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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art. Additionally we are shipping Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Kits (162) and Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Proteins (52) and many more products for this protein.
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Human Polyclonal MMP3 Primary Antibody for IF (p), IHC (p) - ABIN668301
Luo, Zhang, Wang, Hu, Song, Su, Zhang: Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats. in Bone 2013
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Human Polyclonal MMP3 Primary Antibody for WB - ABIN3043409
Tang, Huang, Qian, Xiong, Shen, Wu, Bian, Wei: Microarray analysis reveals the role of matrix metalloproteinases in mouse experimental autoimmune myocarditis induced by cardiac myosin peptides. in Cellular & molecular biology letters 2007
Show all 6 Pubmed References
Human Polyclonal MMP3 Primary Antibody for EIA, IHC (p) - ABIN265531
Muto, Kokubu, Mifune, Inui, Harada, Yoshifumi, Takase, Kuroda, Kurosaka: Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell apoptosis are associated with tendon degeneration or rupture after corticosteroid injection. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2014
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Human Monoclonal MMP3 Primary Antibody for CyTOF, FACS - ABIN4899353
Villeneuve, Block, Le Bousse-Kerdilès, Lepreux, Nurden, Ripoche, Nurden: Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins. in Experimental hematology 2009
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Human Monoclonal MMP3 Primary Antibody for FACS, ELISA - ABIN969539
Nan, Niu, Hunter, Han: Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008
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Human Polyclonal MMP3 Primary Antibody for IHC, IHC (p) - ABIN4335045
Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011
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Human Polyclonal MMP3 Primary Antibody for IHC (p), IHC - ABIN407748
Wu, Lee, Ido, Fried: High-fat diet-induced obesity regulates MMP3 to modulate depot- and sex-dependent adipose expansion in C57BL/6J mice. in American journal of physiology. Endocrinology and metabolism 2016
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Cow (Bovine) Polyclonal MMP3 Primary Antibody for IHC, WB - ABIN2777122
Stickel, Osterreicher, Halangk, Berg, Homann, Hellerbrand, Patsenker, Schneider, Kolb, Friess, Schuppan, Puhl, Seitz, Leathart, Day: No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease. in Alcoholism, clinical and experimental research 2008
Mouse (Murine) Polyclonal MMP3 Primary Antibody for IHC, WB - ABIN3021709
Xia, Zhang, Ge: C/EBPβ Mediates TNF-α-Induced Cancer Cell Migration by Inducing MMP Expression Dependent on p38 MAPK. in Journal of cellular biochemistry 2015
Horse (Equine) Polyclonal MMP3 Primary Antibody for WB - ABIN223232
De Vries, Dover, Casey, Vandehaar, Plaut: Characterization of mammary stromal remodeling during the dry period. in Journal of dairy science 2010
MMP3 contributes to the pathogenesis of ARDS by affecting the pulmonary inflammatory response in female mice in relevant models of lung injury.
endogenously secreted chemerin (show RARRES2 Antibodies) plays an autocrine/paracrine role in white adipose tissue, identifying chemerin (show RARRES2 Antibodies) as a therapeutic target to modulate adipose remodelling.
Overexpression of Mmp3 in 3T3-L1 preadipocytes inhibited differentiation. High fat diet-induced obesity downregulates adipocyte MMP3 expression to trigger adipogenesis, and adipocyte TIMP4 (show TIMP4 Antibodies) may modulate this process to regulate hyperplastic vs. hypertrophic adipose tissue expansion, fat distribution, and metabolic health in a sex- and depot-dependent manner.
Matrix metalloprotease (show ADAMTS7 Antibodies) 3 (MMP3), an endogenous neuronal activator of microglia, increased cytokine release from YAC128 microglia compared to wildtype microglia. We found elevated MMP levels in Huntington's Disease (HD) CSF (show CSF2 Antibodies), and MMP levels correlate with disease severity in HD. These data support a novel role for MMPs and microglial activation in HD pathogenesis.
These results indicate that periodic induction, via use of an eye drop, of AAV-mediated secretion of MMP-3 into aqueous humour could have therapeutic potential for those cases of glaucoma that are sub-optimally responsive to conventional pressure-reducing medications.
Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 (show CPT1B Antibodies) and (C-X-C motif) ligand 1 (CXCL1 (show CXCL1 Antibodies)).
Mmp3-knockout mice maintained higher arterial oxygenation compared to wild-type mice in a model of acute lung injury.
NMP4 (show ZNF384 Antibodies) deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL (show TNFSF11 Antibodies) and MMP-3 mRNA.
MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK (show MAPK14 Antibodies) activation and proNGF production
genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice
MMP-3 (Lys45Glu) polymorphisms associate with obesity risk and its severity.
Data suggest that serum matrix metalloproteinase-3 (MMP-3) and the 7-joint ultrasound score (US7) scores could both effectively reflect disease activity and therapeutic responses in patients with moderate to severe rheumatoid arthritis (RA).
results demonstrated that measurement of MMP-3 could become a marker of disease activity in rheumatoid arthritis patients
The results indicated that the 5A allele of the MMP3 gene-promoter region could be associated with oral submucous fibrosis risk factor, but not oral squamous cell carcinoma, in an Indian population
C/EBPbeta (show CEBPB Antibodies) upregulation promoted tumor cell invasion in an MMP3-dependent manner in vitro and was associated with metastatic status in colorectal cancer
MMP3 (and MMP-1 (show MMP1 Antibodies) and MMP-2 (show MMP2 Antibodies)) are independently associated with markers of arterial stiffening in patients with type 1 diabetes.
A significant increase in the frequency of the MMP3-1171dupA (rs3025058) polymorphism genotype among patients with unstable angina was detected.
No interaction between MMP-3 5A/6A polymorphism and the risk of recurrence in total IS patients was found. The variant 5A/6A+5A/5A genotype and the 5A allele were significantly associated with a high risk of recurrence for large-artery atherosclerosis (LAA) (multivariate-adjusted, P=0.002, 0.001, respectively), but not for small-artery occlusion and cardioembolism.
The 5A allele of the MMP3-gene promoter polymorphism is a potential risk factor in the poor outcome of hemodialysis patients.
Positive MMP-3 was not significantly related to osteoporosis or severe hand osteoarthritis.
The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1 (show TGFB1 Antibodies)) and collagen type X alpha I (COL10A1 (show COL10A1 Antibodies)) gene polymorphisms with traits related to leg weakness in pigs.
the identification of MMP1 (show MMP1 Antibodies) and MMP10 (show MMP10 Antibodies) genes in swine is reported.
contribution of MMPs to the inflammatory breakdown of the blood-CSF (show CSF2 Antibodies) barrier in vitro
Results indicate that leukemia inhibitory factor (LIF (show LIF Antibodies)) and Oncostatin M (show OSM Antibodies) increase the expression of MMP-1 (show MMP1 Antibodies), MMP-3, and TIMP-1 (show TIMP1 Antibodies) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Antibodies) antagonist MH35-BD.
Compromised autophagy may be related to the osteoarthritis progression; JNK (show MAPK8 Antibodies) and p38 (show MAPK14 Antibodies) MAPKs up-regulate MMP3 and down-regulate autophagy.
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
Ulinastatin (show AMBP Antibodies) effectively inhibited the increased expression of MMP-2 (show MMP2 Antibodies), MMP-3, and iNOS (show NOS2 Antibodies) in degenerated NP cells induced by IL-1beta (show IL1B Antibodies) in vitro.
Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma (show PPARG Antibodies) in atherosclerotic rabbits.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
, matrix metalloproteinase 3
, matrix metalloproteinase-3
, stromelysin 1
, PTR1 protein
, matrix metalloproteinase 3 (stromelysin 1, progelatinase)
, metalloproteinase 3 receptor
, matrix metallopeptidase 3 (stromelysin 1, progelatinase)
, matrix metalloproteinase 10 (stromelysin 2)