More product categories related to LRSAM1 ELISA Kit
More ELISA Kits for LRSAM1 Interaction Partners
Human Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners
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We report a novel LRSAM1 mutation c.2021-2024del (p.E674VfsX11) in 4 members of a Chinese autosomal dominant Charcot-Marie-Tooth disease type 2 family
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The article systematically represents the molecular functions, nature and detailed characterization of LRSAM1 E3 ubiquitin ligase, which are linked to molecular mechanisms of neurodegeneration. (Review)
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Our study shows the potential function of mir-939 through regulating LRSAM1 in Hirschsprung's disease
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We identified a novel LRSAM1 missense mutation (c.2120C > T, p.Pro707Leu) mapping to the RING domain. The identified missense mutation, as well as of another recently reported pathogenic missense mutation (c.2081G > A, p.Cys694Tyr), revealed that in vitro ubiquitylation activity was largely abrogated.
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findings suggest that the mutant LRSAM1 may aberrantly affect the formation of transcription machinery.
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findings demonstrate that the isolated genetic entity Charcot-Marie-Tooth type 2G is caused by a missense mutation in LRSAM1.
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LRSAM1 exhibited self-association in vitro and in vivo. The study found the self-association of LRSAM1 promotes intermolecular ubiquitination and proved a potential N-terminal ubiquitination.
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Plant homeodomain finger protein 23 negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1
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disruption of the C-terminal RING domain confers dominant negative properties to LRSAM1
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Our data further confirms that LRSAM1 mutations are associated with CMT2 of AD inheritance.
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Authors identify LRSAM1 as the E3 ligase responsible for anti-Salmonella autophagy-associated ubiquitination.
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homozygous mutation in LRSAM1 was proposed as a strong candidate for the disease in a family with recessive axonal polyneuropathy
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LRSAM1 as a component of the antibacterial autophagic response.
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LRSAM1 is a strong candidate for the causal gene for the Charcot-Marie-Tooth disease.
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Results suggest that RIFLE represents a novel signaling protein that mediates components of the Wnt/wingless signaling pathway and cell adhesion in PC12 cells [RIFLE protein].
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Tal regulates a Tsg101-associated complex responsible for the sorting of cargo into cytoplasm-containing vesicles that bud at the multivesicular body and at the plasma membrane
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Tal polyubiquitinates lysine residues in the C-terminus of uncomplexed Tsg101, resulting in proteasomal degradation.
Mouse (Murine) Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners
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downregulation of miR-431-5p promoted proliferation of enteric neural crest cells via targeting LRSAM1, which provides an innovative and candidate target for treatment of Hirschsprung's disease
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TLR4/NF-kappaB-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury.
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Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised.
LRSAM1 Antigen Profile
Antigen Summary
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene.
Gene names and symbols associated with LRSAM1
- leucine rich repeat and sterile alpha motif containing 1 (LRSAM1) antibody
- leucine rich repeat and sterile alpha motif containing 1 (Lrsam1) antibody
- CMT2P antibody
- RIFLE antibody
- TAL antibody
Protein level used designations for LRSAM1
E3 ubiquitin-protein ligase LRSAM1 , Tsg101-associated ligase , leucine-rich repeat and sterile alpha motif-containing protein 1 , tsg101-associated ligase
GENE ID | SPECIES |
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90678 | Homo sapiens |
227738 | Mus musculus |
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