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Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. Additionally we are shipping LCP1 Antibodies (118) and LCP1 Proteins (6) and many more products for this protein.
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Human LCP1 ELISA Kit for Sandwich ELISA - ABIN415176
Zaidi, Gopalakrishnan, Kasi, Zeng, Malhotra, Balasubramanian, Visweswaran, Sun, Flint, Davison, Hood, Conrads, Bergman, Bigbee, Jobe: Evaluation of a 4-protein serum biomarker panel-biglycan, annexin-A6, myeloperoxidase, and protein S100-A9 (B-AMP)-for the detection of esophageal adenocarcinoma. in Cancer 2014
Human LCP1 ELISA Kit for Sandwich ELISA - ABIN843770
Oztürk, Emingil, Osterwalder, Bostanci: The actin-bundling protein L-plastin: a novel local inflammatory marker associated with periodontitis. in Journal of periodontal research 2014
LCP1-positive oral squamous cell carcnome samples were correlated closely with the primary tumor size and regional lymph node metastasis.
MOLP8/R cells display a very high overexpression of LCP1 gene (l-Plastin) controlled by HIF1&alpha (show HIF1A ELISA Kits).
these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment.
Mutated LCP1 is a driver of chronic lymphocytic leukemia.
AngII-dependent phosphorylation of LCP1 in cultured podocytes was mediated by the kinases ERK (show EPHB2 ELISA Kits), p90 (show CANX ELISA Kits) ribosomal S6 kinase (show RPS6KB1 ELISA Kits), PKA, or PKC. LCP1 phosphorylation increased filopodia formation.
L-plastin regulates the stability of the immune synapse of naive and effector T-cells. (Review)
The findings support a mechanism in which miR-375 suppresses RUNX1 levels, resulting in reduced vimentin and L-plastin expression. Knockdown of RUNX1, L-plastin, and vimentin resulted in significant reductions in cell invasion in vitro, indicating the functional significance of miR-375 regulation of specific proteins involved in head and neck squamous cell carcinoma (HNSCC) invasion.
In this study, the authors found that the actin filament bundling abilities of PLS1 and PLS2 were similarly sensitive to Ca(2+) (pCa50 ~6.4), whereas PLS3 was less sensitive (pCa50 ~5.9).
elevated L-plastin expression promotes elongation and reduces protrusion density in cells with relatively lower L-plastin than fascin (show FSCN1 ELISA Kits) levels.
Enhanced nitroxidative stress may results in LPL S-glutathionylation leading to impaired chemotaxis, polarization, and bactericidal activity of human neutrophils.
the actin-bundling protein L-plastin (LPL) is required for the perinatal development of alveolar macrophages.
Results identify L-plastin as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein critical to T cell migration.
L-plastin modulates both T- and B-cell function during the germinal center reaction and the production of T-cell-dependent antibody responses.
L-plastin may participate in signaling that enables lymphocyte transmigration
LPL-dependent actin bundling facilitates the formation of lamellipodia and normal immunological synapses and thereby enables T cell activation.
Regulation of sealing ring formation by L-plastin and cortactin (show CTTN ELISA Kits) in osteoclasts.
We thus identify L-plastin as a molecule critical for CCR7 (show CCR7 ELISA Kits)-mediated t-cell motility but dispensable for early CCR7 (show CCR7 ELISA Kits) signaling.
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)
, Lymphocyte cytosolic protein-1 (plasmin)
, bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin))
, plastin 2
, leucocyte-specific plastin 1
, 65 kDa macrophage protein
, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65)
, plastin 2, L
, 65 kDa matrix phosphoprotein
, Phosphoprotein UL83
, Tegument protein UL83
, involved in immune regulation
, lower matrix protein
, tegument protein pp65