Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) ELISA Kits

Human Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. miR-675-5' induces expression of MMP1 and MMP13.

2. MMP1-PAR1 signaling system drives chronic inflammatory signaling in plaques and the progression of atherosclerosis.

3. Hepatitis C virus/Hepatitis B Virus co-infected patients with significant fibrosis did not show any significant difference (P > 0.05) from HCV mono-infected patients with respect to HCV-NS4, collagen III and MMP-1.

4. The present study also revealed MMP-1-positive Hepatic progenitor cell in the early stages of nonalcoholic steatohepatitis.

5. A TGFb1 inhibitor was also applied, which attenuated the effects of mechanical force on Human gingival fibroblasts (HGF) proliferation, and COL1 and MMP1 expression, thus suggesting that TGFb signaling pathways may mediate the mechanical forceinduced alterations observed in HGFs.

6. The odonto/osteogenic differentiation ability of stem cells from apical papilla (SCAPs) ascended after repression of hsa-let-7b, which was then reversed after co-transfection with siMMP1. Together, hsa-let-7b can suppress the odonto/osteogenic differentiation capacity of SCAPs by targeting MMP1.

7. this case-control study confirms that MMP-1 gene rs1799750 polymorphism increases the risk of knee osteoarthritis in Chinese Han population.

8. Study revealed that MMP1-1607 (1G>2G) polymorphism was significantly associated with elevated risk of cancers. [meta-analysis]

9. cFos bound to the AP-1 cis element within the proximal MMP1 promoter only when the gene was transcriptionally silent as previously observed for MMP13. cFos contributes to MMP1 expression. Silencing of ATF3 (a prime MMP13 modulator) did not affect MMP1 expression whilst silencing CSRNP1 resulted in substantial repression of MMP1 but not MMP13.

10. activation of MMP-1 depends on increased plasmin activity

11. Pax-7 was highly expressed in MG-63(MMP-1+) cells.

12. A significant association of rs1799750 (MMP-1) and rs11225395 (MMP-8) polymorphism on early implant loss was demonstrated (P

13. MMP1 rs1799750 1G/2G genotype was found to play a significant role in the development of exudative AMD at the age of less than 65 years. IL-1beta concentration was significantly higher in exudative AMD patients for MMP1 rs1799750 1G/1G genotype and MMP7 rs11568818 A/G genotype compared with control group subjects.

14. Based on bioinformatic analysis, MMP1 and FHL1 are potentially functional proteins associated with differences of highly-metastatic prostate cancer PC-3M-1E8 cell line and poorly-metastatic PC-3M-2B4 cell line. In addition, functional analyses demonstrated that silencing MMP1 remarkably weakened the in vitro migratory and invasive capabilities of the PC-3M-1E8 cells.

15. We observed significantly higher levels of IL-6 and MMP1 at the early time points (day one, two, and four) following trabeculectomy, and the protein amounts went back to the level observed before the surgery three months after the intervention

16. Inexpensive high throughput purification of recombinant human MMP1 in E. coli will enable easier MMP1 production for diverse applications.

17. Here the authors describe the identification of gamma-activated site (GAS)-like, signal transducer and activator of transcription (STAT) binding elements (SBEs) within the proximal promoters of the MMP-1 and MMP-3 genes, which bind STAT-1 in a homodimer like complex (HDLC). They further demonstrate that MMP expression and binding of this complex to SBEs can be enhanced by interleukin (IL)-6.

18. High MMP1 expression is associated with severe degenerative disc.

19. MMP-1 and MMP-8 gene polymorphisms have a role in promoting the increase and remodeling of the collagen III and V in posterior tibial tendinopathy

20. For MMP-1(-1607) 1G/2G, a significant association was observed using the recessive genetic model. In the subgroup studies, a significant association was observed in the Asian subgroup (OR = 1.68; for the recessive model; and OR = 1.59; for the allelic contrast model) and in the European subgroup (OR = 0.65; for the allelic contrast model).

Pig (Porcine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. the identification of MMP1 and MMP10 genes in swine is reported.

2. increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c pathway and may be due to enhanced phosphorylation of mmp1

3. Results indicate that leukemia inhibitory factor (LIF) and Oncostatin M increase the expression of MMP-1, MMP-3, and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF antagonist MH35-BD.

Fruit Fly (Drosophila melanogaster) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. there are only two MMP genes in Drosophila, DmMmp1 and DmMmp2, which makes Drosophila an attractive system to analyze the basis of MMP specificity. Previously, Drosophila MMPs have been categorized by their pericellular localization, as Mmp1 appeared to be secreted and Mmp2 appeared to be membrane-anchored, suggesting that protein localization was the critical distinction in this small MMP family

2. results suggest that Ubx regulates organ shape by controlling Mmp1 expression, and the extent and timing of extracellular matrix degradation.

3. This work identifies Draper-dependent activation of MMP-1 as a novel cascade required for proper glial clearance of severed axons.

4. Mmp1 negatively regulates ectopic eye differentiation by restricting the rate of proliferation and the levels of expression of retinal-determining genes dachshund and eyes absent.

5. Data indicate that matrix metalloproteinases mmp1 and mmp2 mutants have distinct heart phenotypes.

6. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

7. A primary function of Mmp1, under the control of the JNK pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.

8. Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut homeostasis

9. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development.

10. MMP activity is essential for embryonic motor axon fasciculation

11. Study identified three genes, regeneration (rgn), augmenter of liver regeneration (alr) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.

Cow (Bovine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. BoHV-4 infection affects various pathways related to cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1). MMP1 transcription was upregulated by the BoHV-4 transactivator IE2/RTA, leading to abnormally high metalloproteinase tissue levels, potentially leading to defective endometrium healing and unresolved inflammation.

2. The expression patterns of MMP1, MMP2, and MMP8 were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2, and MMP8 expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2, and MMP8 were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

3. Data suggest that luteolytic factors (such as interferon gamma, tumor necrosis factor alpha, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

4. The results showed that a decrease in MMP-1 and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

5. Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.

6. MMP-1 promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB

7. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

8. the differential expression and localization of membrane-type 1 matrix metalloproteinase in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2

9. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (follicular apex vs. base) for the preovulatory collagenolysis required for follicle rupture

10. identification of MT1-MMP in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface

11. MT1-MMP has a role in signaling events mediating EGFR transactivation

12. IL-4 and IL-13 affect airway smooth muscle (SM) gel contraction via a phosphatidylinositol 3-kinase mediated endogenous production of MMP-1 that alters the interaction between SM cells and collagen fibers.

13. In cervix, MMP1 is only active during the final cervical ripening process at parturition.

Rabbit Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. There were clear time-dependent degenerative changes in the histology of the medial meniscus after PCL rupture. The high expression of TIMP-1, MMP-1 and MMP-13 in the cartilage may be responsible for the degeneration, and PCL rupture may trigger meniscus degradation and ultimately osteoarthritis

2. These results suggest that PEP-1-SIRT2 promotes matrix metalloproteinases-induced dedifferentiation via ERK signaling in articular chondrocytes. .

3. the total content and active forms of matrix metalloproteinases (MMPs)-1, -3, and -13 was measured to assess the potential role of the mechanical environment in regulation of matrix turnover by ligament fibroblasts.

4. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 secretion.

Horse (Equine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. ANXA2 and MMP1 might participate in remodeling during wound healing in the horse.

2. The polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.

3. These results suggest that MMP-1 and IL-8 are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Xenopus laevis Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. matrix metalloproteinases 7, 9, and 18 are required in vivo for macrophage migration during embryonic development