MLX Interacting Protein Proteins (MLXIP)

MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000 [PubMed 11073985]).[supplied by OMIM, Mar 2008].. Additionally we are shipping MLX Interacting Protein Antibodies (37) and MLX Interacting Protein Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MLXIP 22877 Q9HAP2
MLXIP 208104 Q2VPU4
Rat MLXIP MLXIP 304479  
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Top MLX Interacting Protein Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details

MLXIP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for MLX Interacting Protein (MLXIP) Interaction Partners

Human MLX Interacting Protein (MLXIP) interaction partners

  1. Data (including data from studies in knockout mice) suggest that MONDOA shuttles to nucleus of pancreatic beta-cells where it is required for induction of glucose-responsive genes arrestin domain-containing protein 4 (ARRDC4) and thioredoxin interacting protein (TXNIP).

  2. MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin signaling

  3. Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism.

  4. These results suggest that C771G polymorphism of MLXIPL gene is associated with coronary stenosis and its severity.

  5. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in apoptosis

  6. regulatory relationship between mTOR and the MondoA-TXNIP axis that we propose contributes to glucose homeostasis

  7. Suppression of Txnip by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei.

  8. An important contribution of MondoA to leukemia aggressiveness, which makes MondoA a potential candidate for targeted treatment of acute lymphoblastic leukemia.

  9. the MondoA-TXNIP regulatory circuit has a role in the hexose transport curb, although other redundant pathways also contribute

  10. Induction of TXNIP under lactic acidosis is caused by the activation of the glucose-sensing helix-loop-helix transcriptional complex MondoA:Mlx, which is usually triggered upon glucose exposure.

  11. Glucose is required at two additional steps to stimulate the transcription activation function of MondoA-Mlx complexes.

  12. Data show that for both MondoA and Mlx, the C-terminal domain CRM-1 has cytoplasmic localization activity that is required by the protein monomers to accumulate in the cytoplasm.

  13. Endogenous MondoA and Mlx associate with mitochondria in primary skeletal muscle.

  14. These studies suggest a key role for MondoA:Mlx complexes in the adaptive transcriptional response to changes in extracellular glucose concentration and peripheral glucose uptake.

  15. Data suggest that glutamine-dependent mitochondrial anapleurosis dictates glucose uptake and aerobic glycolysis by blocking MondoA:Mlx-dependent transcriptional activation of TXNIP.

Mouse (Murine) MLX Interacting Protein (MLXIP) interaction partners

  1. Data (including data from studies in knockout mice) suggest that MondoA shuttles to nucleus of pancreatic beta-cells where it is required for induction of glucose-responsive genes arrestin domain-containing protein 4 (Arrdc4) and thioredoxin interacting protein (Txnip).

  2. MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin signaling

  3. Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism.

  4. MondoA is a basic helix-loop-helix/leucine zipper transcription factor that is expressed predominantly in skeletal muscle. Mice deficient for MondoA excel in sprinting, as their skeletal muscles display an enhanced glycolytic capacity.

  5. MondoA-Mlx complexes sense elevated levels of G6P and adenine nucleotides to trigger a TXNIP-dependent feedback inhibition of glycolysis

  6. Suppression of Txnip by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei.

  7. the MondoA-TXNIP regulatory circuit has a role in the hexose transport curb, although other redundant pathways also contribute

  8. Induction of TXNIP under lactic acidosis is caused by the activation of the glucose-sensing helix-loop-helix transcriptional complex MondoA:Mlx, which is usually triggered upon glucose exposure.

MLX Interacting Protein (MLXIP) Protein Profile

Protein Summary

MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000

Gene names and symbols associated with MLXIP

  • MLX interacting protein (MLXIP)
  • MLX interacting protein L homeolog (mlxip.L)
  • MLX interacting protein (mlxip)
  • MLX interacting protein (Mlxip)
  • AW228700 protein
  • B930074I24 protein
  • bHLHe36 protein
  • MGC83884 protein
  • Mir protein
  • mKIAA0867 protein
  • MONDOA protein
  • RGD1560774 protein
  • si:ch211-110p13.4 protein

Protein level used designations for MLXIP

MLX interacting protein , MondoA-like , MLX-interacting protein-like , MLX-interacting protein , Mlx interactor , MondoA , class E basic helix-loop-helix protein 36 , transcriptional activator MondoA

GENE ID SPECIES
416857 Gallus gallus
431799 Xenopus laevis
452323 Pan troglodytes
705874 Macaca mulatta
783217 Bos taurus
798052 Danio rerio
100021969 Monodelphis domestica
100036655 Xenopus (Silurana) tropicalis
100060001 Equus caballus
100156510 Sus scrofa
100344781 Oryctolagus cuniculus
100439640 Pongo abelii
100558305 Anolis carolinensis
22877 Homo sapiens
208104 Mus musculus
304479 Rattus norvegicus
477464 Canis lupus familiaris
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