LETM1 Products
(Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1))
Categories
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009].
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Featured LETM1 Categories
LETM1 Antibodies
High quality antibodies with extensive validation data.
LETM1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LETM1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, IHC (p), ICC
Validations
- (1)
- (6)
Cat. No.
ABIN2856867
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IP, IHC (p)
Validations
- (6)
- (8)
Cat. No.
ABIN561659
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (4)
Cat. No.
ABIN950010
Quantity
100 μL
Datasheet
Datasheet
Recommended LETM1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309315
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
Cat. No.
ABIN3120389
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN3120390
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our LETM1 products
: "Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency." in: Cell reports, Vol. 23, Issue 13, pp. 3710-3720.e8, (2018) (PubMed).: "High expression of leucine zipper-EF-hand containing transmembrane protein 1 predicts poor prognosis in head and neck squamous cell carcinoma." in: BioMed research international, Vol. 2014, pp. 850316, (2014) (PubMed).
: "LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 11, pp. 4936-49, (2014) (PubMed).
: "LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition." in: Disease models & mechanisms, Vol. 7, Issue 5, pp. 535-45, (2014) (PubMed).
: "Co-delivery of LETM1 and CTMP synergistically inhibits tumor growth in H-ras12V liver cancer model mice." in: Cancer gene therapy, Vol. 20, Issue 3, pp. 186-94, (2013) (PubMed).
: "MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism." in: Nature cell biology, Vol. 14, Issue 12, pp. 1336-43, (2012) (PubMed).
: "Endoplasmic reticulum potassium-hydrogen exchanger and small conductance calcium-activated potassium channel activities are essential for ER calcium uptake in neurons and cardiomyocytes." in: Journal of cell science, Vol. 125, Issue Pt 3, pp. 625-33, (2012) (PubMed).
: "Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis." in: Cellular signalling, Vol. 21, Issue 5, pp. 767-77, (2009) (PubMed).
: "Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death." in: Cancer research, Vol. 69, Issue 8, pp. 3397-404, (2009) (PubMed).
: "LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability." in: Human molecular genetics, Vol. 17, Issue 2, pp. 201-14, (2008) (PubMed).
Synonyms and alternative names related to LETM1
leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), leucine zipper-EF-hand containing transmembrane protein 1 (letm1), leucine zipper-EF-hand containing transmembrane protein 1 (LETM1), LETM1 and EF-hand domain-containing protein 1, mitochondrial (LOC100346816), leucine zipper-EF-hand containing transmembrane protein 1 (Letm1), leucine zipper and EF-hand containing transmembrane protein 1 (Letm1), LETM1, letm1, MGC145623, wu:fc31h08, wu:fc58h01, zgc:109969Protein level used designations for LETM1
- leucine zipper-EF-hand containing transmembrane protein 1
- LETM1 and EF-hand domain-containing protein 1, mitochondrial
- fc31h08
- fc58h01
- let-m1
- leucine zipper-EF-hand-containing transmembrane protein 1
- Leucine zipper-EF-hand-containing transmembrane protein 1
- LETM1 and EF-hand domain-containing protein 1, mitochondrial-like
- Mdm38 homolog
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