anti-Lysine (K)-Specific Demethylase 5C (KDM5C) Antibodies

KDM5C is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. Additionally we are shipping KDM5C Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KDM5C 8242 P41229
KDM5C 20591 P41230
KDM5C    
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Top anti-KDM5C Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IP, WB Western Blot and Immunoprecipitation: JARID1C Antibody [ABIN188638] - Detection of Human JARID1C by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-JARID1C antibody ABIN188638 used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. JARID1C was also immunoprecipitated by rabbit anti-JARID1C antibody ABIN188637, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A and B). 0.1 mL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated ELISA, WB 50 μL Log in to see 2 to 3 Days
$185.00
Details
Cow Mouse Un-conjugated ICC, IF, IHC, IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Mouse Un-conjugated ELISA, WB   100 μL Log in to see Available
$363.46
Details
Human Rabbit Un-conjugated IP, WB Western Blot and Immunoprecipitation: JARID1C Antibody [ABIN188637] - Detection of Human JARID1C by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-JARID1C antibody ABIN188637 used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. JARID1C was also immunoprecipitated by rabbit anti-JARID1C antibody ABIN188638, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A and B). Western Blot: SMCX Antibody  - Detection of Human and Mouse Jarid1C by Western Blot. Samples: Whole cell lysate (50, 15 ug) from HeLa and (50 ug) from 293T, Jurkat, and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Jarid1C antibody  used for WB at 0.04 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 0.1 mL Log in to see 7 to 9 Days
$559.35
Details
Human Mouse Un-conjugated ICC, WB Western blot analysis of extracts of various cells, using JARID1C antibody. 100 μL Log in to see 11 to 13 Days
$433.51
Details
Cow Mouse Un-conjugated IF, WB   100 μL Log in to see Available
$546.20
Details
Human Rabbit Un-conjugated ChIP, WB .JARID1C / KDM5C pAb tested by ChIP. Chromatin immunoprecipitation (ChIP) was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 µg of chromatin from human MIA PaCa-2 pancreatic carcinoma cells and 10 µl JARID1C / KDM5C antibody. ChIP DNA was used in qPCR with the control primer pairs or gene-specific primer pairs as indicated. Data are presented as Binding Events Detected per 1000 Cells using Active Motif's Epigenetic Services normalization scheme which accounts for primer efficiency and the amount of chromatin used in the ChIP reaction. JARID1C / KDM5C pAb tested by Western blot. Nuclear extract of HeLa cells (20 µg) probed with JARID1C / KDM5C pAb (1:1,000) 200 μL Log in to see 1 to 2 Days
$495.83
Details
Human Mouse Un-conjugated ICC, WB   100 μL Log in to see 12 to 14 Days
$200.00
Details

Top referenced anti-KDM5C Antibodies

  1. Human Polyclonal KDM5C Primary Antibody for IP, WB - ABIN188638 : Smith, Haberstroh, White, Livingston, DeCaprio, Howley: SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. in Virology 2014 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal KDM5C Primary Antibody for ChIP, WB - ABIN2668493 : Nishibuchi, Shibata, Hayakawa, Hayakawa, Ohtani, Sinmyozu, Tagami, Nakayama: Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. in The Journal of biological chemistry 2014 (PubMed)

More Antibodies against KDM5C Interaction Partners

Human Lysine (K)-Specific Demethylase 5C (KDM5C) interaction partners

  1. HPV16 E6 protein interacts with histone demethylase KDM5C in ovarian cancer.HPV16 E6 protein destabilizes the KDM5C.KDM5C regulates cervical cancer cell EGFR and c-MET expression by modulating their super-enhancer H3K4 methylation dynamics.

  2. In colon cancer cells, KDM5c might downregulate ABCC1 expression by demethylating the ABCC1 H3K4me3 in the TSS region, which can promote multidrug resistance

  3. SETD2 and KDM5C mutations were associated with prolonged overall survival in patients with metastatic clear cell renal cell carcinoma

  4. KDM5C expression was generally lower in cancer lesions compared with matched nontumor tissues. KDM5C has a vital function in inhibiting cell mobility, which is at least partially controlled by the p53.

  5. Mutation in KDM5C gene is associated with cancer more frequently in males.

  6. In vitro models indicated that KDM5C suppressed miR-320a transcription by directly binding to the promoter of miR-320a to prevent histone methylation. KITLG, an essential gene for ovarian development and primordial germ cell survival, was a direct target of miR-320a and that it was downregulated in 45,X fetal gonadal tissues.

  7. The two mutations are present on the same maternal haplotype, suggesting that a postzygotic somatic mutation or a reversion error occurred at an early embryonic stage in the mother, leading to switched KDM5C mutations in the affected siblings.

  8. The predicted structure of KDM5C was used to investigate the effects of disease-causing mutations, and it was shown that the mutations alter domain stability and inter-domain interactions.

  9. Results suggest that KDM5C mutations predispose to X-linked intellectual disability which accounts for 1-4% of cases in male patient.

  10. the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2, KDM5C and IQSEC2, is reported.

  11. KDM5C is overexpressed in breast cancer cells and miR-138 regulates its expression.

  12. study of non-synonymous mutations in the KDM5C ARID domain and evaluates effects of 2 syndromic Claes-Jensen-type disease-associated missense mutations (A77T and D87G) and 3 non-classified missense mutations (R108W, N142S, and R179H); analysis indicates, among the non-classified mutations, R108W is possibly a disease-associated mutation, and N142S and R179H are probably harmless

  13. Findings reveal a RACK7/KDM5C-regulated, dynamic interchange between histone H3K4me1 and H3K4me3 at active enhancers, representing an additional layer of regulation of enhancer activity. Authors propose that RACK7/KDM5C functions as an enhancer "brake" to ensure appropriate enhancer activity, which, when compromised, could contribute to tumorigenesis.

  14. Expression of KDM5C in hepatocellular carcinoma tumor cells promoted cell migration and tumor invasion.

  15. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

  16. these data suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs.

  17. Mutations in KDM5C gene in patients are described and their effect on gene expression, stability and catalytic activity is examined. Patient fibroblasts do not show global changes in histone methylation but several up-regulated genes were identified.

  18. BRMS1 expression in human breast cancer is negatively correlated with JARID1C expression. Our results, for the first time, portray a pivotal role of JARID1C in regulating metastatic behaviors of breast cancer cells

  19. Data indicate the role for histone demethylase KDM5C/JARID1C in a specific phase of DNA replication in mammalian cells, through its demethylase activity on histone H3K4me3.

  20. KDM5C is functionally involved in proliferation control of prostate cancer cells

Mouse (Murine) Lysine (K)-Specific Demethylase 5C (KDM5C) interaction partners

  1. Loss of Kdm5c causes spurious transcription and prevents the fine-tuning of activity-regulated enhancers in neurons.

  2. The results identify two key regulators, PCGF6 and JARID1c that temper dendritic cells (DC) activation and implicate active transcriptional silencing via histone demethylation as a previously unappreciated mechanism for regulating DC activation and quiescence.

  3. Neurite growth in Neuro2a cells was suppressed by the KDM5C mutations associated with intellectual disability in patients. Ntng2 was downregulated in cells with KDM5C mutations, concordant with the lower levels of H3K4 methylation at its promoter.

  4. these data suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs.

  5. The present study was designed to detect the expression of Histone H3 lysine 4 methylation and its demethylases LSD1, RBP2 and SMCX in 21-, 40- and 60-day-old mouse testes.

  6. Kdm5c protein restricts transcriptional output at promoters, whereas Kdm5c binding to enhancers stimulates their activity.

  7. sex-specific expression of Jarid1c may contribute to sex differences in brain function

  8. allelic expression and RNA/DNA FISH indicate that transgenic Jarid1c escapes X inactivation.

Pig (Porcine) Lysine (K)-Specific Demethylase 5C (KDM5C) interaction partners

  1. The full-length cDNA of JARID1C has been cloned.

KDM5C Antigen Profile

Protein Summary

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KDM5C

  • histone demethylase JARID1C (MGYG_04221) antibody
  • lysine-specific demethylase 5C (LOC100075501) antibody
  • lysine demethylase 5C (KDM5C) antibody
  • lysine demethylase 5C (kdm5c) antibody
  • lysine (K)-specific demethylase 5C (Kdm5c) antibody
  • lysine demethylase 5C (Kdm5c) antibody
  • DXS1272E antibody
  • Jarid1c antibody
  • mKIAA0234 antibody
  • MRXJ antibody
  • MRXSCJ antibody
  • MRXSJ antibody
  • Smcx antibody
  • XE169 antibody

Protein level used designations for KDM5C

histone demethylase JARID1C , lysine (K)-specific demethylase 5C , jumonji, AT rich interactive domain 1C , JmjC domain-containing protein SMCX , Jumonji, AT rich interactive domain 1C (RBP2-like) , Jumonji/ARID domain-containing protein 1C , Smcx homolog, X chromosome , Smcy homolog, X-linked , lysine-specific demethylase 5C , protein SmcX , selected cDNA on X , jumonji, AT rich interactive domain 1C (Rbp2 like) , jumonji/ARID domain-containing protein 1C , selected mouse cDNA on the X , lysine (K)-specific demethylase 5C tv1 , Lysine-specific demethylase 5C

GENE ID SPECIES
10029336 Arthroderma gypseum CBS 118893
100075501 Ornithorhynchus anatinus
100341721 Oryctolagus cuniculus
100565551 Anolis carolinensis
8242 Homo sapiens
20591 Mus musculus
491894 Canis lupus familiaris
100037295 Sus scrofa
281490 Bos taurus
100758549 Cricetulus griseus
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