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Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Additionally we are shipping MAEL Kits (6) and MAEL Proteins (6) and many more products for this protein.
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Report found that Mael is activated in proliferating cancer cells, where it serves to maintain genetic stability. Its depletion results in an increase in reactive oxygen species, followed by apoptosis or senescence.
Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR (show MLXIP Antibodies)-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1 (show MTSS1 Antibodies).
Study demonstrated that MAEL interacts with Snail (show SNAI1 Antibodies) and inhibit E-cadherin (show CDH1 Antibodies) promoter activity. MAEL is an oncogene (show RAB1A Antibodies) that plays an important role in the development and progression of colon cancer.
Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 (show PABPC1 Antibodies) in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs (show FBN1 Antibodies).
Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt (show AKT1 Antibodies)/GSK-3beta/Snail (show SNAI1 Antibodies) signaling.
These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation (show HELLS Antibodies).
MAEL HMG (show SSRP1 Antibodies)-box domain may contribute to MAEL function in selective processing of retrotransposon RNA into piRNAs.
an important role for Mael in early oogenesis and during germ-cell differentiation from embryonic stem cells
This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs (show TES Antibodies)) and identifies the initiation of meiosis as an important step in (TE) control in the male germline.
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).
cancer/testis antigen 128
, maelstrom homolog
, protein maelstrom homolog
, spermatogenesis associated 35