Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) ELISA Kits

Human Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. MMP1 was consistently and significantly upregulated in the induced pluripotent stem cells-derived endothelia from autosomal dominant polycystic kidney disease patients with intracranial aneurysms compared with the patients without intracranial aneurysms in multiple assays, indicating that high serum MMP1 levels may be a novel risk factor.

2. cabozantinib suppressed MMP1 expression by blocking HGF (show HGF ELISA Kits)-MET signaling and that HGF (show HGF ELISA Kits)-MET-MMP1 signaling is involved in the invasiveness and proliferation of BCa (show BLNK ELISA Kits) cells. These results suggest that cabozantinib might prove useful for future treatment of muscle-invasive BCa (show BLNK ELISA Kits).

3. rs1144393 in the MMP1 promoter region can be a predictor of grade >/= 2 RILI in lung cancer patients treated with thoracic radiation.

4. The present results suggested that Icariin may have a chondroprotective effect, exerted through the inhibition of MMP1, MMP3 (show MMP3 ELISA Kits) and MMP13 (show MMP13 ELISA Kits) via MAPK (show MAPK1 ELISA Kits) pathways. Therefore, Icariin may have potential as a novel therapeutic strategy for the treatment of osteoarthritis.

5. proteolysis of collagen-rich natural extracellular matrix (ECM (show MMRN1 ELISA Kits)), performed uniquely by individual homologous proteases, leads to distinct events that eventually affect overall ECM (show MMRN1 ELISA Kits) morphology, viscoelastic properties, and molecular composition.

6. SAA1 (show SAA1 ELISA Kits) can be a potential mediator for UV-induced MMP-1 expression in human skin.

7. collagen II-activated phosphorylated-DDR2 (show DDR2 ELISA Kits) induces CYR61 (show CYR61 ELISA Kits) through activation of transcription factor activator protein 1 (AP-1 (show FOSB ELISA Kits)). The elevated CYR61 (show CYR61 ELISA Kits), in turn, accelerates MMP1 production via ETS1 (ETS (show ETS1 ELISA Kits) proto-oncogene (show RAB1A ELISA Kits) 1).

8. M. tuberculosis infection caused enhanced MMP-1, -9, and miR (show MLXIP ELISA Kits)-223 expression, with inhibited BMAL1 (show ARNTL ELISA Kits) expression. MiR (show MLXIP ELISA Kits)-223 modulated BMAL1 (show ARNTL ELISA Kits) expression via the direct binding of BMAL1 (show ARNTL ELISA Kits) 3'-UTR (show UTS2R ELISA Kits).

9. 20(S)-PPD (show HPD ELISA Kits) treatment modulated MMP-1 mRNA expression and the transcriptional activity of activator protein (AP)-1 (show FOSB ELISA Kits), a major transcription factor of MMP-1.

10. This is the first study to indicate that the genotypes of MMP1 promoter -1607, do not significantly confer susceptibility to lung cancer in a Taiwanese population.

Pig (Porcine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. the identification of MMP1 and MMP10 (show MMP10 ELISA Kits) genes in swine is reported.

2. increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c (show PKC ELISA Kits) pathway and may be due to enhanced phosphorylation of mmp1

3. Results indicate that leukemia inhibitory factor (LIF (show LIF ELISA Kits)) and Oncostatin M (show OSM ELISA Kits) increase the expression of MMP-1, MMP-3 (show MMP3 ELISA Kits), and TIMP-1 (show TIMP1 ELISA Kits) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF ELISA Kits) antagonist MH35-BD.

Fruit Fly (Drosophila melanogaster) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. Mmp1 negatively regulates ectopic eye differentiation by restricting the rate of proliferation and the levels of expression of retinal-determining genes dachshund and eyes absent.

2. Data indicate that matrix metalloproteinases mmp1 and mmp2 (show MMP2 ELISA Kits) mutants have distinct heart phenotypes.

3. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

4. A primary function of Mmp1, under the control of the JNK (show MAPK8 ELISA Kits) pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.

5. Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut (show GUSB ELISA Kits) homeostasis

6. Study identified three genes, regeneration (rgn (show RGN ELISA Kits)), augmenter of liver regeneration (alr (show GFER ELISA Kits)) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.

Mouse (Murine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. that MMP-13 (show MMP13 ELISA Kits) is a central protease in infarct development and cortical remodeling during post-stroke neurorepair

2. the phenotype seen in the Hdac4 (show HDAC5 ELISA Kits)(-/-) mice is partially derived from elevation in MMP-13 (show MMP13 ELISA Kits) and may be due to a bone remodeling disorder caused by overexpression of this enzyme.

3. MEF2C (show MEF2C ELISA Kits) is necessary for Mmp13 (show MMP13 ELISA Kits) gene expression at the transcriptional level and participates in PTH (show PTH ELISA Kits)-stimulated Mmp13 (show MMP13 ELISA Kits) gene expression by increased binding to c-FOS at the AP-1 (show JUN ELISA Kits) site in the Mmp13 (show MMP13 ELISA Kits) promoter.

4. data reveal a novel involvement of MMP-13 (show MMP13 ELISA Kits) in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (show CCL1 ELISA Kits) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (show CD8A ELISA Kits)(+) T-cell response in vitro; MMP-13 (show MMP13 ELISA Kits) might be a promising target for therapeutic intervention in inflammatory diseases

5. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (show DDR2 ELISA Kits)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (show DDR2 ELISA Kits) and matrix metalloproteinase 13 (show MMP13 ELISA Kits).

6. Postnatal chondrocyte-specific deletion of Hdac3 (show HDAC3 ELISA Kits) with an inducible Col2a1 (show COL2A1 ELISA Kits)-Cre caused premature production of pErk1/2 and Mmp13 (show MMP13 ELISA Kits) in the growth plate.

7. Mmp13 (show MMP13 ELISA Kits) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (show PTH ELISA Kits), and Osterix (show SP7 ELISA Kits) through distal enhancers.

8. Our study contributes to the understanding of the role of HIF1alpha (show HIF1A ELISA Kits) in OA and highlights the HIF1alpha (show HIF1A ELISA Kits)-beta-catenin (show CTNNB1 ELISA Kits) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.

9. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1/protease-activated receptor-1 (show F2R ELISA Kits) axis may play a role in neurogenesis following physiological and/or pathological stimuli.

10. IL-1Ra (show IL1RN ELISA Kits) is associated with MMP-13 (show MMP13 ELISA Kits) expression and has a novel function in such regulation without interference of the IL-1 (show IL1A ELISA Kits) signaling cascade.

Cow (Bovine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. BoHV-4 infection affects various pathways related to cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1). MMP1 transcription was upregulated by the BoHV-4 transactivator IE2/RTA (show RBM9 ELISA Kits), leading to abnormally high metalloproteinase tissue levels, potentially leading to defective endometrium healing and unresolved inflammation.

2. The expression patterns of MMP1, MMP2 (show MMP2 ELISA Kits), and MMP8 (show MMP8 ELISA Kits) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2 (show MMP2 ELISA Kits), and MMP8 (show MMP8 ELISA Kits) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2 (show MMP2 ELISA Kits), and MMP8 (show MMP8 ELISA Kits) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

3. Data suggest that luteolytic factors (such as interferon gamma (show IFNG ELISA Kits), tumor necrosis factor alpha (show TNF ELISA Kits), and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

4. The results showed that a decrease in MMP-1 and MMP-2 (show MMP2 ELISA Kits) gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

5. Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.

6. MMP-1 promotes VEGFR2 (show KDR ELISA Kits) expression and proliferation of endothelial cells through stimulation of PAR-1 (show F2R ELISA Kits) and activation of NF-kappaB (show NFKB1 ELISA Kits)

7. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

8. the differential expression and localization of membrane-type 1 matrix metalloproteinase (show MMP14 ELISA Kits) in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2 (show MMP2 ELISA Kits)

9. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (show MMP13 ELISA Kits) (follicular apex (show APEX1 ELISA Kits) vs. base) for the preovulatory collagenolysis required for follicle rupture

10. identification of MT1-MMP (show MMP14 ELISA Kits) in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface

Rabbit Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. These results suggest that PEP-1-SIRT2 (show SIRT2 ELISA Kits) promotes matrix metalloproteinases-induced dedifferentiation via ERK (show MAPK1 ELISA Kits) signaling in articular chondrocytes. .

2. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 (show TIMP3 ELISA Kits) secretion.

Horse (Equine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

1. ANXA2 (show ANXA2 ELISA Kits) and MMP1 might participate in remodeling during wound healing in the horse.

2. The polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.

3. These results suggest that MMP-1 and IL-8 (show IL8 ELISA Kits) are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Xenopus laevis Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners