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The protein encoded by MIA2 is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. Additionally we are shipping MIA2 Antibodies (88) and MIA2 Kits (12) and many more products for this protein.
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TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats.
In this study, we identified specific and critical residues in the Sec12 (show PREB Proteins)-binding region of cTAGE5 (E75A K76A, K89A, and S97A) and confirmed that cTAGE5-mediated Sec12 (show PREB Proteins) accumulation at ER exit sites is required for collagen VII (show TH Proteins) secretion.
Data indicate that MIA2 represents a potential novel acute phase protein (show ORM1 Proteins) and MIA2 expression responds to liver damage in chronic liver diseases.
The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma.
population and bioinformatic analysis of MGEA6 P521A variation as a risk factor for Fahr's disease; genetic screen data show this mutation is very rare; bioinformatics analysis provided conflicting findings
cTAGE5 forms a complex with TANGO1 (MIA3 (show MIA3 Proteins)), a previously characterized cargo receptor for collagen VII (show TH Proteins)
HBx activates hepatoma cell growth and proliferation through repression of the potential tumor suppressor MIA2.
22 members of an Iranian family with basal ganglia calfication as well as 100 controls were genotyped for the C>G P521A variant of CTAGE5, but none were found.
Findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase (show MAPK1 Proteins) in oral carcinoma.
Sec12 (show PREB Proteins) recruitment to endoplasmic reticulum exit sites is organized by its direct interaction with cTAGE5, a previously characterized collagen cargo receptor component, which functions together with TANGO1 (show MIA3 Proteins) at endoplasmic reticulum exit sites.
Conditional knockout of cTAGE5/MEA6 in the brain leads to severe defects in neural development, including deficits in dendrite outgrowth and branching, spine formation and maintenance, astrocyte activation, and abnormal behaviors
cTAGE5 deletion in pancreatic beta cells impairs proinsulin (show INS Proteins) trafficking and insulin (show INS Proteins) biogenesis in mice.
Mia2 is a novel, hepatic, endoplasmic reticulum-to-Golgi trafficking protein that regulates cholesterol metabolism.
The protein encoded by this gene is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. Autoantibodies against the encoded protein have been found in some cancers. Several transcript variants encoding different isoforms have been found for this gene.
cTAGE family member 5
, cutaneous T-cell lymphoma-associated antigen 5
, meningioma expressed antigen 6 (coiled-coil proline-rich)
, meningioma-expressed antigen 6/11
, protein cTAGE-5
, melanoma inhibitory activity protein 2