anti-Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) Antibodies

LETM1 encodes a protein that is localized to the inner mitochondrial membrane. Additionally we are shipping LETM1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LETM1 3954 O95202
LETM1 56384 Q9Z2I0
LETM1 305457 Q5XIN6
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Top anti-LETM1 Antibodies at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, IHC, IP, WB Immunofluorescence of monoclonal antibody to LETM1 on HeLa cell (antibody concentration 10 µg/mL). LETM1 monoclonal antibody (M03), clone 6F7 Western Blot analysis of LETM1 expression in HeLa. 100 μg Log in to see 8 to 11 Days
$461.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LETM1 Antibody Titration:  5.0ug/ml  Positive Control:  Jurkat cell lysate LETM1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to LETM1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to LETM1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Western Blot: LETM1 Antibody [NBP1-33433] - A431 lysates (Lane A), H1299 lysates (Lane B), Hela cells (Lane C) and Hep G2 lysates (Lane D) using NBP1-33433 at a dilution of 1:1000. Immunohistochemistry-Paraffin: LETM1 Antibody [NBP1-33433] - Paraffin-embedded HSC3 xenograft, using antibody at 1:500 dilution. 100 μL Log in to see 7 to 9 Days
$514.63
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), IP, WB 100 μg Log in to see 7 to 9 Days
$537.17
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Immunocytochemistry/Immunofluorescence: LETM1 Antibody [NBP1-89556] - Staining of human cell line U-251MG shows positivity in mitochondria. Simple Western: LETM1 Antibody [NBP1-89556] - Simple Western lane view shows a specific band for LETM1 in 0.2 mg/ml of RT-4 (Left) and U-251MG (Right) lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  LETM1  Sample Type:  MDA-MB-435s Whole Cell lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IP, WB LETM1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LETM1 expression in mouse kidney. LETM1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LETM1 expression in A-431. 100 μL Log in to see 11 to 12 Days
$425.71
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of Ramos cells, using LETM1 antibody. ABIN6273261 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-LETM1 Antibodies

  1. Human Monoclonal LETM1 Primary Antibody for IF, IHC (p) - ABIN561659 : Dimmer, Navoni, Casarin, Trevisson, Endele, Winterpacht, Salviati, Scorrano: LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability. in Human molecular genetics 2008 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal LETM1 Primary Antibody for ELISA, WB - ABIN517469 : Mallilankaraman, Cárdenas, Doonan, Chandramoorthy, Irrinki, Golenár, Csordás, Madireddi, Yang, Müller, Miller, Kolesar, Molgó, Kaufman, Hajnóczky, Foskett, Madesh: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. in Nature cell biology 2012 (PubMed)

  3. Human Polyclonal LETM1 Primary Antibody for ICC, IF - ABIN4330704 : Kuum, Veksler, Liiv, Ventura-Clapier, Kaasik: Endoplasmic reticulum potassium-hydrogen exchanger and small conductance calcium-activated potassium channel activities are essential for ER calcium uptake in neurons and cardiomyocytes. in Journal of cell science 2012 (PubMed)

More Antibodies against LETM1 Interaction Partners

Human Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) interaction partners

  1. these results revealed that the knockdown of LETM1 exhibited tumor suppressive effects, possibly by controlling the downstream Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.

  2. Data indicate a positive association between LETM1 up-regulation, YAP1 nuclear localization and high PDGFB expression.

  3. LETM1 plays an important role in the progression of breast cancer

  4. LETM1 protein overexpression is associated with Triple negative breast cancer progression, and may be a potential biomarker for poor prognostic evaluation of Triple negative breast cancer.

  5. LETM1 plays an important role in the progression of head and neck squamous cell carcinoma.

  6. Letm1 expression is decreased in patients with intractable TLE and a rat model of epilepsy. Down-regulation of Letm1 leads to increases mitochondrial swelling and decreased MT-CYB (show MT-CYB Antibodies) expression, which is associated with susceptibility to seizures.

  7. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2 (show CA2 Antibodies)+) transport and bioenergetics

  8. These findings identify novel cellular phenotypes in Wolf-Hirschhorn syndrome attributable to a 50% reduction in LETM1 expression level.

  9. Haploinsufficiency of WHSC1 (show WHSC1 Antibodies) and/or LETM1 contributes to Wolf-Hirschhorn Syndrome, but that loss of distinct and/or additional genes in 4p16.3 is necessary for the expression of the core Wolf-Hirschhorn Syndrome phenotype.

  10. NCLX (show SLC24A6 Antibodies), but not LETM1, mediates Ca(2 (show CA2 Antibodies)+) extrusion from mitochondria. By controlling the duration of matrix Ca(2 (show CA2 Antibodies)+) elevations, NCLX (show SLC24A6 Antibodies) contributes to the regulation of NAD(P)H (show NQO1 Antibodies) production and to the conversion of Ca(2 (show CA2 Antibodies)+) signals into redox changes.

Mouse (Murine) Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) interaction partners

  1. This paper's findings delineate a mechanism by which PINK1 (show PINK1 Antibodies) regulates mitochondrial Ca(2 (show CA2 Antibodies)+) level through LETM1 and suggest a model by which PINK1 (show PINK1 Antibodies) loss leads to deficient phosphorylation of LETM1 and impaired mitochondrial Ca(2 (show CA2 Antibodies)+) transport.

  2. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2 (show CA2 Antibodies)+) transport and bioenergetics

  3. Data indicate that cellular Letm1 knockdown reduced Ca(2 (show CA2 Antibodies)+)mito uptake, H(+)mito extrusion and impaired mitochondrial ATP generation capacity.

LETM1 Antigen Profile

Protein Summary

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.

Gene names and symbols associated with LETM1

  • leucine zipper and EF-hand containing transmembrane protein 1 (LETM1) antibody
  • leucine zipper-EF-hand containing transmembrane protein 1 (letm1) antibody
  • leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) antibody
  • LETM1 and EF-hand domain-containing protein 1, mitochondrial (LOC100346816) antibody
  • leucine zipper-EF-hand containing transmembrane protein 1 (Letm1) antibody
  • leucine zipper and EF-hand containing transmembrane protein 1 (Letm1) antibody
  • letm1 antibody
  • MGC145623 antibody
  • wu:fc31h08 antibody
  • wu:fc58h01 antibody
  • zgc:109969 antibody

Protein level used designations for LETM1

leucine zipper-EF-hand containing transmembrane protein 1 , LETM1 and EF-hand domain-containing protein 1, mitochondrial , fc31h08 , fc58h01 , let-m1 , leucine zipper-EF-hand-containing transmembrane protein 1 , Leucine zipper-EF-hand-containing transmembrane protein 1 , LETM1 and EF-hand domain-containing protein 1, mitochondrial-like , Mdm38 homolog

GENE ID SPECIES
461068 Pan troglodytes
570745 Danio rerio
780254 Xenopus (Silurana) tropicalis
100052731 Equus caballus
100346816 Oryctolagus cuniculus
100408245 Callithrix jacchus
100433508 Pongo abelii
100586576 Nomascus leucogenys
422898 Gallus gallus
3954 Homo sapiens
488807 Canis lupus familiaris
513324 Bos taurus
56384 Mus musculus
305457 Rattus norvegicus
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