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At the relatively small concentrations in tears, all ceramides were complexed to tear lipocalin.
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Human neutrophil lipocalin (HNL) concentrations in serum or whole blood activated by formyl-methionine-leucine-phenylalanine (fMLP) were shown to distinguish acute infections of bacterial or viral cause with high accuracy.
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the possible relationship between ocular symptomatology, tear volume and tear break-up time (TBUT) and lipocalin, lactoferrin and lysozyme concentrations in the tear film were explored in a group of symptomatic dry-eyed postmenopausal (PM) women.
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Tear lysozyme, lactoferrin and lipocalin concentrations were determined via electrophoresis and the results for patients with or without eyelid tumors were compared.
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the crosstalk of dendritic cells with lipocalins alone has the potential to direct the type of immune response to these particular antigens.
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Serum concentrations of LCN1 and LCN2 were both elevated in patients with COPD.
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Tear lipocalin (TLC) is a major protein in tears and has a large ligand-binding cavity that allows the lipocalin to bind an extensive and diverse set of lipophilic molecules.
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Study has identified the first protein, lipocalin-1, in the secretome of human blastocysts that is associated with chromosome aneuploidy.
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The conserved disulfide bond of human tear lipocalin modulates conformation and lipid binding in a ligand selective manner.(
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Tear lipocalin with the bound artificial ligand 1,4-butanediol has been crystallized in space group P2(1) with four protein molecules in the asymmetric unit and its X-ray structure has been solved at 2.6 A resolution.
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The N-terminal part of recombinant human tear lipocalin/von Ebner's gland protein confers cysteine proteinase inhibition depending on the presence of the entire cystatin-like sequence motifs.
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Lcn-1 is specifically produced by corticotrophs
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LIMR mediating internalization of lipocalin-1 (Lcn-1) in NT2 cells, leading to its degradation.
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structure, function, and mechanism of action [review]
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Tear lipocalin is probable protein carrier for vitamin E tears and is candidate to specifically deliver vitamin E as antioxidant to corneal epithelium.
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Tear surface tension depends partly on presence of tear lipocalin/lipid complex. Tear proteins and lipid-free tear lipocalin lower surface tension.
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pH-driven ligand release involves ionization changes in several titratable residues associated with CD and EF loop apposition and occlusion of the calyx
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structural analysis sheds new light on the ligand binding activity of this functionally obscure but abundant human lipocalin
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Lipocalin is a novel autoantigen target in Sjogren's syndrome.
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Hydrodynamic and solution properties of lipocalin from human tears show that the protein size and topology are the major determinants of rotational correlation time and a reason for deviation from the Stokes-Einstein relationship.
