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The protein encoded by MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Additionally we are shipping MANF Kits (41) and MANF Proteins (31) and many more products for this protein.
Showing 10 out of 107 products:
Human Polyclonal MANF Primary Antibody for IHC, ELISA - ABIN1002798
Petrova, Raibekas, Pevsner, Vigo, Anafi, Moore, Peaire, Shridhar, Smith, Kelly, Durocher, Commissiong: MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. in Journal of molecular neuroscience : MN 2003
Show all 4 Pubmed References
Human Polyclonal MANF Primary Antibody for IHC, ELISA - ABIN1002799
Shridhar, Rivard, Shridhar, Mullins, Bostick, Sakr, Grignon, Miller, Smith: A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. in Oncogene 1996
Show all 4 Pubmed References
Human Polyclonal MANF Primary Antibody for ELISA, WB - ABIN451593
Shridhar, Shridhar, Rivard, Siegfried, Pietraszkiewicz, Ensley, Pauley, Grignon, Sakr, Miller, Smith: Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. in Cancer research 1997
Human Polyclonal MANF Primary Antibody for IHC, IHC (p) - ABIN4281647
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Our data indicate that increased MANF concentrations in serum are associated with the clinical manifestation of type 1 diabetes in children, but the exact mechanism behind the increase remains elusive
Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death.
Serum MANF level was higher in patients with newly diagnosed prediabetes and T2 Diabetes Mellitus than in normal glucose tolerance controls. MANF appears to be associated with Matsuda Index, QUICKI and HOMA-IR in prediabetes patients.
the role of two short sequence motifs within the carboxy-(C) terminal domain of MANF in its neuroprotective activity, was studied.
the selective expression of MANF in splenocytes may be involved in plasma cell differentiation and immune regulation.
MANF is a protein that interacts with RTN1-C (show RTN1 Antibodies)
We demonstrate that Armet and Creld2 (show CRELD2 Antibodies) are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 (show MATN3 Antibodies) is a key disease trigger in MED that could be exploited as a potential therapeutic target
MANF binding to the plasma membrane also required the RTDL sequence and was inhibited with a peptide known to interact with KDELRs, suggesting MANF binds KDELRs at the surface.
MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
Pretreatment with adeno (show ADORA2A Antibodies)-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats.
Study shows that MANF is not only expressed in postmitotic neurons but also in mitotic neural stem cells (NSCs) in the mammalian brain, andthat MANF does not affect self-renewal capacity or proliferation of NSCs and suggest that MANF is dispensable for neurogenesis. MANF plays a significant role in neurite growth in the process of neuronal differentiation, which is likely the cause for delayed neuronal migration.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic factor (show NTF3 Antibodies) that is secreted but also mediates the unfolded protein response acting intracellularly.
MANF decreased the proinflammatory cytokines of IL-1beta (show IL1B Antibodies), TNF-alpha (show TNF Antibodies), and IFN-gamma induced (show SAMHD1 Antibodies) by LPS (show TLR4 Antibodies) by regulating NF-kappaB (show NFKB1 Antibodies) and phosphorylation of p38 (show CRK Antibodies)-mitogen-activated protein kinases (MAPKs) pathways
MANF has immune modulatory properties that are required for retinal repair in Drosophila
secretion of mouse MANF and mouse CDNF (show CDNF Antibodies) is fundamentally regulated in the same manner, the variation of four C-terminal amino acids in the MANF and CDNF (show CDNF Antibodies) among species might influence their intracellular functions.
MANF-deficient mice develop severe diabetes, progressive postnatal reduction of beta cell mass and chronic unfolded protein response activation.
Secretion of MANF is regulated via COPII-mediated transport and that its C-terminus could be responsible for its retention in the endoplasmic reticulum through GRP78 (show HSPA5 Antibodies).
The change in Armet expression lasted while the change of Mrpl51 (show MRPL51 Antibodies) disappeared after birth.
the solution structure of ARMET
ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the endoplasmic reticulum
Study employed the Drosophila genetics to screen for potential interaction partners of Drosophila Manf (DmManf) in vivo; show that DmManf plays a role in the development of Drosophila wing.
These data suggest a role for Manf in the regulation of Drosophila unfolded protein response.
DmMANF expression in the adult brain is much wider than in the embryonic and larval stages. It is expressed in both glia and neurons including dopaminergic neurons.
study offers further insights into the functional conservation between invertebrate and mammalian MANF/CDNF (show CDNF Antibodies) proteins and reveals the importance of the C-terminal domain for MANF activity in vivo
role of MANF in multicellular organism development
DmMANF is an invertebrate neurotrophic factor (show NTF3 Antibodies) supporting dopaminergic neurons.
These results suggest that MANF is involved in the regulation of the development of dopaminergic system in zebrafish.
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors\; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
arginine-rich, mutated in early stage tumors
, arginine-rich protein
, mesencephalic astrocyte-derived neurotrophic factor
, RNA binding motif protein 15B
, chromosome 3p21.1 gene sequence
, LOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor
, mesencephalic astrocyte-derived neurotrophic factor S homeolog