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LRP8 encodes a member of the low density lipoprotein receptor (LDLR) family. Additionally we are shipping LRP8 Antibodies (93) and LRP8 Kits (14) and many more products for this protein.
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This study elucidates that the contracted-open conformation of ligand-bound ApoER2 at neutral pH resembles the contracted-closed conformation of ligand-unbound low-density lipoprotein receptor (show LDLR Proteins) at acidic pH in a manner suggestive of being primed for ligand release even prior to internalization.
LRP8 is a risk gene for psychosis.
These results reveal an association between ApoER2 isoform expression and Alzheimer's disease.
The presence of reelin (show RELN Proteins) was elevated in junctional areas as in dysplastic nevi. VLDLR (show VLDLR Proteins) presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases.
ApoER2 contributes cooperatively with endothelial cell protein C receptor (show PROCR Proteins) and protease activated receptor 1 (show F2R Proteins) to APC (show APC Proteins)-initiated endothelial antiapoptotic and barrier protective signaling.
two SNPs (rs3737984 and rs2297660) in ApoER2 gene had significant association with dyslipidemia in Thai ethnic
A novel TACGC risk haplotype in the LRP8 gene that is present in patients with CAD and MI but not in normal controls.
results of this study demonstrated the presence of reelin (show RELN Proteins), its receptors VLDLR (show VLDLR Proteins) and ApoER2 as well as Dab1 (show DAB1 Proteins) in the ENS and might indicate a novel role of the reelin (show RELN Proteins) system in regulating neuronal plasticity and pre-synaptic functions in the ENS.
Data suggest that PS1 (show PSEN1 Proteins)/gamma-secretase-dependent processing of the reelin (show RELN Proteins) receptor ApoER2 inhibits reelin (show RELN Proteins) expression and may regulate its signaling.
ectopic expression of HIC1 (show HIC1 Proteins) in U2OS and MDA-MB-231 cell lines decreases expression of the ApoER2 and VLDLR (show VLDLR Proteins) genes, encoding two canonical tyrosine kinase (show TXK Proteins) receptors for Reelin (show RELN Proteins).
A1-A1, which is a soluble analog of ApoER2 that binds pathological beta2GPI/anti-beta2GPI complexes, has a positive impact on hemodynamics in lupus-prone mice with spontaneous anti-beta2GPI antibodies and hypertension
findings indicate that impaired processing or localization of apoER2 may contribute to the pathogenic effects of familial Alzheimer's disease mutations in PS1 (show PSEN1 Proteins)
reveals a novel function for Reelin (show RELN Proteins)/ApoER2 in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration
total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn (show FYN Proteins)
This study demonstrated that ApoER2 is expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex.
This study demonistrated that LRP8-Reelin (show RELN Proteins)-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation in mice.
Apoer2 lacking exon 16, the O-linked sugar domain, altered the proteolytic processing and abundance of Apoer2 in cells and synapse number and function in mice, hippocampal spine density, LTP (show SCP2 Proteins), and cued fear learning.
genetic variants of apoE (show APOE Proteins) and ApoER2 impact cardiovascular health by differentially modulating endothelial function.
Study shows that the levels of hippocampal ApoE (show APOE Proteins) receptors Lrp1 (show LRP1 Proteins) and Apoer2 in vivo are affected isoform specifically by ApoE4 and that the type of receptor affected is context dependent
Tandem Sepp1 (show SEPP1 Proteins)-apoER2 interactions supply selenium for maintenance of brain neurons both at the blood-brain barrier and within the brain. Sepp1 (show SEPP1 Proteins) inside the blood-brain barrier is taken up by neurons via apoER2, concentrating brain selenium in them.
genetic variants of apoE (show APOE Proteins) and ApoER2 impact cardiovascular health by differentially modulating endothelial function.[ApoER2]
the differential expression patterns of LRP8 mRNA during final follicular growth and ovulation
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
, low density lipoprotein receptor-related protein 8
, low-density lipoprotein receptor-related protein 8-like
, ApoE receptor 2
, low-density lipoprotein receptor-related protein 8
, apolipoprotein E receptor 2
, low density lipoprotein receptor relative, 8 ligand binding repeats, brain