anti-Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Antibodies

Human Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) interaction partners

1. fetal LPCAT1 mRNA present in maternal blood in quantity that correlates with lamellar body count

2. The overexpression of LPCAT1 promotes the development and progression of ccRCC, likely through the conversion of LPC to PC.

3. We found a direct correlation between LPCAT1 mRNA copies and the amniotic fluid lamellar body count. This finding corroborates an association between LPCAT1 and surfactant phospholipid biosynthesis.

4. Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations are associated with Gastric Cancer

5. No disease causing mutations in the LPCAT1 gene were identified, indicating that LPCAT1 either does not confer a genetic predisposition to retinitis pigmentosa, or incidence of mutations in LPCAT1 is particularly rare in patients with retinitis pigmentosa.

6. Down-regulation of LPCAT1 resulted in a decreased intercellular platelet-activating factor concentration and PAFR expression.

7. LPCAT1 is an independent predictor of early tumor recurrence of breast carcinoma and represents a novel prognostic biomarker that reflects underlying biological alterations

8. LPCAT1, a gene involved in the remodeling of phospholipids, was nominally associated with incident SCA risk.

9. The prognostic impact of LPCAT1 expression was independent of histological and clinical parameters. It is concluded, that LPCAT1 measurement, either alone or in combination, may be utilized for better clinical decision-making.

10. effect of LPCAT1 overexpression or knockdown on cell proliferation, migration, and invasion in hepatocellular carcinoma cell lines

11. LPCAT1 correlates with the progression of prostate cancer.

12. LPCAT1 and -2 have, in addition to their known function in specialized cells, a ubiquitous role in LD-associated lipid metabolism

13. full LPCAT1 activity is required to achieve the levels of SatPC essential for the transition to air breathing

14. hLPCAT1 is the biosynthetic enzyme of pulmonary surfactant phospholipids.

15. Aytl2 gene is the phosphatidylcholine reacylating enzyme in RBCs; this represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein

16. LPCAT1 may contribute to total choline metabolite accumulation via phosphatidylcholine remodeling, thereby altering the CRC lipid profile, a characteristic of malignancy.

Mouse (Murine) Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) interaction partners

1. These results provide insight into understanding of the retinal degeneration seen in rd11 mice that lack LPCAT1.

2. LPCAT1 interacts with StarD10 and that amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction.

3. Almost wild-type LPCAT1 expression in photoreceptors with strong rod rhodopsin and M/S cone opsin staining, and normal visually-guided water maze behavioral performances were observed in treated rd11 mice.

4. Residue Cys-211 of the conserved motif III is not essential for catalysis and not sufficient for sensitivity to treatment by sulfhydryl-modifier agents.

5. evidence of a protein substrate for Lpcat1 and reveal that histone lipidation may occur through its O-palmitoylation as a novel post-translational modification.

6. LPS appears to destabilize the LPCAT1 protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination.

7. Studies add another dimension to an essential role for LPCAT1 in retinal photoreceptor homeostasis.

8. full LPCAT1 activity is required to achieve the levels of SatPC essential for the transition to air breathing

9. acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1) is predominantly expressed in the lung, in particular in alveolar type II cells.

10. Results suggest that lysophosphatidylcholine acyltransferase (LPCAT) plays a critical role in regulating surfactant phospholipid biosynthesis.

11. Aytl2 gene is the phosphatidylcholine reacylating enzyme in RBCs; this represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein

12. LPCAT1 transfers acetate from acetyl-CoA to lyso-PAF; its activity and expression are independent of inflammatory signals

13. Platelet activating factor (PAF) accumulation in spinal cord during experimental allergic encephalomyelitis depends upon up-regulation of activities of both group IV(A) cytosolic phospholipase A2 and acetyl-CoA:lyso-PAF acetyltransferase.

14. LPCAT1 plays an important role in the inactivation of PAF by catalyzing the synthesis of alkyl-PC, an inactivated form of PAF with the use of acyl-CoA and lyso-PAF as substrates.