anti-MKL/myocardin-Like 2 (MKL2) Antibodies

Acts as a transcriptional coactivator of serum response factor (SRF). Additionally we are shipping MKL2 Kits (4) and MKL2 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MKL2 57496 Q9ULH7
MKL2 100362470  
MKL2 239719 P59759
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Top anti-MKL2 Antibodies at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: RGD1560833 Sample Type: Rat Pancreas lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of MKL2 expression in HEK293T (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of MKL2 Antibody (N-term) in mouse bladder tissue lysates (35ug/lane). This demonstrates the MKL2 antibody detected the MKL2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Mouse Rabbit Un-conjugated WB MKL2 Antibody (N-term) (ABIN656903) western blot analysis in mouse bladder tissue lysates (35 µg/lane). This demonstrates the MKL2 antibody detected the MKL2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of MKL2 using HuvEc whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 11 to 13 Days
$335.04
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 11 to 14 Days
$375.83
Details
Mouse Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$658.43
Details
Mouse Rabbit HRP ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,101.83
Details
Mouse Rabbit FITC ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,101.83
Details

Top referenced anti-MKL2 Antibodies

  1. Human Polyclonal MKL2 Primary Antibody for ICC, IF - ABIN4334830 : Seifert, Posern: Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini. in Breast cancer research : BCR 2017 (PubMed)

More Antibodies against MKL2 Interaction Partners

Human MKL/myocardin-Like 2 (MKL2) interaction partners

  1. Our new data identifies and important contribution of MKL1/2 to explaining the strikingly different response of VSMCs and ECs to cAMP elevation. Elucidation of these pathways promises to identify targets for specific inhibition of VSMC migration and proliferation.

  2. Taken together, these findings suggest that MKL1 and MKL2 are present at synapses and involved in dendritic spine maturation.

  3. Study showed that MRTF-A and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer.

  4. While disruption of the MKL2:SRF axis has been associated with severe microcephaly and disordered brain development in multiple model systems, the role of this transcription factor complex has not been previously demonstrated in human brain development.

  5. There were multiple independent HIV integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells.

  6. MKL1/2 depletion resulted in Ras activation, elevated p16 expression and hypophosphorylation of the retinoblastoma (Rb) protein in DLC1-deficient hepatocellular carcinoma cells.

  7. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas.

  8. study provides evidence that MKL1/2 mediates cancerous transformation in DLC1-deficient hepatocellular and mammary carcinoma cells

  9. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma.

  10. dominant negative MKL2 blocked differentiation-induced expression of SRF target genes skeletal alpha-actin and alpha-myosin heavy chain and blocked differentiation of the myoblasts to myotubes in vitro.

  11. BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases.

  12. Myocardin-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[

  13. RNA interference was used to investigate the contribution of the MRTF-SRF pathway to cytoskeletal dynamics in MDA-MB-231 breast carcinoma and B16F2 melanoma cells, in which basal MRTF-SRF activity is Rho-dependent.

Mouse (Murine) MKL/myocardin-Like 2 (MKL2) interaction partners

  1. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  2. MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 and interactions between HAoECs and leukocytes

  3. Either MRTF-A or MRTF-B is dispensable for cardiac development, whereas deletion of both causes a spectrum of abnormalities ranging from reduced cardiac contractility and adult onset heart failure to neonatal lethality accompanied by sarcomere disarray.

  4. These results identify SRF and its MRTF cofactors as major transcriptional regulators of endothelial cell junctional stability, guaranteeing physiological functions of the cerebral microvasculature.

  5. Suggest role for nuclear RhoA signaling in MRTF-dependent gene expression in smooth muscle cells.

  6. Myocardin-related transcription factor (MRTF)-A and MRTF-B (MKL1 and MKL2, respectively) are enriched in the perinuclear space of epicardial cells during development.

  7. MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.

  8. Smad2 interaction with MRTFB seems to be a novel and important mechanism underlying neural crest cell differentiation to vascular smooth muscle cells.

  9. MRTF-B knockdown leads to increase in S and G2/M populations and downregulation of cyclin-CDK inhibitors p27Kip1, p18Ink4c and 19Ink4d as well as upregulation of p21Waf1 and cyclin D1.

  10. Data suggest that MKL1 and MKL2 are expressed in megakaryocytes and platelets; megakaryocytes lacking expression of MKL1 and/or MKL2 have both defective megakaryocytopoiesis and thrombopoiesis.

  11. MKL2 regulates a conserved TGF-beta signaling pathway that is required for angiogenesis and ultimately embryonic survival.

  12. show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B and the signaling factor Fgf10

  13. MRTF-A/B are potent repressors of cancer progression and metastasis and may be good targets for cancer therapy.

  14. MRTF-B plays a critical role in regulating differentiation of cardiac neural crest cells into smooth muscle.

  15. interacts with serum response factor and stimulates its transcriptional activity

  16. Data show that mice homozygous for a myocardin-related transcription factor-B loss-of-function mutation die during mid-gestation from a spectrum of cardiovascular defects.

  17. MRTF-B has a unique role in regulating smooth muscle genes important for liver, yolk sac, and portal vascular development.

  18. This review focuses on the role MRTF-B plays in regulating cardiovascular patterning, vascular smooth muscle cell and cardiomyocyte differentiation, and in the pathogenesis of congenital heart disease and vascular proliferative syndromes.

  19. These results indicate that MRTF-A/B act as pivotal mediators of stress fiber and focal adhesion formation via the transcriptional regulation of a subset of cytoskeletal/focal adhesion genes.

MKL2 Antigen Profile

Protein Summary

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.

Gene names and symbols associated with MKL2

  • MKL1/myocardin like 2 (MKL2) antibody
  • MKL1/myocardin like 2 S homeolog (mkl2.S) antibody
  • MKL1/myocardin like 2 (mkl2) antibody
  • MKL1/myocardin like 2 (Mkl2) antibody
  • MKL/myocardin-like 2 (Mkl2) antibody
  • ENSMUSG00000075401 antibody
  • Gt4-1 antibody
  • MGC145857 antibody
  • mKIAA1243 antibody
  • MRTF-B antibody
  • mrtf-b-A antibody
  • Mrtfb antibody
  • npd001 antibody

Protein level used designations for MKL2

MKL/myocardin-like protein 2 , megakaryoblastic leukemia 2 , myocardin-related transcription factor B , MRTF-B , xMRTF-B , MKL/myocardin-like 2 , megakaryoblastic leukemia 2 protein , gene trap insertion site 4-1

GENE ID SPECIES
57496 Homo sapiens
378496 Xenopus laevis
780107 Xenopus (Silurana) tropicalis
100050736 Equus caballus
100073360 Ornithorhynchus anatinus
100350900 Oryctolagus cuniculus
100362470 Rattus norvegicus
239719 Mus musculus
100731881 Cavia porcellus
511461 Bos taurus
416421 Gallus gallus
489999 Canis lupus familiaris
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