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Involved in the formation and segmentation of paraxial mesoderm.
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Transgenic analysis of the Mespo promoter identifies Mespo as a direct downstream target of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
Xtbx6 (show TBX6 Antibodies) is a direct regulator of pMesogenin1 and 2, which are both involved in somitogenesis and myogenesis including that of body wall muscle in Xenopus laevis
Described the cloning, expression and function of the mouse and frog mesogenin 1.
Msgn1 functions downstream of Wnt3a (show WNT3A Antibodies) as the master regulator of paraxial presomitic mesoderm differentiation.
Msgn1 exerts at least two functions in the mesoderm where it promotes differentiation into paraxial mesoderm, and is likely a key player in regulating cell migration.
The Wnt3a (show WNT3A Antibodies)/beta-catenin (show CTNNB1 Antibodies) target gene Mesogenin1 controls the segmentation clock by activating a Notch (show NOTCH1 Antibodies) signalling program.
The expression of mesogenin 1, a basic helix-loop-helix transcription factor (show HEY1 Antibodies), which is essential for psm (show SH2B1 Antibodies) maturation, is regulated by synergism between WNT (show WNT2 Antibodies) signalling and the T-box 6 (show TBX6 Antibodies) transcription factor, involving a feed-forward control mechanism.
Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors.(
Through its combined effects on gene expression and cell movement, Msgn1 (with Spt (show AGXT Antibodies)) plays a key role both in genesis of the paraxial mesoderm and in maintenance of the progenitor population from which it derives.
Msgn1 expression in association with that of ntl may allow the differentiation of progenitor cells to proceed during development of somites in the tail.
mespo expression is intensified in the involuting mesoderm at 60% epiboly, and then restricted to the presomitic mesoderm (PSM (show SH2B1 Antibodies)) at 95% epiboly. At the 1-somite stage, mespo expression becomes reduced in the most rostral PSM (show SH2B1 Antibodies).
Involved in the formation and segmentation of paraxial mesoderm. Has the regulatory capacity to specify ventrolateral (including future paraxial), but not dorsal (future axial), mesoderm phenotypes. Seems to be an upstream regulator of at least some elements of the Notch and Delta signaling pathway (By similarity).
, MesP-related bHLH factor
, mesogenin, Mespo MesP-related bHLH factor
, bHLH transcription factor pMesogenin2
, paraxial mesoderm-specific mesogenin1
, paraxial mesogenin
, paraxial mesoderm-specific expression and regulatory capacities
, bHLH transcription factor
, protein cMespo
, mesP-related bHLH factor