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MXD1 encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. Additionally we are shipping MXD1 Antibodies (49) and MXD1 Proteins (6) and many more products for this protein.
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Results suggest a role for MAX dimerization protein 1 (MXD1) in the control of ribosome biogenesis.
Study revealed that HIF-1alpha (show HIF1A ELISA Kits)-induced Mxd1 contributes to cisplatin-resistance in hypoxic osteosarcoma cells by directly repressing PTEN, which leads to the activation of PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) antiapoptotic and survival pathway.
the miR (show MLXIP ELISA Kits)-382-5p/MXD1 axis plays a critical role in myelopoiesis by affecting the lineage choice of CD34 (show CD34 ELISA Kits)(+) hematopoietic stem/progenitor cells.
TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression.
down regulation of miR (show MLXIP ELISA Kits)-202 increased the expression of its target Mxd1, followed by Mxd1 recruitment to the Sin3A (show SIN3A ELISA Kits) repressor complex and through its dimerization with Max, and increased repression of Myc (show MYC ELISA Kits)-Max target proteins.
miR-17-92 cluster members miR (show MLXIP ELISA Kits)-19a/b facilitated gastric cancer cell migration, invasion and metastasis through targeting the antagonist of c-Myc (show MYC ELISA Kits) -- MXD1.
This study suggests that genetic variants of MXD1 may modulate the effect of smoking on carotid plaque burden.
Mad1 gene transfer inhibits the proliferation of human melanoma cells
HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations
MAD1 and Proto-Oncogene (show RAB1A ELISA Kits) Proteins c-myc (show MYC ELISA Kits) reciprocally regulate ribosomal DNA transcription, providing a mechanism for coordination of ribosome biogenesis and cell growth
1,25D and the VDR (show CYP27B1 ELISA Kits) regulate the c-MYC (show MYC ELISA Kits)/MXD1 network to suppress c-MYC (show MYC ELISA Kits) function, providing a molecular basis for cancer preventive actions of vitamin D.
Phe-7 is the critical determinant and provides the molecular specificity for the association between Sin3 and Mad in regulating cell growth and differentiation.
Mad1 is a transcriptional repressor of Bcl-6 (show BCL6 ELISA Kits).
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
MAX dimerization protein 1
, MAD protein
, max dimerization protein 1
, max dimerizer 1
, MAX-binding protein
, antagonizer of myc transcriptional activity