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LPCAT2 encodes a member of the lysophospholipid acyltransferase family. Additionally we are shipping LPCAT2 Antibodies (44) and LPCAT2 Proteins (7) and many more products for this protein.
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three of these five genes (CXCL14 (show CXCL14 ELISA Kits), ITGAX (show ITGAX ELISA Kits), and LPCAT2) harbored polymorphisms associated with aggressive disease development in a human GWAS cohort consisting of 1,172 prostate cancer patients.
Data indicate a strong negative correlation between ALOX15 (show ALOX15 ELISA Kits), FADS2 (show FADS2 ELISA Kits), and IL5RA (show IL5RA ELISA Kits) expression with 2-arachidonoylglycerophosphocholine levels in dual asthmatic responses.
LPCAT1 (show LPCAT1 ELISA Kits) and -2 have, in addition to their known function in specialized cells, a ubiquitous role in LD-associated lipid metabolism
Our enzymatic assays strongly suggest that the cDNA previously identified as LPCAT2/lyso platelet-activating factor-acetyltransferase cDNA has AGPAT activity and thus we prefer to identify this clone as AGPAT11 as well.
The enzyme acetyl-CoA:LYSO-PAF acetyltransferase catalyzes not only biosynthesis of PAF upon acute inflammatory stimula (show KIAA0101 ELISA Kits)tion but also (show KIAA0101 ELISA Kits)incorporation of arachidonoyl-CoA to produce PAF precursor (show KIAA0101 ELISA Kits) membrane glycerophospholipids for membrane biogenesis.
Selected compounds competed with acetyl-CoA (show LPCAT1 ELISA Kits) for the inhibition of LPCAT2 lyso-PAFAT activity and suppressed PAF (show KIAA0101 ELISA Kits) biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore. These compounds had low inhibitory effects on LPCAT1 (show LPCAT1 ELISA Kits) activity, indicating that adverse effects on respiratory functions may be avoided.
LPCAT2 was detected in wild-type spinal cord microglia, and the absence of LPCAT2 expression precluded spinal platelet-activating factor expression in LPCAT2-knockout mice.
We show a new signaling pathway for rapid biosynthesis of PAF (show KIAA0101 ELISA Kits) that is mediated by phosphorylation of LPCAT2 at Ser (show SIGLEC1 ELISA Kits)-34.
Specific inhibition of the PAF (show KIAA0101 ELISA Kits) biosynthetic activity by phosphorylated LPCAT2 will provide a novel target for the regulation of inflammatory disorders.
Cloned the mouse acetyl-CoA:LYSO-PAF acetyltransferase (show LPCAT1 ELISA Kits) and found that the enzyme catalyzed not only biosynthesis of PAF (show KIAA0101 ELISA Kits) from lyso-PAF (show KIAA0101 ELISA Kits) but also incorporation of arachidonoyl-CoA to produce PAF (show KIAA0101 ELISA Kits) precursor membrane glycerophospholipids.
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi.
, 1-alkylglycerophosphocholine O-acetyltransferase
, LPC acyltransferase 2
, acetyl-CoA:lyso-PAF acetyltransferase
, acetyl-CoA:lyso-platelet-activating factor acetyltransferase
, acyl-CoA:lysophosphatidylcholine acyltransferase 2
, acyltransferase like 1
, acyltransferase-like 1
, lyso-PAF acetyltransferase
, lyso-platelet-activating factor (PAF) acetyltransferase
, lysoPC acyltransferase 2
, acyl-CoA:lysophosphatidylcholine acyltransferase member 1
, acyltransferase like 1A
, lysophosphatidylcholine acyltransferase 2
, Lysophosphatidylcholine acyltransferase 2
, acyltransferase-like 1-A