anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) Antibodies

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate.

list all antibodies Gene Name GeneID UniProt
Anti-Human MAD2L1 MAD2L1 4085 Q13257
Anti-Mouse MAD2L1 MAD2L1 56150 Q9Z1B5
Anti-Rat MAD2L1 MAD2L1 297176  
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Top anti-MAD2L1 Antibodies at antibodies-online.com

Showing 10 out of 142 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP Detection of human MAD2 by Western Blot and Immunoprecipitation. Samples: NETN whole cell lysate (50 ug for WB, 600 ug for IP) from HeLa cells. Antibodies: ABIN151995 used at 1 ug/ml for WB (A) and at 0.7 ug/mg lysate for IP (B). MAD2 was also immunoprecipitated using rabbit anti-MAD2 antibody ABIN151996 at 0.7 ug/mg lysate. Immunoprecipitated MAD2 was blotted using ABIN151996 at 0.2 ug/ml. Detection: Chemiluminescence with an exposure time of 1 minute (A and B). Immunohistochemistry-Paraffin: MAD2L1 Antibody [ABIN151995] - Section of human lung carcinoma. 100 μL Log in to see 7 to 9 Days
$556.31
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MAD2L1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB IHC-P Image MAD2L1 antibody [C2C3], C-term detects MAD2L1 protein at cytoplasm and nucleus in human A549 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded human A549 xenograft. MAD2L1 antibody [C2C3], C-term , diluted at 1:250. WB Image Sample (30μg whole cell lysate) A:Hep G2 , B:MOLT4 , C:Raji , 12% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated WB Anti- Mad2L1 Picoband antibody, Western blotting All lanes: Anti Mad2L1 at 0.5ug/ml Lane 1: 293T Whole Cell Lysate at 40ug Lane 2: COLO320 Whole Cell Lysate at 40ug Predicted bind size: 23KD Observed bind size: 23KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: MAD2L1 Antibody [NBP1-31311] - Paraffin-embedded DLD-1 xenograft, using antibody at 1:500 dilution. Western Blot: MAD2L1 Antibody [NBP1-31311] - A:Hep G2 B:MOLT4 C:Raji 12% SDS PAGE NBP1-31311 diluted at 1:1000 100 μL Log in to see 8 to 11 Days
$514.63
Details
Human Mouse Un-conjugated WB MAD2L1 monoclonal antibody (M01), clone 2E2-1D6 Western Blot analysis of MAD2L1 expression in HeLa. Detection limit for recombinant GST tagged MAD2L1 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Mouse Un-conjugated IHC (p), IP, WB IImmunohistochemistry of normal testis (formalin fixed) after antigen retreival, stained with Anti-Mad2L1 (clone 17D10)). Primary spermatocytes show staining of both the cytoplasm and nucleus. Picture kindly supplied by M.d.Espen Burum-Auensen from Rikshospitalet, Norway 50 μL Log in to see 7 to 8 Days
$455.57
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 8 to 11 Days
$619.30
Details
Human Rabbit Un-conjugated WB Western Blot: Mad2L1 Antibody [NBP1-33529] - Sample (30 ug of whole cell lysate) A: 293T 12% SDS PAGE; antibody diluted at 1:1000. 100 μL Log in to see 8 to 11 Days
$514.63
Details

Top referenced anti-MAD2L1 Antibodies

  1. Human Polyclonal MAD2L1 Primary Antibody for ICC, IF - ABIN151995 : Wu, Glickstein, Liu, Fujita, Li, Yang, Duvoisin, Wan: The anaphase-promoting complex coordinates initiation of lens differentiation. in Molecular biology of the cell 2007 (PubMed)
    Show all 13 Pubmed References

  2. Human Monoclonal MAD2L1 Primary Antibody for IHC (p), IP - ABIN108556 : Burum-Auensen, Deangelis, Schjølberg, Røislien, Andersen, Clausen: Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. in Journal of clinical pathology 2007 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal MAD2L1 Primary Antibody for IHC (p), IP - ABIN108555 : Gysin, Paquette, McMahon: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. in Molecular cancer research : MCR 2012 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal MAD2L1 Primary Antibody for ELISA, WB - ABIN268644 : Li, Benezra: Identification of a human mitotic checkpoint gene: hsMAD2. in Science (New York, N.Y.) 1996 (PubMed)

  5. Human Monoclonal MAD2L1 Primary Antibody for ELISA, WB - ABIN561710 : Yeh, Yeh, Chen, Juang: RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. in The Journal of biological chemistry 2012 (PubMed)

  6. Human Polyclonal MAD2L1 Primary Antibody for WB - ABIN2801908 : Gemma, Hosoya, Seike, Uematsu, Kurimoto, Hibino, Yoshimura, Shibuya, Kudoh, Emi: Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers. in Lung cancer (Amsterdam, Netherlands) 2001 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal MAD2L1 Primary Antibody for ICC, IF - ABIN441319 : Itoh, Sugino, Ikeda, Mizuguchi, Kanno, Amin, Iemura, Yasui, Hirota, Tanaka: Nucleoporin Nup188 is required for chromosome alignment in mitosis. in Cancer science 2013 (PubMed)

More Antibodies against MAD2L1 Interaction Partners

Human MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. MAD2-p31 (show ATP6V1E1 Antibodies)(comet) axis may serve as a potential therapeutic target for glioma.

  2. These results identify an unexpected dependency on TRIP13 (show TRIP13 Antibodies) in cells overexpressing Mad2.

  3. this study shows that MAD2L1 is a prognostic biomarker for lung adenocarcinoma

  4. MiR (show MLXIP Antibodies)-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma by suppressing MAD2L1 expression.

  5. Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.

  6. TRAP1 (show TRAP1 Antibodies) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (show TRAP1 Antibodies)/TBP7 (show PSMC4 Antibodies) quality control of CDK1 (show CDK1 Antibodies) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.

  7. Thes authors show that p31 (show ATP6V1E1 Antibodies)(comet) binding to the TRIP13 (show TRIP13 Antibodies) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (show TRIP13 Antibodies) "pore loops", which then unfold MAD2 in the presence of ATP.

  8. catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (show BUB3 Antibodies) complex assembly

  9. in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (show AURKB Antibodies).

  10. Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (show BGN Antibodies)-DLBCL. Mad2 overexpression indicated a poor DFS (show FST Antibodies).

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. Mad2 (show MXI1 Antibodies)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.

  2. reduced MAD2 (show MXI1 Antibodies) levels attenuate the apoptotic response to mis (show AMH Antibodies)-segregating sex chromosomes and allow the formation of aneuploid sperm.

  3. p31comet-induced cell death is mediated by interactions with Mad2 (show MXI1 Antibodies)

  4. study shows that Mad2 (show MXI1 Antibodies) is a novel substrate for CCP6 (show AGBL4 Antibodies) in megakaryocytes; Mad2 (show MXI1 Antibodies) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis

  5. Exacerbating chromosome missegregation in CENP-E (show CENPE Antibodies)+/- mice by reducing levels of another mitotic checkpoint component (show BUB3 Antibodies), Mad2 (show MXI1 Antibodies), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.

  6. Mad2 (show MXI1 Antibodies) is also repressed by p53 (show TP53 Antibodies) and its upregulation is required for chromosome instability in a p53 (show TP53 Antibodies) mutant tumor model

  7. Data show that Mad2 (show MXI1 Antibodies) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (show APEX1 Antibodies) inhibitor in vitro.

  8. Pcid2 (show PCID2 Antibodies) is essential for B cell survival through the regulation of MAD2 (show MXI1 Antibodies) expression during B cell differentiation

  9. tumours that experience transient Mad2 (show MXI1 Antibodies) overexpression and consequent chromosome instability recur at markedly elevated rates

  10. a functional Mad2 (show MXI1 Antibodies)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes

MAD2L1 Antigen Profile

Protein Summary

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

Gene names and symbols associated with MAD2L1

  • mitotic arrest deficient 2 like 1 (MAD2L1) antibody
  • MAD2 mitotic arrest deficient-like 1 (Mad2l1) antibody
  • MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1) antibody
  • MAD2 mitotic arrest deficient-like 1 (yeast) (mad2l1) antibody
  • mitotic arrest deficient 2 like 1 (mad2l1) antibody
  • mitotic arrest deficient 2 like 1 (Mad2l1) antibody
  • mitotic arrest deficient 2 like 1 S homeolog (mad2l1.S) antibody
  • AA673185 antibody
  • cb408 antibody
  • HSMAD2 antibody
  • mad2 antibody
  • MAD2L1 antibody
  • XMad2 antibody
  • zgc:112133 antibody

Protein level used designations for MAD2L1

MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 , MAD2-like protein 1 , mitotic arrest deficient 2-like protein 1 , mitotic arrest deficient, yeast, homolog-like 1 , mitotic spindle assembly checkpoint protein MAD2A , MAD2 (mitotic arrest deficient, homolog)-like 1 , MAD2-like 1 , spindle assembly checkpoint protein Mad2 , MAD2 mitotic arrest deficient-like 1 , MAD2 mitotic arrest deficient-like 1 (yeast)

GENE ID SPECIES
4085 Homo sapiens
56150 Mus musculus
337870 Bos taurus
422675 Gallus gallus
461661 Pan troglodytes
476070 Canis lupus familiaris
550434 Danio rerio
708574 Macaca mulatta
100125170 Xenopus (Silurana) tropicalis
100137358 Papio anubis
100218172 Taeniopygia guttata
297176 Rattus norvegicus
380433 Xenopus laevis
100731050 Cavia porcellus
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