anti-Lin-28 Homolog B (C. Elegans) (LIN28B) Antibodies

The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. Additionally we are shipping LIN28B Proteins (8) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LIN28B 389421 Q6ZN17
LIN28B 380669 Q45KJ6
LIN28B 689054  
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Top anti-LIN28B Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of LIN28B Antibody (N-term) (ABIN388295) in HL60 cell line lysates (35 µg/lane). LIN28B (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human Testis tissue reacted with LIN28B Antibody (N-term)(ABIN388295), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of anti-LIN28B Pab (ABIN388297) in K562 cell line lysates (35 µg/lane). LIN28B(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human testis tissue reacted with LIN28B antibody (Center) (ABIN388297), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of LIN28B Antibody (C-term) in HL60 cell line lysates (35 µg/lane). LIN28B (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Flow cytometric analysis of HL-60 cells using LIN28B Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: Lin28B Antibody [NBP1-85438] - Staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells. Immunocytochemistry/Immunofluorescence: Lin28B Antibody [NBP1-85438] Staining of human cell line U-251 MG shows positivity in nucleus but not nucleoli, cytoplasm & mitochondria. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated EIA, WB   0.4 mL Log in to see 8 to 11 Days
$517.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Lin28B Antibody [NBP2-32352] - placenta Immunohistochemistry: Lin28B Antibody [NBP2-32352] - Immunohistochemical staining of human placenta shows weak cytoplasmic positivity in trophoblastic cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated FACS, IF, IHC, ELISA, WB Confocal immunofluorescent analysis of LIN28B antibody and HepG2 cells with Alexa Fluor 488-conjugated secondary (green). DAPI was used to stain the cell nuclear (blue). Flow cytometric analysis of HL-60 cells using LIN28B antibody (green) 0.4 mL Log in to see 2 to 3 Days
$411.13
Details
Human Rabbit Un-conjugated FACS, IF, IHC, WB Western blot analysis of extracts of HEK-293 cells, using LIN28B antibody. 100 μL Log in to see 16 Days
$357.62
Details

Top referenced anti-LIN28B Antibodies

  1. Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388295 : Guo, Chen, Ito, Watanabe, Ge, Kodama, Aburatani: Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. in Gene 2006 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388297 : Mongroo, Noubissi, Cuatrecasas, Kalabis, King, Johnstone, Bowser, Castells, Spiegelman, Rustgi: IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. in Cancer research 2011 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal LIN28B Primary Antibody for FACS, WB - ABIN388296 : Beachy, Onozawa, Chung, Slape, Bilke, Francis, Pineda, Walker, Meltzer, Aplan: Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. in Blood 2012 (PubMed)
    Show all 2 Pubmed References

More Antibodies against LIN28B Interaction Partners

Human Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. downregulation of Lin28b by miR (show MLXIP Antibodies)-125a partially accounts for its antiproliferative activity toward hepatocellular carcinoma cells.

  2. The effects of acetylated Lin28B on let-7a-1 and let-7g are similar to that of stable knockdown of Lin28B in H1299 cells. The new role of PCAF (show KAT2B Antibodies) in mediating Lin28B acetylation and the specific release of its target microRNAs in H1299 cells may shed light on the potential application of let-7 in the clinical treatment of lung cancer patients

  3. High LIN28B is associated with cervical cancer.

  4. Data found that LIN28B expression is inhibited in hepatoma cells by miR (show MLXIP Antibodies)-125b-5p promoting HBV replication.

  5. Studied the association between Lin28 (show LIN28A Antibodies) homolog B (LIN28B) gene polymorphisms and Wilms tumor susceptibility in Chinese children.

  6. C allele frequency in rs314276 of LIN28B is associated with Central precocious puberty.

  7. Testing for a combination of elevated IMP3 (show IGF2BP3 Antibodies) and Lin28B levels could further facilitate the identification of a patient subgroup with the worst ovarian cancer prognosis.

  8. Lin28A (show LIN28A Antibodies) and Lin28B are co-expressed colon cancer tissues and have functional similarities.

  9. LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19 (show NCKAP1 Antibodies).

  10. The study deciphered the essential role of Lin28B in the pathogenesis of epithelial-mesenchymal transition in idiopathic pulmonary fibrosis, and unraveled a novel mechanism that miR (show MLXIP Antibodies)-26a is a modulator of let-7d.

Mouse (Murine) Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. Regulating the IL-1beta (show IL1B Antibodies)/miR (show MLXIP Antibodies)-i101/Lin28B signaling pathway.

  2. The study deciphered the essential role of Lin28B in the pathogenesis of epithelial-mesenchymal transition in idiopathic pulmonary fibrosis, and unraveled a novel mechanism that miR (show MLXIP Antibodies)-26a is a modulator of let-7d.

  3. Study generated transgenic mice that either overexpressed Lin28b in Math1 (show ATOH1 Antibodies)-positive cerebellar granule neuron precursors or in a broad range of Nestin (show NES Antibodies)-positive neural precursors; while overexpression of LIN28B in Nestin (show NES Antibodies)-positive cells does not lead to tumor formation, it results in a protracted development of granule cells and inhibitory interneurons and leads to a hypersublobulation of the cerebellar vermis.

  4. this study shows that ectopic Lin28b expression reinitiates fetal regenerative potential in a subset of adult hematopoietic stem cells

  5. expression of the heterochronic factor Lin28b decreases in common myeloid progenitors during hematopoietic maturation to adulthood in mice.

  6. loss of Lin28b expression in fetal T cells leads to increased mature let-7, which causes decreased expression of TGF-betaRI, TGF-betaRIII, and SMAD2 (show SMAD2 Antibodies) proteins. A reduction in TGF-beta (show TGFB1 Antibodies) signaling leads to reduced Treg numbers.

  7. Lin28b positively regulates the expression of Lin28b itself and cell cycle-related proteins in hepatoblasts by suppressing the maturation of target microRNAs, lethal-7b and miR (show MLXIP Antibodies)-125a/b, enabling maintenance of the stem cell properties of hepatoblasts.

  8. LIN28A (show LIN28A Antibodies) and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  9. The identification of the let-7/Lin28 (show LIN28A Antibodies) axis as an important regulator of HSC (show FUT1 Antibodies) activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis

  10. data point toward a complex system of regulation by Lin28a (show LIN28A Antibodies), Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner

LIN28B Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene names and symbols associated with LIN28B

  • lin-28 homolog B (LIN28B) antibody
  • lin-28 homolog B (lin28b) antibody
  • lin-28 homolog B S homeolog (lin28b.S) antibody
  • lin-28 homolog B (C. elegans) (Lin28b) antibody
  • lin-28 homolog B (C. elegans) (LIN28B) antibody
  • lin-28 homolog B (Lin28b) antibody
  • 2810403D23Rik antibody
  • CSDD2 antibody
  • D030047M17Rik antibody
  • LIN-28 antibody
  • Lin-28.2 antibody

Protein level used designations for LIN28B

lin-28 homolog B (C. elegans) , lin-28 homolog B , Lin-28.2 , lin-28B , protein lin-28 homolog B

GENE ID SPECIES
481943 Canis lupus familiaris
737588 Pan troglodytes
100216028 Xenopus (Silurana) tropicalis
100221494 Taeniopygia guttata
373796 Xenopus laevis
389421 Homo sapiens
380669 Mus musculus
421786 Gallus gallus
540646 Bos taurus
689054 Rattus norvegicus
Selected quality suppliers for anti-LIN28B (LIN28B) Antibodies
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