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LAPTM5 encodes a transmembrane receptor that is associated with lysosomes. Additionally we are shipping LAPTM5 Antibodies (25) and many more products for this protein.
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These findings suggest that the inactivation of LAPTM5 may contribute to tumorigenesis in a subset of human cancers
Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 (show CRK Proteins) in BCa (show BLNK Proteins) cells
Insufficient expression of LAPTM5 may take part in the pathogenesis of systemic lupus erythematosus (SLE) and contribute to the severity of the disease, none of LAPTM5 polymorphisms contributes significantly to SLE susceptibility in a Chinese population.
The interaction of LAPTM5 with CD1e (show CD1e Proteins) and their colocalization in antigen processing compartments both suggest that LAPTM5 might influence the role of CD1e (show CD1e Proteins) in the presentation of lipid antigens.
LAPTM5 is a substrate of the ITCH-mediated degradation and its protein level is negatively regulated by ITCH
LAPTM5-mediated programmed cell death is closely associated with the spontaneous regression of neuroblastomas
LAPTM5 shows stage-specific expression during B cell differentiation. It may be involved in B cell malignancies.
these results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling.
the pre-BCR (show BCR Proteins) induces the downmodulation of its own expression through induction of LAPTM5, which promotes the lysosomal transport and degradation of the intracellular pre-BCR (show BCR Proteins) pool and limits the supply of pre-BCR (show BCR Proteins) to the cell surface
LAPTM5 acts as a positive modulator of inflammatory signaling pathways and hence cytokine secretion in macrophages
LAPTM5 physically interacts with the B cell receptor complex and promotes its degradation in the lysosomal compartment in mouse B cells.
the lysosomal protein LAPTM5 negatively regulated surface TCR expression by specifically interacting with the invariant signal-transducing CD3zeta chain (show CD247 Proteins) and promoting its degradation
This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis.
lysosomal protein transmembrane 5
, CD40-ligand-activated specific transcripts
, human retinoic acid-inducible E3 protein
, lysosomal associated multispanning membrane protein 5
, lysosomal multispanning membrane protein 5
, lysosomal-associated multitransmembrane protein 5
, lysosomal-associated transmembrane protein 5
, retinoic acid-inducible E3 protein
, lysosomal-associated multispanning membrane protein 5