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The protein encoded by LPPR4 belongs to the lipid phosphate phosphatase (LPP) family. Additionally we are shipping Lipid Phosphate Phosphatase-Related Protein Type 4 Antibodies (44) and and many more products for this protein.
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RG-1-deficient (KO) mice have deficits in sensorimotor integration and whisker-based sensory discrimination; genetic ablation of PRG-1 modulates postnatal day 16-19 spontaneous and evoked excitability of the barrel cortex, including enhancement of thalamocortical glutamatergic inputs to Layer 4; data strongly indicate that PRG-1 is required for the developmental, activity-dependent fine-tuning of sensory cortex function
Endogenous PRG3 promotes neurite shaft protrusion and therefore contributes to regulating filopodia formation in immature neurons.
PRG-1 as an important player in the modulatory control of hippocampal excitability dependent on presynaptic LPA(2) receptor signaling.
Glycosylation as a critical mechanism for PRG-1 function was significantly reduced by the PRG-1R346T SNP glycosylation as a critical mechanism
The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
lipid phosphate phosphatase-related protein type 4
, plasticity related gene 1
, brain-specific phosphatidic acid phosphatase-like protein 1
, plasticity-related gene 1 protein