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Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Additionally we are shipping Leukotriene A4 Hydrolase Kits (24) and Leukotriene A4 Hydrolase Proteins (14) and many more products for this protein.
Showing 10 out of 93 products:
Bat Polyclonal LTA4H Primary Antibody for WB - ABIN610961
Beckhelling, Chang, Chevalier, Ford, Houliston: Pre-M phase-promoting factor associates with annulate lamellae in Xenopus oocytes and egg extracts. in Molecular biology of the cell 2003
Human Monoclonal LTA4H Primary Antibody for IF, IP - ABIN2452643
Wells, OReilly, Szul, Sullivan, Handley, Garrett, McNicholas, Roda, Miller, Tal-Singer, Gaggar, Rennard, Jackson, Blalock: An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease. in American journal of respiratory and critical care medicine 2014
Human Monoclonal LTA4H Primary Antibody for IP, IHC - ABIN2452494
Tian, Jiang, Tamosiuniene, Sung, Qian, Dhillon, Gera, Farkas, Rabinovitch, Zamanian, Inayathullah, Fridlib, Rajadas, Peters-Golden, Voelkel, Nicolls: Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension. in Science translational medicine 2013
lta4h mutations confer hypersusceptibility to mycobacterial infection by redirecting eicosanoid substrates to anti-inflammatory lipoxins.
Mutating F375 in xlLTA4H to tyrosine abolishes the formation of the LTB4 (show PTGR1 Antibodies) isomeric product Delta(6)-trans-Delta(8)-cis (show CISH Antibodies)-LTB4 (show PTGR1 Antibodies).
A higher incidence of severe IRIS among patients with mutant LTA4H genotypes (CT and TT) was observed compared to the wild type, despite similar IRIS incidence and immune restoration in both groups. Steroids were effective in alleviating IRIS in all the genotypes
The LTA4H promoter polymorphism correlated with CSF (show CSF2 Antibodies) mononuclear cell count but not with mortality in tuberculous meningitis
LTA4H genotype predicted survival of HIV-uninfected patients, with TT-genotype patients significantly more likely to survive tuberculous meningitis than CC-genotype patients. LTA4H genotype and HIV infection influence pretreatment inflammatory phenotype and survival from tuberculous meningitis. LTA4H genotype may predict adjunctive corticosteroid responsiveness in HIV-uninfected individuals.
LTA4H promoter region SNP was associated with susceptibility to bacteriologically confirmed bacterial meningitis but did not influence clinical presentation, disease severity or survival following dexamethasone treatment.
Report no association between LTA4H SNPs and atherosclerotic plaque phenotypes.
The best proteinogenic amino acid recognized by LTA4H is arginine.
The results of our study failed to confirm whether the selected variants in LTA4H gene within the LT metabolism pathway contribute to platelet reactivity in a diabetic population treated with ASA (show ARSA Antibodies).
The LTA4H A-9188>G polymorphism has a strong association with severe asthma in children.
Data indicate that 13S,14S-epoxy-docosahexaenoic acid (DHA) inhibits leukotriene B4 (LTB4 (show PTGR1 Antibodies)) biosynthesis by leukotriene A4 hydrolase (LTA4H).
genetic association studies in population of Han Chinese in Eastern China: Using a recessive genetic model, an SNP in LTA4H (rs6538697) is associated with increased risk of ischemic stroke.
These findings indicate that LTA4H is critical for skin carcinogenesis and is an important mediator of cell cycle and the data begin to clarify the mechanisms of LTA4H's role in cancer development.
There is a critical role for the secondary anti-inflammatory activity of LTA4H in acute pulmonary infection.
CS exposure promotes the development of CS-induced emphysema by suppressing the enzymatic activities of the LTA4H aminopeptidase in lung tissues and accumulating PGP and neutrophils in the airspaces.
in acute neutrophil-driven lung inflammation, PGP was degraded by LTA(4)H which facilitated resolution of inflammation; cigarette smoke, a major risk factor for COPD,inhibited LTA(4)H aminopeptidase activity leading to accumulation of PGP and neutrophils
5-lipoxygenase (show ALOX5 Antibodies) and leukotriene A4 hydrolase expression in atherosclerotic lesions correlates with symptoms of plaque instability
In the mouse nervous system ,Immunoreactivity for leukotriene A4 hydrolase showed widespread distribution with preference to the sensory-associated structures.
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
leukotriene A4 hydrolase
, leukotriene A-4 hydrolase
, Leukotriene A4 hydrolase
, leukotriene A-4 hydrolase-like
, LTA-4 hydrolase
, aminopeptidase T
, leukotriene A(4) hydrolase
, LTA4 hydrodase
, LTA4 hydrolase