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The protein encoded by MS4A12 is a cell surface protein found primarily in the apical membrane of colonocytes.
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RNA interference of CDX1 (show CDX1 Antibodies) and CDX2 (show CDX2 Antibodies) and chromatin immunoprecipitation in colon cancer cells revealed that MS4A12 transcript and protein expression is essentially dependent on the presence of endogenous CDX2 (show CDX2 Antibodies).
MS4A12 is a colon-selective store-operated calcium channel (show TRPC1 Antibodies) promoting malignant cell processes.
The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene.
membrane-spanning 4-domains subfamily A member 12
, membrane-spanning 4-domains, subfamily A, member 12