anti-Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) Antibodies

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Kits (162) and Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Proteins (54) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MMP3 4314 P08254
MMP3 17392 P28862
MMP3 171045  
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Top anti-Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Antibodies at antibodies-online.com

Showing 10 out of 369 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Anti- MMP3 Picoband antibody, Western blotting All lanes: Anti MMP3  at 0.5ug/ml Lane 1: Human Placenta Tissue Lysate at 50ug Lane 2: U20S Whole Cell Lysate at 40ug Lane 3: HELA Whole Cell Lysate at 40ug Lane 4: PANC Whole Cell Lysate at 40ug Lane 5: COLO320 Whole Cell Lysate at 40ug Predicted bind size: 54KD Observed bind size: 54KD Anti- MMP3 Picoband antibody, Western blotting All lanes: Anti MMP3  at 0.5ug/ml WB: Recombinant Human MMP3 Protein 0.5ng Predicted bind size: 36KD Observed bind size: 36KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$434.50
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-MMP3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate Sample Type: 1. Normal HUman Cartilage (50ug)2. Human Osteoarthritis cartilage (50ug)3. Human Osteoarthritis chondrocytes (50ug)4. Human Osteoarthritis chondrocytes +IL-1 (50ug)Primary Dilution: 1:2000Secondary Antibody: HRP conjugated anti-rabbitSecondary Dilution: 1:5000Image Submitted By: Mukundan AtturNYU Hospital for Joint Disease 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-MMP3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB Antibody (0.3µg/ml) staining of Mouse Eye lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Horse Rabbit Un-conjugated WB Western blot analysis of MMP-3 expression with Jurkat cell lysate. Both full length (55 kDa)  and cleaved form (21 kDa) can be detected. 100 μg Log in to see 2 to 3 Days
$255.00
Details
Human Mouse Un-conjugated CyTOF, FACS, ICC, IHC, WB Detection of MMP-3 in MG-63 Human Cell Line by Flow Cytometry. MG-63 human osteosarcoma cell line was stained with Mouse Anti-Human MMP-3 Monoclonal Antibody. Detection of Human MMP-3 by Western Blot. Western blot shows Recombinant Human MMP-3 Westrern Blot Standard Protein (2 uL 500 μg Log in to see 8 to 9 Days
$323.18
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastric mucosa labeled with Anti-MMP-3 Polyclonal Antibody (ABIN668301), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Lane 1: mouse spleen lysates Lane 2: mouse liver lysates probed with Anti MMP-3 Polyclonal Antibody, Unconjugated (ABIN668301) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 42kD,52kDkD. Observed band size: 52kD. 100 μL Log in to see 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of MMP3 staining in A431 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of MMP3 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IP, WB Western blot analysis of MMP3 expression in A549 (A), MCF7 (B), rat heart (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details

Top referenced anti-Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Antibodies

  1. Human Polyclonal MMP3 Primary Antibody for WB - ABIN3043409 : Tang, Huang, Qian, Xiong, Shen, Wu, Bian, Wei: Microarray analysis reveals the role of matrix metalloproteinases in mouse experimental autoimmune myocarditis induced by cardiac myosin peptides. in Cellular & molecular biology letters 2007 (PubMed)
    Show all 10 Pubmed References

  2. Human Polyclonal MMP3 Primary Antibody for EIA, IHC (p) - ABIN265531 : Muto, Kokubu, Mifune, Inui, Harada, Yoshifumi, Takase, Kuroda, Kurosaka: Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell apoptosis are associated with tendon degeneration or rupture after corticosteroid injection. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2014 (PubMed)
    Show all 9 Pubmed References

  3. Human Polyclonal MMP3 Primary Antibody for IF (p), IHC (p) - ABIN668301 : Luo, Zhang, Wang, Hu, Song, Su, Zhang: Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats. in Bone 2013 (PubMed)
    Show all 7 Pubmed References

  4. Human Polyclonal MMP3 Primary Antibody for IHC (p), ELISA - ABIN545719 : Mercapide, Lopez De Cicco, Castresana, Klein-Szanto: Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. in International journal of cancer. Journal international du cancer 2003 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal MMP3 Primary Antibody for IHC, IHC (p) - ABIN4335045 : Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal MMP3 Primary Antibody for CyTOF, FACS - ABIN4899353 : Villeneuve, Block, Le Bousse-Kerdilès, Lepreux, Nurden, Ripoche, Nurden: Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins. in Experimental hematology 2009 (PubMed)
    Show all 3 Pubmed References

  7. Human Polyclonal MMP3 Primary Antibody for IHC (p), IHC - ABIN407748 : Wu, Lee, Ido, Fried: High-fat diet-induced obesity regulates MMP3 to modulate depot- and sex-dependent adipose expansion in C57BL/6J mice. in American journal of physiology. Endocrinology and metabolism 2016 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal MMP3 Primary Antibody for FACS, ELISA - ABIN969539 : Nan, Niu, Hunter, Han: Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008 (PubMed)
    Show all 2 Pubmed References

  9. Cow (Bovine) Polyclonal MMP3 Primary Antibody for IHC, WB - ABIN2777122 : Stickel, Osterreicher, Halangk, Berg, Homann, Hellerbrand, Patsenker, Schneider, Kolb, Friess, Schuppan, Puhl, Seitz, Leathart, Day: No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease. in Alcoholism, clinical and experimental research 2008 (PubMed)

  10. Horse (Equine) Polyclonal MMP3 Primary Antibody for WB - ABIN223232 : De Vries, Dover, Casey, Vandehaar, Plaut: Characterization of mammary stromal remodeling during the dry period. in Journal of dairy science 2010 (PubMed)

More Antibodies against Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Interaction Partners

Human Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. The levels of MMP-3 in serum and gingival crevicular fluid of patients with rheumatoid arthritis (RA) and chronic periodontitis (CP) were significantly increased. MMP-3 may be associated with the development of CP and RA.

  2. MMP-3 (-1171) 5A/6A and Lys45Glu (A/G) polymorphisms resulting in upregulation of MMP-3 in serum were associated with the decline of lung function among chronic obstructive pulmonary disease.

  3. MMP3 was higher in rheumatoid factor negative rheumatoid arthritis than in rheumatoid factor positive rheumatoid arthritis, undifferentiated arthritis, and controls.

  4. Our results indicated that the levels of MMP-3 in gastric mucosa were not different between H. pyloripositive and H. pylori-negative patients and there was no correlation between the MMP-3 levels and virulence factor (cagA and vacA allelic variants), and type of disease (gastritis and PUD) in patients infected with H. pylori.

  5. This experiments showed that MMP3 is dynamically regulated by seizures as shown by increased expression in TLE tissue and during different phases of epileptogenesis.

  6. IL-1beta C/T and MMP3 5A/6A polymorphisms are associated with an increased risk of developing hepatocellular carcinoma in Egyptian patients.

  7. High circulating MMP3 levels were independently associated with sarcopenia in rheumatoid arthritis patients.

  8. The prevalence of knee chondrocalcinosis was low in the Japanese population and was positively correlated with serum MMP-3 concentration.

  9. Matrix Metalloproteinase-3 (MMP3) is a direct target of miR-519d.

  10. Heterogeneity Index was a significant factor associated positively with MMP-3

  11. this is the first study to demonstrate the crucial role of reactive oxygen species in the switching expression of MMP-3 in stromal fibroblasts and prostate cancer cells during tumor progression, clarifying how the tumor microenvironment modulates ECM homeostasis control.

  12. Here the authors describe the identification of gamma-activated site (GAS)-like, signal transducer and activator of transcription (STAT) binding elements (SBEs) within the proximal promoters of the MMP-1 and MMP-3 genes, which bind STAT-1 in a homodimer like complex (HDLC). They further demonstrate that MMP expression and binding of this complex to SBEs can be enhanced by interleukin (IL)-6.

  13. Our findings suggest that the ratios of the serum MMP-3 levels at baseline to those at 12 weeks could be used to predict remission in RA patients who are administered iguratimod as an add-on to bDMARDs.

  14. MMP3 (rs591058) gene polymorphism is associated with lumbar disc degeneration among women, and the TT genotype confers a lower risk of LDD.

  15. BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3.

  16. No significant associations were observed with either MMP-2(-1306) C/T or MMP-3(-1171) 5A/6A.

  17. rs3025058 in MMP3 and rs2276109 in MMP12 might not contribute to the risk of developing rheumatic heart disease in a Han population in Southern China.

  18. study to explore the relationship between 2 polymorphisms (MMP-1-755 T/G [rs498186] and MMP-3 A/C [rs632478]) and disc degeneration; a significant association was found between the MMP-3 polymorphism and disc degeneration; the homozygote CC was associated with an increased risk of disc degeneration compared with the AA genotype

  19. Higher serum MMP-3 levels in knee osteoarthritis reflect disease "generalization".

  20. Report a positive correlation between glomerular filtration rate and MMP-3 activity in diabetic patients.

Mouse (Murine) Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. that the impact of MMP3 on neuronal morphology may be regionspecific

  2. BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3.

  3. Estrogen-related receptor gamma (ERRgamma) overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 and MMP13, which are known to play crucial roles in cartilage destruction in osteoarthritis (OA).

  4. MMP3 contributes to the pathogenesis of ARDS by affecting the pulmonary inflammatory response in female mice in relevant models of lung injury.

  5. endogenously secreted chemerin plays an autocrine/paracrine role in white adipose tissue, identifying chemerin as a therapeutic target to modulate adipose remodelling.

  6. Overexpression of Mmp3 in 3T3-L1 preadipocytes inhibited differentiation. High fat diet-induced obesity downregulates adipocyte MMP3 expression to trigger adipogenesis, and adipocyte TIMP4 may modulate this process to regulate hyperplastic vs. hypertrophic adipose tissue expansion, fat distribution, and metabolic health in a sex- and depot-dependent manner.

  7. Matrix metalloprotease 3 (MMP3), an endogenous neuronal activator of microglia, increased cytokine release from YAC128 microglia compared to wildtype microglia. We found elevated MMP levels in Huntington's Disease (HD) CSF, and MMP levels correlate with disease severity in HD. These data support a novel role for MMPs and microglial activation in HD pathogenesis.

  8. These results indicate that periodic induction, via use of an eye drop, of AAV-mediated secretion of MMP-3 into aqueous humour could have therapeutic potential for those cases of glaucoma that are sub-optimally responsive to conventional pressure-reducing medications.

  9. Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 and (C-X-C motif) ligand 1 (CXCL1).

  10. Mmp3-knockout mice maintained higher arterial oxygenation compared to wild-type mice in a model of acute lung injury.

  11. NMP4 deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL and MMP-3 mRNA.

  12. MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK activation and proNGF production

  13. genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice

  14. study found significant increases of MMP-3 and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection

  15. This study demonstrates the sequential involvement of Wnt5, MMP-3, DMP-1 expression, and DMP-1 degradation products by MMP-3, in effecting IL-1beta-induced proliferation of ESC-derived odontoblast-like cells.

  16. Study suggests that MMP-3 modulates intracellular MAP kinase signaling pathway and as such, influences a molecular chaperone that regulates cytoskeletal components important for neurite outgrowth, neuronal migration and dendritic arborization

  17. Data indicate that interferon regulatory factor-8 (IRF8) regulates tumor behavior in an matrix metalloproteinase 3 (MMP3)-dependent manner.

  18. Established are novel molecular mechanisms underlying oxidative stress-mediated dopaminergic neuronal death in which MMP3 activation is a key upstream event that leads to Nox1 induction and eventual dopaminergic neuronal death.

  19. Our findings suggest that increased numbers of CD11c(+) macrophages and elevated levels of TNF-alpha and MMP-3 in AT and ST may explain the relationship between hyperlipidaemia and OA.

  20. These results demonstrated the role of MMP-3 in blood-spinal cord disruption after spinal cord injury for the first time

Pig (Porcine) Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1) and collagen type X alpha I (COL10A1) gene polymorphisms with traits related to leg weakness in pigs.

  2. the identification of MMP1 and MMP10 genes in swine is reported.

  3. contribution of MMPs to the inflammatory breakdown of the blood-CSF barrier in vitro

  4. Results indicate that leukemia inhibitory factor (LIF) and Oncostatin M increase the expression of MMP-1, MMP-3, and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF antagonist MH35-BD.

Rabbit Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. Compromised autophagy may be related to the osteoarthritis progression; JNK and p38 MAPKs up-regulate MMP3 and down-regulate autophagy.

  2. the total content and active forms of matrix metalloproteinases (MMPs)-1, -3, and -13 was measured to assess the potential role of the mechanical environment in regulation of matrix turnover by ligament fibroblasts.

  3. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

  4. Ulinastatin effectively inhibited the increased expression of MMP-2, MMP-3, and iNOS in degenerated NP cells induced by IL-1beta in vitro.

  5. Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some matrix metalloprpteases.

  6. Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.

Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) Antigen Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP3

  • matrix metallopeptidase 3 (MMP3) antibody
  • matrix metallopeptidase 3 (Mmp3) antibody
  • matrix metallopeptidase 3 (stromelysin 1, progelatinase) (MMP3) antibody
  • matrix metallopeptidase 3 L homeolog (mmp3.L) antibody
  • chds6 antibody
  • mmp-3 antibody
  • mmp3 antibody
  • MMP10 antibody
  • mmp13 antibody
  • sl-1 antibody
  • SLN-1 antibody
  • SLN1 antibody
  • stmy antibody
  • stmy1 antibody
  • STR-1 antibody
  • str1 antibody

Protein level used designations for MMP3

matrix metalloproteinase 3 (stromelysin 1, progelatinase) , matrix metalloproteinase-3 , proteoglycanase , stromelysin-1 , transin-1 , EMS-2 , MMP-3 , SL-1 , matrix metalloproteinase 3 , progelatinase , stromelysin 1 , PTR1 protein , stromelysin , metalloproteinase 3 receptor , matrix metallopeptidase 3 (stromelysin 1, progelatinase) , matrix metallopeptidase 3 L homeolog , matrix metalloproteinase 13 (collagenase 3)

GENE ID SPECIES
4314 Homo sapiens
17392 Mus musculus
171045 Rattus norvegicus
396769 Sus scrofa
100009111 Oryctolagus cuniculus
100034195 Equus caballus
403445 Canis lupus familiaris
281309 Bos taurus
101118895 Ovis aries
446898 Xenopus laevis
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