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The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis.
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In-depth IPA analysis revealed that CENPU was associated with the HMGB1 (show HMGB1 ELISA Kits) signaling pathway. qPCR and western blot analysis demonstrated that in the HMGB1 (show HMGB1 ELISA Kits) signaling pathway, CENPU knockdown downregulated expression levels of ILB, CXCL8 (show IL8 ELISA Kits), RAC1 and IL1A (show IL1A ELISA Kits)
This study provides new insights and evidences that MLF1IP over-expression plays important roles in progression of luminal breast cancer. However, the precise cellular mechanisms for MLF1IP in luminal breast cancer need to be further explored.
MLF1IP promotes normal erythroid proliferation and (show IGF2BP3 ELISA Kits) is involved in the pathogenesis of polycythemia vera.
MLF1IP significantly promotes prostate cancer cell proliferation and colony formation and significantly inhibits apoptosis without affecting cell cycle phase arrest in prostate cancer cell lines
Plk1 (show PLK1 ELISA Kits) regulates the timing of the delocalization and ultimate destruction of the PBIP1.CENP-Q (show CENPQ ELISA Kits) complex.
Data propose that CENP-P (show CENPP ELISA Kits)/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step that could be important for kinetochores switching into the correct conformation for microtubule-attachment.
Mammalian polo-like kinase 1 (show PLK1 ELISA Kits)-dependent regulation of the PBIP1-CENP-Q (show CENPQ ELISA Kits) complex at kinetochores.
CENP-U is a novel microtubule binding protein and plays an important role in kinetochore-microtubule attachment through its interaction with Hec1
a possible role for MLF1IP deregulation in the genesis of erythroleukemias
MLF1IP was found in glioblastomas where it was co-localized with MLF1 (show MLF1 ELISA Kits) and nestin (show NES ELISA Kits). Moreover, it was elevated in the contralateral brain where no tumor cells occurred, suggesting a role in glioma pathogenesis and potentially in other types of malignancies.
MLF1IP transgenic mice developed polycythemia vera (show IGF2BP3 ELISA Kits) (PV)-like symptoms based on the analysis of hematological features, suggesting that MLF1IP is partially involved in the pathogenesis of PV.
MLF1 (show MLF1 ELISA Kits)-IP expression at about 50% of its normal level is sufficient to sustain mice life and the development of their immune system without apparent abnormalities.
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006
MLF1 interacting protein
, centromere protein U-like
, KSHV latent nuclear antigen interacting protein 1
, KSHV latent nuclear antigen-interacting protein 1
, MLF1-interacting protein
, centromere protein U
, centromere protein of 50 kDa
, interphase centromere complex protein 24
, polo-box-interacting protein 1
, myeloid leukemia factor 1 interacting protein
, centromere protein p50