KDM5C antibody

Catalog No. ABIN6655941

Product Details anti-KDM5C Antibody

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM5C antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Human, Mouse (Murine)

Cross-Reactivity (Details): Cross reactivity with Jarid1c from other species not tested.

Purification: Anti-Jarid1c Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Immunogen:

Immunogen: Anti-Jarid1c Antibody was produced in rabbits by repeated immunizations with three different synthetic peptides containing sequences from the inner part of the mouse Jarid1c protein.

Immunogen Type: Peptide

Application Details

Application Notes:

Application Note: Anti-Jarid1c Antibody is suitable for ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 175 kDa in the appropriate cell lysate or extract.

ELISA Dilution: 1:500

Western Blot Dilution: 1:1,000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

0.01 % (w/v) Sodium Azide

Stabilizer: None

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: RT,4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Target Details for KDM5C

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Alternative Name: Jarid1c (KDM5C Products)

Synonyms: DXS1272E antibody, JARID1C antibody, MRXJ antibody, MRXSCJ antibody, MRXSJ antibody, SMCX antibody, XE169 antibody, Jarid1c antibody, Smcx antibody, mKIAA0234 antibody, histone demethylase JARID1C antibody, lysine-specific demethylase 5C antibody, lysine demethylase 5C antibody, lysine (K)-specific demethylase 5C antibody, MGYG_04221 antibody, LOC100075501 antibody, KDM5C antibody, kdm5c antibody, Kdm5c antibody

Background:

Synonyms: Lysine-specific demethylase 5C, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169, DXS1272E, JARID1C, SMCX, XE169

Background: Jarid1c is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a internal role in the regulation of transcription and chromatin remodelling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form. Further, Jarid1c participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the Jarid1c gene have been associated with X-linked mental retardation. Anti-Jarid1c Antibody is ideal for research in Epigenetics, Gene Expression and Neuroscience.

Gene Name: KDM5C

Gene ID: 8242

NCBI Accession: NP_001140174

UniProt: P41229

Pathways: Warburg Effect