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KDM4A is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Additionally we are shipping KDM4A Antibodies (111) and KDM4A Kits (5) and many more products for this protein.
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MiR150 plays an important role in the development of lung cancer by serving as an oncogene (show RAB1A Proteins) via the SIRT2 (show SIRT2 Proteins)/JMJD2A signaling pathway.
Data show that lysine demethylase (show MBD2 Proteins) 4 A/B double tudor domains (KDM4A/B DTDs) bind strongly to histone H3 (show HIST3H3 Proteins) (H3)K23me3.
Generation of 2-hydroxyglutarate by mutated IDH1 (show IDH1 Proteins)/2 leads to the activation of mTOR (show FRAP1 Proteins) by inhibiting KDM4A.
The present study indicates a novel evidence for JMJD2A in tumorigenesis by upregulating miR372 in liver cancer cells.
JMJD2A regulated aerobic glycolysis by regulating LDHA (show LDHA Proteins) expression. Therefore, the novel JMJD2A-LDHA (show LDHA Proteins) signaling pathway could contribute to the Warburg effects in NPC (show NPC1 Proteins) progression.
These results reveal KDM4A as a key epigenetic silencer of TRAIL and DR5 (show TNFRSF10B Proteins) in tumors.
Findings inidicate a unique breast cancer stem-like cells (BCSC) culture system for drug screening and offer preclinical proof of concept for lysine demethylase (show MBD2 Proteins) 4A (KDM4A) inhibition as a new strategy to treat triple-negative breast cancer.
The pyruvate dehydrogenase (show PDP Proteins) kinases (PDKs) PDK1 (show PDK1 Proteins) and PDK3 (show PDK3 Proteins) are direct targets of KDM4A and E2F1 (show E2F1 Proteins) and modulate the switch between glycolytic metabolism and mitochondrial oxidation.
results suggest that KDM4A possesses the potential to act as an oxygen sensor in the context of chromatin modifications, with possible implications for epigenetic regulation in hypoxic disease states
Here we show that JMJD2A, the first identified Jumonji (show JARID2 Proteins) C domain-containing histone demethylase (show MBD2 Proteins), is the histone demethylase (show MBD2 Proteins) responsible for SUMO-2 (show SUMO2 Proteins)/3 enrichment on the Kaposi's sarcoma associated herpesvirus genome during viral reactivation
Jmjd2 class demethylases are critical epigenetic regulators involved in etiopathology of depression and related disorders.
High Jmjd2a expression is associated with neuropathic pain.
This study dissects an important dual role for maternal Kdm4a in determining faithful early embryonic development and the implantation process.
We propose the inhibition of KDM4A activity as a strategy to suppress IL-6 (show IL6 Proteins) production and attenuate colitis induction.
The authors show that Jmjd2a and Jmjd2c (show KDM4C Proteins) both localize to H3K4me3-positive promoters, where they have widespread and redundant roles in preventing accumulation of H3K9me3 and H3K36me3.
these data reveal a JMJD2A/ETV1 (show ETV1 Proteins)/YAP1 (show YAP1 Proteins) axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition.
Results indicate that SCF (show KITLG Proteins)(Fbxo22 (show FBXO22 Proteins))-KDM4A is an E3 ubiquitin ligase (show MUL1 Proteins) that targets methylated p53 (show TP53 Proteins) and regulates key senescent processes.
These findings together demonstrate the essential role of KDM4A and KDM4C (show KDM4C Proteins) in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 (show KDR Proteins) and VE-cadherin (show CDH5 Proteins) promoters, respectively
As well as three novel motifs in JMJD2A-regulated genes.
JMJD2A bound to the FHL1 (show FHL1 Proteins) promoter in response to TAC (show IL2RA Proteins), upregulated FHL1 (show FHL1 Proteins) expression, and downregulated H3K9 trimethylation. JMJD2A promotes cardiac hypertrophy under pathological conditions by a novel mechanism.
Histone demethylases KDM3A (show KDM3A Proteins), KDM4A, and KDM4C (show KDM4C Proteins) were expressed before and after embryonic genome activation, whereas KDM5B (show KDM5B Proteins) was mainly expressed during the blastocyst period.
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
jumonji domain containing 2A
, lysine (K)-specific demethylase 4A
, lysine-specific demethylase 4A
, jumonji domain-containing protein 2A
, JmjC domain-containing histone demethylation protein 3A
, jumonji domain-containing 2A
, lysine-specific demethylase 4A-like
, jmjC domain-containing histone demethylation protein 3A
, jumonji C domain-containing histone demethylase 3A
, jumonji domain containing 2
, tudor domain containing 14A