anti-Lin-28 Homolog B (C. Elegans) (LIN28B) Antibodies

The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. Additionally we are shipping LIN28B Proteins (8) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LIN28B 389421 Q6ZN17
LIN28B 380669 Q45KJ6
LIN28B 689054  
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Top anti-LIN28B Antibodies at antibodies-online.com

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, WB   0.4 mL 4 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC, ELISA, WB Confocal immunofluorescent analysis of LIN28B antibody and HepG2 cells with Alexa Fluor 488-conjugated secondary (green). DAPI was used to stain the cell nuclear (blue). Flow cytometric analysis of HL-60 cells using LIN28B antibody (green) 0.4 mL 2 to 3 Days
$452.38
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Hela and 293 cells using LIN28B Antibody 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC, WB Western blot analysis of extracts of HEK-293 cells, using LIN28B antibody. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of LIN28B Antibody in HL60 cell line lysates (35ug/lane) Flow cytometric analysis of HL-60 cells using LIN28B Antibody (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Antibody staining LIN28B in human testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Antibody staining LIN28B in human testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated FACS, IF, IHC, IHC (p), WB Anti-LIN28B antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ABIN1804039 concentration 10 µg/mL. Anti-LIN28B antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ABIN1804039 concentration 10 µg/mL. 200 μL 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Spleen (formalin-fixed, paraffin-embedded) stained with LIN28Bfollowed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Testis (formalin-fixed, paraffin-embedded) stained with LIN28Bfollowed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 0.2 mL 11 to 13 Days
$768.40
Details

Top referenced anti-LIN28B Antibodies

  1. Human Polyclonal LIN28B Primary Antibody for ELISA, WB - ABIN544112 : Guo, Chen, Ito, Watanabe, Ge, Kodama, Aburatani: Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. in Gene 2006 (PubMed)

More Antibodies against LIN28B Interaction Partners

Human Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. H19 depresses miR-196b to elevate LIN28B, resulting in accelerating cell proliferation in lung cancer.

  2. Decreased LIN28B expression is associated with preeclampsia.

  3. The results revealed the collaboration of two RNA-binding proteins, STAU1 and Lin28B, as a regulatory mechanism in neuronal differentiation.

  4. This study supports the impact of MKRN3 SNP rs12441827 on precocious puberty in Korean boys.

  5. LIN28 expression level is a key variable that sets the magnitude of protein translation mediated by a redistribution in Argonaute association, from let-7 to non-let-7 microRNA families, resulting in a global shift in cellular miRNA activity.

  6. Study provides evidence that cancer-testis (CT) genes LIN28B and was activated in lung adenocarcinoma (LUAD) patients. Its high expression is significantly associated with LUAD worse overall survival. Also, LIN28B promotes tumor proliferation and metastasis in vitro and in vivo.

  7. LIN28B was a direct target of miR-26a in ambient particulate matter-bound metal-triggered lung cancer.

  8. UFC1 has a promoting role in GC progression, at least in part, by acting as a miR-498 sponge and derepressing Lin28b expression, which would provide a novel biomarker for GC diagnosis and prognosis and offer a potential target for GC therapy.

  9. Study investigated the effects of LIN28B expression on lung tumorigenesis using LIN28B transgenic overexpression in an autochthonous KRAS(G12V)-driven mouse model. LIN28B accelerates tumor initiation and enhances cell proliferation leading to a shortened overall survival. In addition, LIN28B expression is found in 24% of KRAS-mutated cases.

  10. Study demonstrates the differential antagonistic functions of the LIN28B-short isoform against the LIN28B-long isoform through an inability to degrade LET-7, which leads to the novel premise that the short isoform may serve to counterbalance the long isoform during normal colonic epithelial homeostasis.

  11. In colon cancer cells, up-regulation of LIN28B increased BCL-2 expression, enhanced its stability and reduced its ubiquitination.

  12. Lin28B could facilitate gastric cancer stemness.

  13. downregulation of Lin28b by miR-125a partially accounts for its antiproliferative activity toward hepatocellular carcinoma cells.

  14. The effects of acetylated Lin28B on let-7a-1 and let-7g are similar to that of stable knockdown of Lin28B in H1299 cells. The new role of PCAF in mediating Lin28B acetylation and the specific release of its target microRNAs in H1299 cells may shed light on the potential application of let-7 in the clinical treatment of lung cancer patients

  15. High LIN28B is associated with cervical cancer.

  16. Data found that LIN28B expression is inhibited in hepatoma cells by miR-125b-5p promoting HBV replication.

  17. Studied the association between Lin28 homolog B (LIN28B) gene polymorphisms and Wilms tumor susceptibility in Chinese children.

  18. C allele frequency in rs314276 of LIN28B is associated with Central precocious puberty.

  19. Testing for a combination of elevated IMP3 and Lin28B levels could further facilitate the identification of a patient subgroup with the worst ovarian cancer prognosis.

  20. Lin28A and Lin28B are co-expressed colon cancer tissues and have functional similarities.

Mouse (Murine) Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. placental exosome-derived bta-miR-499 inhibits the activation of NF-kappaB via the Lin28B/let-7 axis.

  2. Lin28b/let-7 axis controls the duration of kidney development

  3. Regulating the IL-1beta/miR-i101/Lin28B signaling pathway.

  4. The study deciphered the essential role of Lin28B in the pathogenesis of epithelial-mesenchymal transition in idiopathic pulmonary fibrosis, and unraveled a novel mechanism that miR-26a is a modulator of let-7d.

  5. Study generated transgenic mice that either overexpressed Lin28b in Math1-positive cerebellar granule neuron precursors or in a broad range of Nestin-positive neural precursors; while overexpression of LIN28B in Nestin-positive cells does not lead to tumor formation, it results in a protracted development of granule cells and inhibitory interneurons and leads to a hypersublobulation of the cerebellar vermis.

  6. this study shows that ectopic Lin28b expression reinitiates fetal regenerative potential in a subset of adult hematopoietic stem cells

  7. expression of the heterochronic factor Lin28b decreases in common myeloid progenitors during hematopoietic maturation to adulthood in mice.

  8. loss of Lin28b expression in fetal T cells leads to increased mature let-7, which causes decreased expression of TGF-betaRI, TGF-betaRIII, and SMAD2 proteins. A reduction in TGF-beta signaling leads to reduced Treg numbers.

  9. Lin28b positively regulates the expression of Lin28b itself and cell cycle-related proteins in hepatoblasts by suppressing the maturation of target microRNAs, lethal-7b and miR-125a/b, enabling maintenance of the stem cell properties of hepatoblasts.

  10. LIN28A and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  11. The identification of the let-7/Lin28 axis as an important regulator of HSC activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis

  12. data point toward a complex system of regulation by Lin28a, Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner

  13. Lin28B/let-7 axis acts as a critical driver of peripheral nervous system myelination

  14. These results implicate a key role for the LIN28B/let-7 axis in regulating postnatal supporting cell plasticity.

  15. Upregulation of LIN28B is associated with systemic mastocytosis.

  16. Lin28a and Lin28b have overlapping functions in temporally regulating neural progenitor cell proliferation during early brain development.

  17. VH repertoire of Lin28b-induced BM B1a B cells differs from that of normal B1a, suggesting persisting differences from fetal progenitors.

  18. Our data imply dual repression of Let-7 during oocyte-embryo transition in the mouse model, the selective suppression of Let-7 biogenesis by Lin28 homologs superimposed on previously reported global suppression of miRNA activity.

  19. Data implicate fetal expression of Lin28a/b in the regulation of life-long effects on metabolism and growth.

  20. MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging

LIN28B Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene names and symbols associated with LIN28B

  • lin-28 homolog B (LIN28B) antibody
  • lin-28 homolog B (lin28b) antibody
  • lin-28 homolog B S homeolog (lin28b.S) antibody
  • lin-28 homolog B (C. elegans) (Lin28b) antibody
  • lin-28 homolog B (C. elegans) (LIN28B) antibody
  • lin-28 homolog B (Lin28b) antibody
  • 2810403D23Rik antibody
  • CSDD2 antibody
  • D030047M17Rik antibody
  • LIN-28 antibody
  • Lin-28.2 antibody

Protein level used designations for LIN28B

lin-28 homolog B (C. elegans) , lin-28 homolog B , Lin-28.2 , lin-28B , protein lin-28 homolog B

GENE ID SPECIES
481943 Canis lupus familiaris
737588 Pan troglodytes
100216028 Xenopus (Silurana) tropicalis
100221494 Taeniopygia guttata
373796 Xenopus laevis
389421 Homo sapiens
380669 Mus musculus
421786 Gallus gallus
540646 Bos taurus
689054 Rattus norvegicus
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