotypes, predicting clinical disability at diagnosis within the first year of follow-up

  7. Data suggest that galectin-8 is a potential independent favorable prognostic biomarker for survival and recurrence of patients with gastric cancer after surgery.

  8. this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C (show VEGFC Antibodies), podoplanin (show PDPN Antibodies) and integrin pathways plays a key role.

  9. Platelet-derived factor V/Va is generated following endocytosis of the plasma-derived molecule by the platelet precursor cells, megakaryocytes, via a two receptor system consisting of LRP-1 (show LRP1 Antibodies) and an unidentified specific "binding site".

  10. Gal-8 expression is a potential independent unfavorable prognostic indicator for postoperative recurrence of patients with localized pT1 (show ZNF77 Antibodies) clear cell renal cell carcinoma (show MOK Antibodies)

Lectin, Galactoside-Binding, Soluble, 8 (LGALS8) Antigen Profile

Protein Summary

This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with LGALS8

  • galectin 8 (LGALS8) antibody
  • lectin, galactose binding, soluble 8 (Lgals8) antibody
  • galectin 8 (Lgals8) antibody
  • lectin, galactoside binding soluble 8 S homeolog (lgals8.S) antibody
  • 1200015E08Rik antibody
  • AI326142 antibody
  • D13Ertd524e antibody
  • Gal-8 antibody
  • galectin-8 antibody
  • Lgals-8 antibody
  • LGALS8 antibody
  • PCTA-1 antibody
  • PCTA1 antibody
  • Po66-CBP antibody
  • xgalectin-VIIIa antibody

Protein level used designations for LGALS8

lectin, galactoside-binding, soluble, 8 , lectin, galactoside-binding, soluble, 8 (galectin 8) , galectin-8-like , gal-8 , galectin 8 , galectin-8 , galectin-8L , lectin, galactose binding, soluble 5 , galectin-8 variant II , Po66 carbohydrate binding protein , galectin-8g , po66 carbohydrate-binding protein , prostate carcinoma tumor antigen 1 , 30 kDa S-type lectin , RL-30 , lectin, galactose binding, soluble 8 , galectin family xgalectin-VIIIa , xgalectin-VIII

GENE ID SPECIES
710375 Macaca mulatta
743841 Pan troglodytes
100436942 Pongo abelii
100595058 Nomascus leucogenys
56048 Mus musculus
430948 Gallus gallus
3964 Homo sapiens
479193 Canis lupus familiaris
100156193 Sus scrofa
506977 Bos taurus
116641 Rattus norvegicus
100343919 Oryctolagus cuniculus
100733991 Cavia porcellus
101115850 Ovis aries
398442 Xenopus laevis
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