anti-Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) Antibodies

LETM1 encodes a protein that is localized to the inner mitochondrial membrane. Additionally we are shipping LETM1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LETM1 3954 O95202
LETM1 56384 Q9Z2I0
LETM1 305457 Q5XIN6
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Top anti-LETM1 Antibodies at antibodies-online.com

Showing 10 out of 72 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LETM1 Antibody Titration:  5.0ug/ml  Positive Control:  Jurkat cell lysate LETM1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to LETM1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to LETM1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), IP, WB 100 μg Log in to see 11 to 14 Days
$537.17
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  LETM1  Sample Type:  MDA-MB-435s Whole Cell lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IP, WB LETM1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LETM1 expression in mouse kidney. LETM1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LETM1 expression in A-431. 100 μL Log in to see 11 to 12 Days
$425.71
Details
Bat Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of Ramos cells, using LETM1 antibody. ABIN6273261 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: A431 , B: H1299 C: Hela D: Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated WB LETM1 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the LETM1 antibody detected the LETM1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated IF, ELISA, WB LETM1 monoclonal antibody (M02), clone 2C6. Western Blot analysis of LETM1 expression in HeLa. Detection limit for recombinant GST tagged LETM1 is 0.03 ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$440.00
Details

Top referenced anti-LETM1 Antibodies

  1. Human Monoclonal LETM1 Primary Antibody for IF, IHC (p) - ABIN561659 : Dimmer, Navoni, Casarin, Trevisson, Endele, Winterpacht, Salviati, Scorrano: LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability. in Human molecular genetics 2008 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal LETM1 Primary Antibody for ELISA, WB - ABIN517469 : Mallilankaraman, Cárdenas, Doonan, Chandramoorthy, Irrinki, Golenár, Csordás, Madireddi, Yang, Müller, Miller, Kolesar, Molgó, Kaufman, Hajnóczky, Foskett, Madesh: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. in Nature cell biology 2012 (PubMed)

  3. Human Polyclonal LETM1 Primary Antibody for ICC, IF - ABIN4330704 : Kuum, Veksler, Liiv, Ventura-Clapier, Kaasik: Endoplasmic reticulum potassium-hydrogen exchanger and small conductance calcium-activated potassium channel activities are essential for ER calcium uptake in neurons and cardiomyocytes. in Journal of cell science 2012 (PubMed)

More Antibodies against LETM1 Interaction Partners

Human Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) interaction partners

  1. Here, the authors show that LETM1 is associated with mitochondrial ribosomes, is required for mitochondrial DNA distribution and expression, and regulates the activity of an ancillary metabolic enzyme, pyruvate dehydrogenase.

  2. Data show that LETM1 is a transporter protein localized to the inner mitochondrial membrane shown to have a Ca(2+)/H exchanger activity. The role of LETM1 to Ca(2+) regulation is evident from Wolf-Hirschhorn syndrome patients that harbor a haploinsuficiency in LETM1 expression, leading to dysfunctional mitochondrial Ca(2+) handling and from many types of cancer cells that show an upregulation of its expression. [review]

  3. these results revealed that the knockdown of LETM1 exhibited tumor suppressive effects, possibly by controlling the downstream Wnt/beta-catenin signaling pathway.

  4. Data indicate a positive association between LETM1 up-regulation, YAP1 nuclear localization and high PDGFB expression.

  5. LETM1 plays an important role in the progression of breast cancer

  6. LETM1 protein overexpression is associated with Triple negative breast cancer progression, and may be a potential biomarker for poor prognostic evaluation of Triple negative breast cancer.

  7. LETM1 plays an important role in the progression of head and neck squamous cell carcinoma.

  8. Letm1 expression is decreased in patients with intractable TLE and a rat model of epilepsy. Down-regulation of Letm1 leads to increases mitochondrial swelling and decreased MT-CYB expression, which is associated with susceptibility to seizures.

  9. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics

  10. These findings identify novel cellular phenotypes in Wolf-Hirschhorn syndrome attributable to a 50% reduction in LETM1 expression level.

  11. Haploinsufficiency of WHSC1 and/or LETM1 contributes to Wolf-Hirschhorn Syndrome, but that loss of distinct and/or additional genes in 4p16.3 is necessary for the expression of the core Wolf-Hirschhorn Syndrome phenotype.

  12. NCLX, but not LETM1, mediates Ca(2+) extrusion from mitochondria. By controlling the duration of matrix Ca(2+) elevations, NCLX contributes to the regulation of NAD(P)H production and to the conversion of Ca(2+) signals into redox changes.

  13. Functional properties of Letm1 described in study are remarkably similar to those of the H(+)-dependent Ca(2+) transport mechanism identified in intact mitochondria.

  14. Data indicate that loss of Letm1 contributes to the pathology of Wolf-Hirschhorn syndrome and may contribute to seizure phenotypes by reducing glucose oxidation and other specific metabolic alterations.

  15. Summarizes the current state of the art about the functions of LETM1 and its role in pathophysiology, with some emphasis on whether it is a feasible candidate for regulation of mitochondrial Ca2+ homeostasis.

  16. Letm1 and UCP2/3 independently contribute to two distinct, mitochondrial Ca(2+) uptake pathways in intact endothelial cells.

  17. we have identified a novel submicroscopic duplication involving dosage sensitive genes TACC3, FGFR3, and LETM1.

  18. LETM1 suppressed lung cancer cell growth in vitro and in vivo.

  19. LETM1 is evolutionarily conserved throughout the eukaryotic kingdom and located in the mitochondria.

  20. Here, we present cellular and biochemical analysis of Letm1

Mouse (Murine) Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) interaction partners

  1. This paper's findings delineate a mechanism by which PINK1 regulates mitochondrial Ca(2+) level through LETM1 and suggest a model by which PINK1 loss leads to deficient phosphorylation of LETM1 and impaired mitochondrial Ca(2+) transport.

  2. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics

  3. Data indicate that cellular Letm1 knockdown reduced Ca(2+)mito uptake, H(+)mito extrusion and impaired mitochondrial ATP generation capacity.

LETM1 Antigen Profile

Protein Summary

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.

Gene names and symbols associated with LETM1

  • leucine zipper and EF-hand containing transmembrane protein 1 (LETM1) antibody
  • leucine zipper-EF-hand containing transmembrane protein 1 (letm1) antibody
  • leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) antibody
  • LETM1 and EF-hand domain-containing protein 1, mitochondrial (LOC100346816) antibody
  • leucine zipper-EF-hand containing transmembrane protein 1 (Letm1) antibody
  • leucine zipper and EF-hand containing transmembrane protein 1 (Letm1) antibody
  • letm1 antibody
  • MGC145623 antibody
  • wu:fc31h08 antibody
  • wu:fc58h01 antibody
  • zgc:109969 antibody

Protein level used designations for LETM1

leucine zipper-EF-hand containing transmembrane protein 1 , LETM1 and EF-hand domain-containing protein 1, mitochondrial , fc31h08 , fc58h01 , let-m1 , leucine zipper-EF-hand-containing transmembrane protein 1 , Leucine zipper-EF-hand-containing transmembrane protein 1 , LETM1 and EF-hand domain-containing protein 1, mitochondrial-like , Mdm38 homolog

GENE ID SPECIES
461068 Pan troglodytes
570745 Danio rerio
780254 Xenopus (Silurana) tropicalis
100052731 Equus caballus
100346816 Oryctolagus cuniculus
100408245 Callithrix jacchus
100433508 Pongo abelii
100586576 Nomascus leucogenys
422898 Gallus gallus
3954 Homo sapiens
488807 Canis lupus familiaris
513324 Bos taurus
56384 Mus musculus
305457 Rattus norvegicus
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