Lysine (K)-Specific Demethylase 6B (Kdm6b) ELISA Kits

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Additionally we are shipping Kdm6b Antibodies (99) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse Kdm6b Kdm6b 216850 Q5NCY0
Anti-Human Kdm6b Kdm6b 23135 O15054
Anti-Rat Kdm6b Kdm6b 363630  
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More ELISA Kits for Kdm6b Interaction Partners

Zebrafish Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. loss of both kdm6ba and kdm6bb shows Kdm6b proteins share redundant and pleiotropic roles in organogenesis without impacting initial cell fate specification.

  2. Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal (show CAD ELISA Kits) fin regeneration, and that Kdm6b.1 may be the histone demethylase (show MBD2 ELISA Kits) required during regeneration.

Mouse (Murine) Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. Results identified Kdm6b as a novel regulator of the pro-fibrotic signature of peritoneal foam cells.

  2. These results suggest that the demethylase (show MBD2 ELISA Kits) activity of Jmjd3, but not that of Utx (show KDM6A ELISA Kits), affects mouse axial patterning in concert with alterations in Hox (show MSH2 ELISA Kits) gene expression.

  3. Direct genetic and molecular evidence that JMJD3 is a key mediator for the kisspeptin-estrogen feedback loop.

  4. Knockdown of Kdm6b in chondrocytes leads to abnormal cartilage development and accelerated osteoarthritis progression via inhibition of the anabolic metabolism of chondrocytes. The number of Kdm6b-positive chondrocytes was lower in osteoarthritis cartilage samples.

  5. Preliminary evidence suggests a role of JMJD3 in removal of H3K27me3 mark from promoters of hepatic transcription factors, thus activating epigenetically poised hepatic genes in bone marrow progenitor cells prior to partial nuclear reprogramming.

  6. Study provides evidence that miR (show MLXIP ELISA Kits)-148a-3p reciprocally regulates adipocyte and osteoblast differentiation through directly targeting Kdm6b.

  7. the redox regulation of Jmjd3 is a unique regulatory mechanism for Cu,Zn-superoxide dismutase (show SOD1 ELISA Kits)-mediated profibrotic macrophage polarization.

  8. our study has attributed novel roles for JMJD3 and its regulators during mycobacterial infection that assist foamy macrophage generation and fine-tune associated host immunity

  9. ISL1 (show ISL1 ELISA Kits) and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation.

  10. Histone H3 (show HIST3H3 ELISA Kits) lysine-27 demethylase (show MBD2 ELISA Kits) (H3K27me3 demethylase (show MBD2 ELISA Kits)) activity would act as a negative regulator of dendritic cells (DCs).

Human Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 (show STAT6 ELISA Kits) target gene CCL18 (show CCL18 ELISA Kits), while induction of other STAT6 (show STAT6 ELISA Kits)-inducible genes such as SPINT2 (show SPINT2 ELISA Kits) remained unaffected by JMJD3.

  2. Here, we discuss the roles of lysine 27 demethylases, JMJD3 and UTX (show KDM6A ELISA Kits), in cancer and potential therapeutic avenues targeting these enzymes. Despite a high degree of sequence similarity in the catalytic domain between JMJD3 and UTX (show KDM6A ELISA Kits), numerous studies revealed surprisingly contrasting roles in cellular reprogramming and cancer, particularly leukemia

  3. inhibition of the H3K27 demethylase (show MBD2 ELISA Kits) JMJD3 in naive CD4 (show CD4 ELISA Kits) T cells demonstrates how critically important molecules required for T cell differentiation, such as JAK2 (show JAK2 ELISA Kits) and IL12RB2 (show IL12RB2 ELISA Kits), are regulated by H3K27me3.

  4. KDM6B expression strongly correlates with ERbeta (show ESR2 ELISA Kits) level in human pleural mesothelioma tumors and cell lines.

  5. Low JMJD3 expression is associated with breast cancer.

  6. results demonstrate that the regulation of Jmjd3 by STAT3 (show STAT3 ELISA Kits) maintains repression of differentiation specific genes and is therefore important for the maintenance of self-renewal of normal neural and glioblastoma stem cells

  7. Data show that histone demethylase (show MBD2 ELISA Kits) JMJD3 was reduced and its target gene Snai1 (show SNAI1 ELISA Kits) expression was down-regulated after HOTAIR suppression.

  8. The number of Kdm6b-positive chondrocytes was lower in human osteoarthritis cartilage samples.

  9. Kdm6a (show KDM6A ELISA Kits) and Kdm6b were found to be significantly overexpressed in Malignant pleural mesothelioma (MPM) at the mRNA level. However, tests examining if targeting therapeutically Kdm6a (show KDM6A ELISA Kits)/b using a specific small molecule inhibitor was potentially useful for treating MPM, revealed that members of the Kdm6 family may not be suitable candidates for therapy

  10. Lipopolysaccharide treatment recruited Jmjd3 and NF-kappaB (show NFKB1 ELISA Kits) to the promoter region of target genes, suggesting Jmjd3 synergizes with NF-kappaB (show NFKB1 ELISA Kits) to activate the expression of target genes.

Kdm6b Antigen Profile

Antigen Summary

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

Gene names and symbols associated with Kdm6b

  • lysine (K)-specific demethylase 6B (kdm6b) antibody
  • lysine demethylase 6B (KDM6B) antibody
  • lysine (K)-specific demethylase 6B, b (kdm6bb) antibody
  • KDM1 lysine (K)-specific demethylase 6B (Kdm6b) antibody
  • lysine demethylase 6B (Kdm6b) antibody
  • 1700064E03Rik antibody
  • BC038313 antibody
  • JMJD3 antibody
  • kdm6b antibody
  • mKIAA0346 antibody
  • si:ch211-237l4.7 antibody

Protein level used designations for Kdm6b

jumonji domain containing 3 , lysine (K)-specific demethylase 6B , jumonji domain containing 3, histone lysine demethylase , lysine-specific demethylase 6B-like , jmjC domain-containing protein 3 , jumonji domain-containing protein 3 , lysine-specific demethylase 6B , lysine demethylase 6B , jumonji domain-containing 3

GENE ID SPECIES
779446 Xenopus (Silurana) tropicalis
468438 Pan troglodytes
563644 Danio rerio
716348 Macaca mulatta
100414637 Callithrix jacchus
100140276 Bos taurus
100343083 Oryctolagus cuniculus
216850 Mus musculus
23135 Homo sapiens
489481 Canis lupus familiaris
363630 Rattus norvegicus
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