-
A cell that experiences the highest level of Nodal signaling begins to express Lefty1 and becomes an L1(epi) cell. Deletion of Lefty1 alone or together with Lefty2 increased the number of prospective DVE cells
-
Lefty1 may ameliorate renal tubulointerstitial inflammation by suppressing NFkappaB signaling.
-
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A and DNMT3B; findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation and demethylation crucial to regulation of key signalling pathways in early body plan formation
-
exogenous lefty1 administered to mice restored the endogenous expression levels of lefty1. The present study demonstrated that lefty1 attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 signaling pathway
-
Lefty-1 may prevent TGFB1-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3, JNK-3, and BMP-5 signaling.
-
The expression of lefty in RCC cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC.
-
Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.
-
Taken together, these results suggest that optimal expression of Lefty1 and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.
-
Beta-catenin can recruit the H3K4me2/1 demethylase LSD1 to regulate the expression of the tumor suppressor Lefty1 in mouse embryonic stem cells.
-
Lefty can antagonise TGF-beta1 mediated epithelial-mesenchymal transition in renal tubular epithelial cells.
-
modulates both the induction of decidual differentiation and the maintenance of a decidualized state by an autocrine mechanism
-
Cerberus-like and Lefty-1 function redundantly to modulate Nodal signaling during gastrulation and regulate patterning of the primitive streak
-
Regulated expression and spatial distribution of lefty in mouse endometrium confines its biological impact on tissues that undergo remodelling during estrous cycle and pregnancy.
-
findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty by PC5/6A
-
The gene for Lefty1 protein, a Nodal antagonist that influences the direction of DVE migration, was found to be asymmetrically expressed in the primitive endoderm of the implanting blastocyst.
-
after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9.
-
Data suggest that Nodal and lefty signaling regulates the growth of pancreatic cells.