Lysine (K)-Specific Demethylase 4A Proteins (KDM4A)

KDM4A is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Additionally we are shipping KDM4A Antibodies (104) and KDM4A Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM4A 9682 O75164
KDM4A 230674 Q8BW72
Rat KDM4A KDM4A 313539  
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Top KDM4A Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
Baculovirus Human DYKDDDDK Tag JMJD2A / KDM4A activity assay. Recombinant JMJD2A / KDM4A activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JMJD2A / KDM4A protein gel. JMJD2A / KDM4A protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
Baculovirus infected Insect Cells Human GST tag   20 μg Log in to see 1 to 2 Days

KDM4A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Mouse (Murine)

More Proteins for Lysine (K)-Specific Demethylase 4A (KDM4A) Interaction Partners

Human Lysine (K)-Specific Demethylase 4A (KDM4A) interaction partners

  1. Crystallographic studies of an histone H1.4K26me3:lysine demethylase 4A (KDM4A) complex iidicate a conserved binding geometry to that of H3K9me3.

  2. This suggests that KDM4A can enhance the function of HIF-1alpha by increasing the total available protein to counteract any residual activity of prolyl hydroxylases.

  3. Knockdown of KDM4A expression or inhibition of KDM4 enzyme activity reduces the proliferation of PCa cell lines.

  4. MiR150 plays an important role in the development of lung cancer by serving as an oncogene via the SIRT2/JMJD2A signaling pathway.

  5. Data show that lysine demethylase 4 A/B double tudor domains (KDM4A/B DTDs) bind strongly to histone H3 (H3)K23me3.

  6. Generation of 2-hydroxyglutarate by mutated IDH1/2 leads to the activation of mTOR by inhibiting KDM4A.

  7. The present study indicates a novel evidence for JMJD2A in tumorigenesis by upregulating miR372 in liver cancer cells.

  8. JMJD2A regulated aerobic glycolysis by regulating LDHA expression. Therefore, the novel JMJD2A-LDHA signaling pathway could contribute to the Warburg effects in NPC progression.

  9. These results reveal KDM4A as a key epigenetic silencer of TRAIL and DR5 in tumors.

  10. Findings inidicate a unique breast cancer stem-like cells (BCSC) culture system for drug screening and offer preclinical proof of concept for lysine demethylase 4A (KDM4A) inhibition as a new strategy to treat triple-negative breast cancer.

  11. The pyruvate dehydrogenase kinases (PDKs) PDK1 and PDK3 are direct targets of KDM4A and E2F1 and modulate the switch between glycolytic metabolism and mitochondrial oxidation.

  12. results suggest that KDM4A possesses the potential to act as an oxygen sensor in the context of chromatin modifications, with possible implications for epigenetic regulation in hypoxic disease states

  13. Here we show that JMJD2A, the first identified Jumonji C domain-containing histone demethylase, is the histone demethylase responsible for SUMO-2/3 enrichment on the Kaposi's sarcoma associated herpesvirus genome during viral reactivation

  14. Lgr4 activates Jmjd2a/AR signaling pathway to promote interaction AR with PSA promoter, causing reduction of prostate cancer apoptosis and cell cycle arrest.

  15. We demonstrate the previously unreported inhibitory action of PKF118-310 on KDM4A. Our findings open up the possibility of developing the first KDM4A-specific inhibitors and derivatives.

  16. KDM4A downregulation promotes autophagy in glioma cell lines.

  17. ERG promotes prostate tumorigenesis together with KDM4A through the upregulation of YAP1. A corollary is that KDM4A as well as YAP1 inhibitors may prove beneficial for the therapy of ERG-overexpressing prostate tumors.

  18. In pancreatic neoplasms, miR-137 targets KDM4A mRNA during Ras-induced senescence and activates both p53 and retinoblastoma (pRb) tumor suppressor pathways.

  19. Study demonstrates that JMJD2A contributes to tumorigenesis in non-small cell lung cancer (NSCLC) by regulating miR-150. Additionally, JMJD2A overexpression is associated with a poor prognosis for NSCLC patients.

  20. High KDM4A expression is associated with endometrial cancer progression.

Mouse (Murine) Lysine (K)-Specific Demethylase 4A (KDM4A) interaction partners

  1. Jmjd2 class demethylases are critical epigenetic regulators involved in etiopathology of depression and related disorders.

  2. High Jmjd2a expression is associated with neuropathic pain.

  3. This study dissects an important dual role for maternal Kdm4a in determining faithful early embryonic development and the implantation process.

  4. We propose the inhibition of KDM4A activity as a strategy to suppress IL-6 production and attenuate colitis induction.

  5. The authors show that Jmjd2a and Jmjd2c both localize to H3K4me3-positive promoters, where they have widespread and redundant roles in preventing accumulation of H3K9me3 and H3K36me3.

  6. these data reveal a JMJD2A/ETV1/YAP1 axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition.

  7. Results indicate that SCF(Fbxo22)-KDM4A is an E3 ubiquitin ligase that targets methylated p53 and regulates key senescent processes.

  8. These findings together demonstrate the essential role of KDM4A and KDM4C in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 and VE-cadherin promoters, respectively

  9. As well as three novel motifs in JMJD2A-regulated genes.

  10. Overexpression of KDM4 proteins induces numerous oncogenic effects. (Review)

  11. JMJD2A bound to the FHL1 promoter in response to TAC, upregulated FHL1 expression, and downregulated H3K9 trimethylation. JMJD2A promotes cardiac hypertrophy under pathological conditions by a novel mechanism.

  12. JHDM3A(GFP)(701) is a suitable catalytic module that can be targeted, under the control of a guide protein, to specific loci where the chromatin H3K9me3 status and the milieu of gene expression are to be modified.

Cow (Bovine) Lysine (K)-Specific Demethylase 4A (KDM4A) interaction partners

  1. Histone demethylases KDM3A, KDM4A, and KDM4C were expressed before and after embryonic genome activation, whereas KDM5B was mainly expressed during the blastocyst period.

KDM4A Protein Profile

Protein Summary

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.

Gene names and symbols associated with KDM4A

  • lysine demethylase 4A (KDM4A)
  • lysine-specific demethylase 4A (LOC100228023)
  • lysine (K)-specific demethylase 4A (KDM4A)
  • lysine (K)-specific demethylase 4A (Kdm4a)
  • lysine demethylase 4A (Kdm4a)
  • D4Ertd222e protein
  • JHDM3A protein
  • Jmjd2 protein
  • Jmjd2a protein
  • mKIAA0677 protein
  • TDRD14A protein

Protein level used designations for KDM4A

jumonji domain containing 2A , lysine (K)-specific demethylase 4A , lysine-specific demethylase 4A , jumonji domain-containing protein 2A , JmjC domain-containing histone demethylation protein 3A , jumonji domain-containing 2A , lysine-specific demethylase 4A-like , jmjC domain-containing histone demethylation protein 3A , jumonji C domain-containing histone demethylase 3A , jumonji domain containing 2 , tudor domain containing 14A

424571 Gallus gallus
456829 Pan troglodytes
701272 Macaca mulatta
100172003 Pongo abelii
100353935 Oryctolagus cuniculus
100228023 Taeniopygia guttata
100294710 Sus scrofa
100473204 Ailuropoda melanoleuca
100544296 Meleagris gallopavo
9682 Homo sapiens
230674 Mus musculus
313539 Rattus norvegicus
482530 Canis lupus familiaris
512622 Bos taurus
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