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Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.. Additionally we are shipping Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 Antibodies (98) and Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 Proteins (22) and many more products for this protein.
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data also reveal that D1D2 is able to bind to a second distinct site on LRP1 (show LRP1 ELISA Kits) to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor
The clinical and biometric features we describe in this report characterize LRPAP1-related high myopia and should raise suspicion for mutations in the gene.
The inhibition caused by reagents that prevented the activation of Rap was reversed by mobilizing intracellular calcium pharmacologically, whereas that caused by acrosome reaction inhibitors that impeded Rab3's binding to GTP (show AK3 ELISA Kits) was not.
The LRPAP1 I allelic variant may be considered a candidate gene for PD, predominantly in patients having the APOE (show APOE ELISA Kits) epsilon4 allelic variant.
RAP inhibited light chain (LC)endocytosis by approximately 88% and ameliorated LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells.
Mutations in LRPAP1 are associated with severe myopia in humans.
Data indicate that the region of complement-type repeats 2-5 in LDLR (show LDLR ELISA Kits) was identified as the binding site for FVIII (show F8 ELISA Kits) and for alpha-2-macroglobulin receptor-associated protein (RAP).
LRP1 (show LRP1 ELISA Kits)-C/T, A2M (show A2M ELISA Kits)-Ile/Val and APOE (show APOE ELISA Kits)-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD.
Findings reveal that RAP is a novel Abeta (show APP ELISA Kits)-binding protein that promotes cellular internalization of Abeta (show APP ELISA Kits).
Adenoviral-mediated expression of human receptor-asociated protein RAP in a murine model of von Willebrand disease results in a continuous rise in FVIII (show F8 ELISA Kits) over 6 days.
RAP deficiency attenuated atherosclerosis without influencing abdominal aortic aneurysms in hypercholesterolemic mice infused with angiotensin II.
In RAP-deficient mice megalin expression was strongly reduced and restricted to a subapical localization and NaP(i)-IIa protein distribution and abundance in the kidney was not altered.
the His-sRAP-induced acceleration of megalin (show LRP2 ELISA Kits)-mediated endocytosis causes phosphaturia via altered subcellular distribution of NaPi-II [39-kD receptor-associated protein (RAP)]
Results suggest that receptor-associated protein (show BCAP31 ELISA Kits) is required for the establishment of thyroglobulin (show TG ELISA Kits) reservoirs, but its absence does not affect hormone secretion.
RAP binds to LPL (show LPL ELISA Kits) with high affinity both in purified systems and cell extracts and RAP-deficient adipocytes secrete poorly assembled LPL (show LPL ELISA Kits)
RAP is expressed by thyrocytes in a TSH-dependent manner, both in cultured thyroid cells and in vivo
Disruption of the RAP gene determines not only thyroid abnormalities, but also a severe defect of megalin (show LRP2 ELISA Kits) expression and function in the kidney.
Receptor-associated protein (RAP) plays a central role in modulating Abeta (show APP ELISA Kits) deposition in APP (show APP ELISA Kits)/PS1 (show PSEN1 ELISA Kits) transgenic mice
Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
alpha-2-macroglobulin receptor-associated protein
, low density lipoprotein receptor-related protein associated protein 1
, alpha-2-macroglobulin receptor-associated protein 1
, lipoprotein receptor associated protein
, low density lipoprotein receptor-related protein-associated protein 1
, low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
, receptor-associated protein
, gp330-binding 45 kDa protein
, Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44)
, heparin-binding protein 44
, low density lipoprotein receptor related protein, associated protein 1