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MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate.
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Human Polyclonal MAD2L1 Primary Antibody for ICC, IF - ABIN151995
Wu, Glickstein, Liu, Fujita, Li, Yang, Duvoisin, Wan: The anaphase-promoting complex coordinates initiation of lens differentiation. in Molecular biology of the cell 2007
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Human Monoclonal MAD2L1 Primary Antibody for IHC (p), IP - ABIN108556
Burum-Auensen, Deangelis, Schjølberg, Røislien, Andersen, Clausen: Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. in Journal of clinical pathology 2007
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Human Monoclonal MAD2L1 Primary Antibody for IHC (p), IP - ABIN108555
Gysin, Paquette, McMahon: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. in Molecular cancer research : MCR 2012
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Human Polyclonal MAD2L1 Primary Antibody for ELISA, WB - ABIN268644
Li, Benezra: Identification of a human mitotic checkpoint gene: hsMAD2. in Science (New York, N.Y.) 1996
Human Monoclonal MAD2L1 Primary Antibody for ELISA, WB - ABIN561710
Yeh, Yeh, Chen, Juang: RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. in The Journal of biological chemistry 2012
Human Polyclonal MAD2L1 Primary Antibody for WB - ABIN2801908
Gemma, Hosoya, Seike, Uematsu, Kurimoto, Hibino, Yoshimura, Shibuya, Kudoh, Emi: Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers. in Lung cancer (Amsterdam, Netherlands) 2001
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Human Polyclonal MAD2L1 Primary Antibody for ICC, IF - ABIN441319
Itoh, Sugino, Ikeda, Mizuguchi, Kanno, Amin, Iemura, Yasui, Hirota, Tanaka: Nucleoporin Nup188 is required for chromosome alignment in mitosis. in Cancer science 2013
MAD2-p31 (show ATP6V1E1 Antibodies)(comet) axis may serve as a potential therapeutic target for glioma.
These results identify an unexpected dependency on TRIP13 (show TRIP13 Antibodies) in cells overexpressing Mad2.
this study shows that MAD2L1 is a prognostic biomarker for lung adenocarcinoma
MiR (show MLXIP Antibodies)-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma by suppressing MAD2L1 expression.
Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.
TRAP1 (show TRAP1 Antibodies) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (show TRAP1 Antibodies)/TBP7 (show PSMC4 Antibodies) quality control of CDK1 (show CDK1 Antibodies) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.
Thes authors show that p31 (show ATP6V1E1 Antibodies)(comet) binding to the TRIP13 (show TRIP13 Antibodies) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (show TRIP13 Antibodies) "pore loops", which then unfold MAD2 in the presence of ATP.
catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (show BUB3 Antibodies) complex assembly
in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (show AURKB Antibodies).
Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (show BGN Antibodies)-DLBCL. Mad2 overexpression indicated a poor DFS (show FST Antibodies).
Mad2 (show MXI1 Antibodies)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.
reduced MAD2 (show MXI1 Antibodies) levels attenuate the apoptotic response to mis (show AMH Antibodies)-segregating sex chromosomes and allow the formation of aneuploid sperm.
p31comet-induced cell death is mediated by interactions with Mad2 (show MXI1 Antibodies)
study shows that Mad2 (show MXI1 Antibodies) is a novel substrate for CCP6 (show AGBL4 Antibodies) in megakaryocytes; Mad2 (show MXI1 Antibodies) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis
Exacerbating chromosome missegregation in CENP-E (show CENPE Antibodies)+/- mice by reducing levels of another mitotic checkpoint component (show BUB3 Antibodies), Mad2 (show MXI1 Antibodies), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
Mad2 (show MXI1 Antibodies) is also repressed by p53 (show TP53 Antibodies) and its upregulation is required for chromosome instability in a p53 (show TP53 Antibodies) mutant tumor model
Data show that Mad2 (show MXI1 Antibodies) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (show APEX1 Antibodies) inhibitor in vitro.
Pcid2 (show PCID2 Antibodies) is essential for B cell survival through the regulation of MAD2 (show MXI1 Antibodies) expression during B cell differentiation
tumours that experience transient Mad2 (show MXI1 Antibodies) overexpression and consequent chromosome instability recur at markedly elevated rates
a functional Mad2 (show MXI1 Antibodies)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
, MAD2-like protein 1
, mitotic arrest deficient 2-like protein 1
, mitotic arrest deficient, yeast, homolog-like 1
, mitotic spindle assembly checkpoint protein MAD2A
, MAD2 (mitotic arrest deficient, homolog)-like 1
, MAD2-like 1
, spindle assembly checkpoint protein Mad2
, MAD2 mitotic arrest deficient-like 1
, MAD2 mitotic arrest deficient-like 1 (yeast)