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Plays a role in thermogenesis via beta-adrenergic signaling pathway.
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In offspring of women with gestational diabetes mellitus treated either with diet or insulin (show INS ELISA Kits), higher fetal fat accretion and lower placental MFSD2a contribute to reduce docosahexaenoic acid availability.
Levels of DHA-derived epoxides are lower in colon tissues from patients with ulcerative colitis than healthy and resolving mucosa. Production of these metabolites by gut endothelium requires MFSD2A; endothelial progenitor cells that overexpress MFSD2A reduce colitis in mice.
The regulatory role of Mfsd2a deepens our knowledge of the function of the BBB (show ALMS1 ELISA Kits), potentially contributing to the effective drug delivery in the treatments for neurodegenerative diseases, brain tumors, and life-threatening infections in the CNS
MFSD2A transported structurally related acylcarnitines but not a lysolipid without a negative charge, demonstrating the necessity of a negatively charged headgroup interaction with Lys (show LYZ ELISA Kits)-436 for transport.
A homozygous mutation affecting a highly conserved MFSD2A residue (p.Ser339Leu) is associated with a progressive microcephaly syndrome characterized by intellectual disability, spasticity and absent speech.
MFSD2A mutations impair brain lipid transport activity.
Several tagging SNPs and haplotypes in TRIT1, MYCL1 and MFSD2A region are significantly associated with risk and clinicopathological features of gastric cancer in a Chinese population.
Importance of MFSD2a in trophoblast fusion and placenta development.
SNP rs12072037 modulates MFSD2A promoter activity and thus might affect MFSD2A levels in normal lung and in lung tumors.
MFSD2A is a putative Tunicamycin transporter at the plasma membrane.
Mfsd2a may protect against BBB (show ALMS1 ELISA Kits) injury by inhibiting vesicular transcytosis following intracerebral hemorrhage.
Transplantation of endothelial progenitor cells that overexpress MFSD2A reduce colitis in mice.
Maternal DHA supplementation had a strong impact on offspring hepatic gene expression, especially of the fatty acid transporter, Mfsd2a, suggesting a dynamic interplay between DHA synthesis and DHA uptake in the control of systemic levels in the offspring
Mfsd2a lipid transport function is required for suppression of transcytosis and blood brain barrier integrity.
These findings identify LPC transport via Mfsd2a as an important pathway for DHA uptake in eye and for development of photoreceptor membrane discs.
findings identify Mfsd2a as a key regulator of blood brain barrier function that may act by suppressing transcytosis in CNS endothelial cells.
identification of a member of the major facilitator superfamily--Mfsd2a (previously an orphan transporter)--as the major transporter for docosahexaenoic acid uptake into brain
Data suggest that the ligand(s) that are transported by MFSD2A play important roles in these physiological processes and await future identification.
Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis.
Plays a role in thermogenesis via beta-adrenergic signaling pathway. May be the main plasma membrane tunicamycin transporter.
major facilitator superfamily domain containing 2
, major facilitator superfamily domain containing 2A
, major facilitator superfamily domain-containing protein 2A